PMID:
     8407824
Authors:
     Sanchez Y, Parsell DA, Taulien J, Vogel JL, Craig EA, Lindquist S.
Title:
     Genetic evidence for a functional relationship between Hsp104 and Hsp70.
Journal:
     J Bacteriol. 1993 Oct;175(20):6484-91. doi: 10.1128/jb.175.20.6484-6491.1993.
Abstract:
     The phenotypes of single Hsp104 and Hsp70 mutants of the budding yeast 
     Saccharomyces cerevisiae provide no clue that these proteins are functionally 
     related. Mutation of the HSP104 gene severely reduces the ability of cells to 
     survive short exposures to extreme temperatures (thermotolerance) but has no 
     effect on growth rates. On the other hand, mutations in the genes that encode 
     Hsp70 proteins have significant effects on growth rates but do not reduce 
     thermotolerance. The absence of a thermotolerance defect in S. cerevisiae Hsp70 
     mutants is puzzling, since the protein clearly plays an important role in 
     thermotolerance in a variety of other organisms. In this report, examination of 
     the phenotypes of combined Hsp104 and Hsp70 mutants uncovers similarities in the 
     functions of Hsp104 and Hsp70 not previously apparent. In the absence of the 
     Hsp104 protein, Hsp70 is very important for thermotolerance in S. cerevisiae, 
     particularly at very early times after a temperature upshift. Similarly, Hsp104 
     plays a substantial role in vegetative growth under conditions of decreased Hsp70 
     protein levels. These results suggest a close functional relationship between 
     Hsp104 and Hsp70.

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