KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108526885
Entry
108526885         CDS       T04641                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb00562  Inositol phosphate metabolism
rbb01100  Metabolic pathways
rbb04015  Rap1 signaling pathway
rbb04020  Calcium signaling pathway
rbb04022  cGMP-PKG signaling pathway
rbb04062  Chemokine signaling pathway
rbb04070  Phosphatidylinositol signaling system
rbb04071  Sphingolipid signaling pathway
rbb04072  Phospholipase D signaling pathway
rbb04261  Adrenergic signaling in cardiomyocytes
rbb04270  Vascular smooth muscle contraction
rbb04310  Wnt signaling pathway
rbb04371  Apelin signaling pathway
rbb04540  Gap junction
rbb04611  Platelet activation
rbb04613  Neutrophil extracellular trap formation
rbb04621  NOD-like receptor signaling pathway
rbb04713  Circadian entrainment
rbb04720  Long-term potentiation
rbb04723  Retrograde endocannabinoid signaling
rbb04724  Glutamatergic synapse
rbb04725  Cholinergic synapse
rbb04726  Serotonergic synapse
rbb04728  Dopaminergic synapse
rbb04730  Long-term depression
rbb04742  Taste transduction
rbb04750  Inflammatory mediator regulation of TRP channels
rbb04911  Insulin secretion
rbb04912  GnRH signaling pathway
rbb04915  Estrogen signaling pathway
rbb04916  Melanogenesis
rbb04918  Thyroid hormone synthesis
rbb04919  Thyroid hormone signaling pathway
rbb04921  Oxytocin signaling pathway
rbb04922  Glucagon signaling pathway
rbb04924  Renin secretion
rbb04925  Aldosterone synthesis and secretion
rbb04926  Relaxin signaling pathway
rbb04927  Cortisol synthesis and secretion
rbb04928  Parathyroid hormone synthesis, secretion and action
rbb04929  GnRH secretion
rbb04933  AGE-RAGE signaling pathway in diabetic complications
rbb04934  Cushing syndrome
rbb04935  Growth hormone synthesis, secretion and action
rbb04961  Endocrine and other factor-regulated calcium reabsorption
rbb04970  Salivary secretion
rbb04971  Gastric acid secretion
rbb04972  Pancreatic secretion
rbb04973  Carbohydrate digestion and absorption
rbb05010  Alzheimer disease
rbb05016  Huntington disease
rbb05017  Spinocerebellar ataxia
rbb05022  Pathways of neurodegeneration - multiple diseases
rbb05142  Chagas disease
rbb05143  African trypanosomiasis
rbb05146  Amoebiasis
rbb05163  Human cytomegalovirus infection
rbb05200  Pathways in cancer
rbb05415  Diabetic cardiomyopathy
rbb05417  Lipid and atherosclerosis
Module
rbb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108526885 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    108526885 (PLCB2)
   04310 Wnt signaling pathway
    108526885 (PLCB2)
   04371 Apelin signaling pathway
    108526885 (PLCB2)
   04020 Calcium signaling pathway
    108526885 (PLCB2)
   04070 Phosphatidylinositol signaling system
    108526885 (PLCB2)
   04072 Phospholipase D signaling pathway
    108526885 (PLCB2)
   04071 Sphingolipid signaling pathway
    108526885 (PLCB2)
   04022 cGMP-PKG signaling pathway
    108526885 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108526885 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108526885 (PLCB2)
   04613 Neutrophil extracellular trap formation
    108526885 (PLCB2)
   04621 NOD-like receptor signaling pathway
    108526885 (PLCB2)
   04062 Chemokine signaling pathway
    108526885 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    108526885 (PLCB2)
   04922 Glucagon signaling pathway
    108526885 (PLCB2)
   04929 GnRH secretion
    108526885 (PLCB2)
   04912 GnRH signaling pathway
    108526885 (PLCB2)
