PMID:
     3539918
Authors:
     VanBogelen RA, Kelley PM, Neidhardt FC.
Title:
     Differential induction of heat shock, SOS, and oxidation stress regulons and 
     accumulation of nucleotides in Escherichia coli.
Journal:
     J Bacteriol. 1987 Jan;169(1):26-32. doi: 10.1128/jb.169.1.26-32.1987.
Abstract:
     Heat and various inhibitory chemicals were tested in Escherichia coli for the 
     ability to cause accumulation of adenylylated nucleotides and to induce proteins 
     of the heat shock (htpR-controlled), the oxidation stress (oxyR-controlled), and 
     the SOS (lexA-controlled) regulons. Under the conditions used, heat and ethanol 
     initiated solely a heat shock response, hydrogen peroxide and 
     6-amino-7-chloro-5,8-dioxoquinoline (ACDQ) induced primarily an oxidation stress 
     response and secondarily an SOS response, nalidixic acid and puromycin induced 
     primarily an SOS and secondarily a heat shock response, isoleucine restriction 
     induced a poor heat shock response, and CdCl2 strongly induced all three stress 
     responses. ACDQ, CdCl2, and H2O2 each stimulated the synthesis of approximately 
     35 proteins by factors of 5- to 50-fold, and the heat shock, oxidation stress, 
     and SOS regulons constituted a minor fraction of the overall cellular response. 
     The pattern of accumulation of adenylylated nucleotides during these treatments 
     was inconsistent with a simple role for these nucleotides as alarmones sufficient 
     for triggering the heat shock response, but was consistent with a role in the 
     oxyR-mediated response.

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