LOCUS       NP_001029285             594 aa            linear   PRI 03-APR-2023
DEFINITION  glutamate decarboxylase 1 [Pan troglodytes].
ACCESSION   NP_001029285 XP_523946
VERSION     NP_001029285.1
DBSOURCE    REFSEQ: accession NM_001034113.1
KEYWORDS    RefSeq.
SOURCE      Pan troglodytes (chimpanzee)
  ORGANISM  Pan troglodytes
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pan.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Dorus S, Vallender EJ, Evans PD, Anderson JR, Gilbert SL, Mahowald
            M, Wyckoff GJ, Malcom CM and Lahn BT.
  TITLE     Accelerated evolution of nervous system genes in the origin of Homo
            sapiens
  JOURNAL   Cell 119 (7), 1027-1040 (2004)
   PUBMED   15620360
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY665260.1.
            
            On Oct 14, 2005 this sequence version replaced XP_523946.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY665260.1, SRR6713217.12213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02045701, SAMN02297901
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Pan troglodytes"
                     /db_xref="taxon:9598"
                     /chromosome="2B"
                     /map="2B"
     Protein         1..594
                     /product="glutamate decarboxylase 1"
                     /EC_number="4.1.1.15"
                     /note="67 kDa glutamic acid decarboxylase; glutamate
                     decarboxylase 1 (brain, 67kDa)"
                     /calculated_mol_wt=66767
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5IS68.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48318; propagated from
                     UniProtKB/Swiss-Prot (Q5IS68.1)"
     Region          144..518
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(252..253,256,344,373,376,402,405)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            405
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..594
                     /gene="GAD1"
                     /gene_synonym="GAD-67"
                     /coded_by="NM_001034113.1:1..1785"
                     /db_xref="GeneID:468557"
                     /db_xref="VGNC:VGNC:436"
ORIGIN      
        1 masstpsssa tssnagadpn ttnlrpttyd twcgvahgct rklglkicgf lqrtnsleek
       61 srlvsafker qssknllsce nsdrdarfrr tetdfsnlfa rdllpaknge eqtvqfllev
      121 vdillnyvrk tfdrstkvld fhhphqlleg megfnlelsd hpesleqilv dcrdtlkygv
      181 rtghprffnq lstgldiigl agewltstan tnmftyeiap vfvlmeqitl kkmreiigws
      241 skdgdgifsp ggaisnmysi maarykyfpe vktkgmaavp klvlftseqs hysikkagaa
      301 lgfgtdnvil ikcnergkii padfeakile akqkgyvpfy vnatagttvy gafdpiqeia
      361 dicekynlwl hvdaawgggl lmsrkhrhkl ngieransvt wnphkmmgvl lqcsailike
      421 kgilqgcnqm cagylfqpdk qydvsydtgd kaiqcgrhvd ifkfwlmwka kgtvgfesqi
      481 nkclelaeyl yakiknreef emvfngepeh tnvcfwyipq slrgvpdspq rreklhkvap
      541 kikalmmesg ttmvgyqpqg dkanffrmvi snpaatqsdi dflieeierl gqdl
//