PMID:
7498158
Authors:
Gravel P, Sanchez JC, Walzer C, Golaz O, Hochstrasser DF, Balant LP,
Hughes GJ, Garcia-Sevilla J, Guimon J.
Title:
Human blood platelet protein map established by two-dimensional polyacrylamide
gel electrophoresis.
Journal:
Electrophoresis. 1995 Jul;16(7):1152-9. doi: 10.1002/elps.11501601191.
Abstract:
Two-dimensional (2-D) maps of cytosol and enriched-membrane platelet proteins has
allowed the identification of more than 25 spots by three different methods:
matching of the platelet gels with other 2-D reference maps, immunoblotting with
chemiluminescence detection, and N-terminal sequencing. Different G protein
(guanosine triphosphate-binding protein) subunits, cytoskeletal proteins, and
proteins common to the human liver, red blood cells and plasma were identified.
The two platelet protein maps presented here contribute to the project of
identification of human cell and body fluid proteins. They may serve as working
tools since platelets are popular models for the study of central nervous system
neurotransmitter systems and stimulus-response coupling mechanisms.
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