   04915 Estrogen signaling pathway
    108526885 (PLCB2)
   04921 Oxytocin signaling pathway
    108526885 (PLCB2)
   04926 Relaxin signaling pathway
    108526885 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    108526885 (PLCB2)
   04918 Thyroid hormone synthesis
    108526885 (PLCB2)
   04919 Thyroid hormone signaling pathway
    108526885 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    108526885 (PLCB2)
   04916 Melanogenesis
    108526885 (PLCB2)
   04924 Renin secretion
    108526885 (PLCB2)
   04925 Aldosterone synthesis and secretion
    108526885 (PLCB2)
   04927 Cortisol synthesis and secretion
    108526885 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    108526885 (PLCB2)
   04270 Vascular smooth muscle contraction
    108526885 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    108526885 (PLCB2)
   04971 Gastric acid secretion
    108526885 (PLCB2)
   04972 Pancreatic secretion
    108526885 (PLCB2)
   04973 Carbohydrate digestion and absorption
    108526885 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    108526885 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    108526885 (PLCB2)
   04725 Cholinergic synapse
    108526885 (PLCB2)
   04728 Dopaminergic synapse
    108526885 (PLCB2)
   04726 Serotonergic synapse
    108526885 (PLCB2)
   04720 Long-term potentiation
    108526885 (PLCB2)
   04730 Long-term depression
    108526885 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    108526885 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    108526885 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    108526885 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    108526885 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108526885 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    108526885 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108526885 (PLCB2)
   05142 Chagas disease
    108526885 (PLCB2)
   05143 African trypanosomiasis
    108526885 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108526885 (PLCB2)
   05016 Huntington disease
    108526885 (PLCB2)
   05017 Spinocerebellar ataxia
    108526885 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    108526885 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108526885 (PLCB2)
   05415 Diabetic cardiomyopathy
    108526885 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    108526885 (PLCB2)
   04934 Cushing syndrome
    108526885 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rbb04131]
    108526885 (PLCB2)
Enzymes [BR:rbb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     108526885 (PLCB2)
Membrane trafficking [BR:rbb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    108526885 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    108526885 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y EF-hand_like C2 Gp58 Sde182_NH-like
Other DBs
NCBI-GeneID: 108526885
NCBI-ProteinID: XP_017723359
Position
Unknown
AA seq 954 aa
MSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLID
KYEPSGINVQRGQLSPEGMVWFLCGPENSVLAQDKLLLNHDMTQPLNHYFINSSHNTYLT
AGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIA
ESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRMIFGDMLLTEPLEKFPLKPGVPLPSPE
DLKGKILIKNKKNQFSTPTSSSKDPGGEAEGSSPRSAPAVWAGEEGTELEDDQVEEEEEE
ESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSF
TELKAYDLLSKAAVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMD
LPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSE
RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVM
EEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFVFLEMKDYVPGAWADLTVAL
ANPIKFFNAHDKRSEKLKEAMGGLPEKPFPLASPVASQVNGALAPRSNGSPEPRTASLEE
LRELKGVVKLQRRHEKELRELERRGVRRWEELLQRGAAQLAELGPRGAGGGGAGKLGPGK
GSRKKRSLPCEESAGAAPGEGPEGMDARVRELKDRLELELLRQGEEQYECVLKRKEQHAA
EQISKMMELAREKQAAELKALKEMAEIDTKEMKKKLETKRLEQIQGMTKVTTDKMAQERL
KREINNSHIQEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARM
KGLEAEVKESVRACFRTCFPSETKDKPERDCECPSELCERDPVIAKADAQESRL
NT seq 2865 nt   +upstreamnt  +downstreamnt
atgagcctctgtcctcggccagaaatagatgagatcttcacttcttaccatgctaaggcc
aaaccctacatgacgaaggagcacctgaccaaattcatcaaccagaaacagcgggactcc
cggcttaactccctgctgttcccgccagcacggcctgaccaggtgcagggcctcatcgac
aagtatgagcccagtggcatcaatgtgcagaggggccagctgtcacctgagggcatggtc
tggtttctctgtgggccggagaacagtgtgctggcccaggacaagctgctgctcaaccat
gacatgacacagccactcaatcattacttcatcaactcgtcccacaacacctacctgaca
gccggccagttctcaggcctctcctcggctgagatgtaccgccaggtgctgctgtccggc
tgccgttgcgtggagctagactgctggaaggggaaaccccctgacgaagagcccattatc
acccacggcttcaccatgaccacagacatcttcttcaaagaagcaattgaggctattgca
gaaagcgcctttaagacctccccctatcctatcatcctgtcatttgagaaccatgtggac
tcaccccgccagcaggctaagatggctgagtattgccggatgatcttcggggatatgctg
ctcacagagcccctggaaaagttcccactgaaaccaggtgtccccctgcccagccctgag
gatctcaagggcaagatcctcatcaagaacaagaagaaccagttttccacccccacctcc
tccagtaaggatcctggtggggaggctgagggcagcagcccacgcagtgcccctgcagtg
tgggctggcgaggaagggactgagctggaggacgaccaggtggaagaggaagaggaggag
gagtcaggaaacctggacgaagaagagattaagaagatgcagtcggatgagggcacagca
ggcctggaagtgacagcttatgaggagatgtccagcctagtgaattacattcagcccacc
aagttcatctcctttgagttctctgctcaaaagaaccgaagttatgtcatctcgtccttc
acagaactcaaggcatatgacctgctttccaaggccgcggtgcagtttgtggactacaac
aagcgccagatgagccgcatttaccccaagggaacccgcatggactcctccaactacatg
ccccagatgttctggaatgctggatgccagatggttgccctcaacttccagacgatggac
ttgcccatgcagcagaacatggcagtgtttgagttcaatgggcagagcggctacctcctc
aagcacgagttcatgcgccggccggacaagcagttcaaccccttctcagtggaccgcatc
gacgtggtggtggccaccaccctttctatcacggtgatctctgggcagttcctgtcagaa
cgcagtgtgcgcacctatgtggaagtggagctgtttggccttcctggggaccccaagagg
cgctatcgaactaagctgtcacccagtaccaattccattaatcctgtctggaaggaggag
ccctttgtctttgagaagatcttgatgcctgagctggcctctctcagggtggctgtgatg
gaggaaggcaacaagtttcttggacaccgcatcatccccatcaatgccctaaattctggg
taccaccacctgtgcctacacagtgagagcaacatgcccctcaccatgcctgcgctcttc
gtcttcctggagatgaaggactatgtacctggtgcctgggcagatctcactgtggccctc
gccaaccccatcaagttcttcaatgcccatgacaagaggtctgagaagctcaaggaggcc
atgggagggctgcctgagaagcccttcccactggcgagtccagttgccagccaggtcaat
ggtgcgttggccccaaggagcaatgggtcaccagagccacggaccgccagcctggaggag
ctccgggagctaaagggcgtcgtgaagctgcagcggcggcacgagaaggagctgcgggag
ttggagcggcgcggagtgcggcgctgggaggagctgctgcagcggggcgcggcgcagctg
gccgagctcgggccgcggggcgcggggggtggcggggccggcaagctcggcccgggcaaa
ggctctcgcaagaagaggagcctgccttgcgaggagagcgccggagccgcgccgggcgag
ggccctgagggcatggacgcgcgcgtgcgggagctgaaggacaggctggagctggagctg
ctgcggcagggcgaggagcagtacgagtgcgttctgaagcgcaaggagcagcacgcggcc
gagcaaatctccaaaatgatggagctggccagagagaaacaggcggcagagctgaaggcc
ctgaaggagatggcggagatcgacaccaaagagatgaagaaaaagctggagaccaagaga
ctggagcagatccagggcatgaccaaagtcaccacagataagatggcccaggagaggttg
aagagagagattaacaactcccacatccaggaagtggtgcaggtgatcaagcagatgaca
gagaacttggagaagcaccaggagaagctggaagagaagcaggctgcttgcctggaacag
atacgggagatggaaaagcagttccagaaggaggcgctggcagagtatgaggccaggatg
aagggtctggaggcagaggtgaaggagtcggtgagggcctgcttcaggacctgctttccc
tctgagaccaaggacaagcctgagagggactgcgagtgcccctcagagctgtgtgagcgg
gacccagtcatagcaaaggcagatgcccaggagagccgcctttga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (92)   

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