LOCUS NP_001101159 2918 aa linear ROD 12-DEC-2023
DEFINITION histone-lysine N-methyltransferase ASH1L [Rattus norvegicus].
ACCESSION NP_001101159 XP_001074246 XP_227409
VERSION NP_001101159.1
DBSOURCE REFSEQ: accession NM_001107689.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 2918)
AUTHORS Zeng J, Gao W, Tang Y, Wang Y, Liu X, Yin J, Su X, Zhang M, Kang E,
Tian Y, Ni B and He W.
TITLE Hypoxia-sensitive cells trigger NK cell activation via the
KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat
epididymis
JOURNAL Cell Rep 42 (11), 113442 (2023)
PUBMED 37952156
REMARK GeneRIF: Hypoxia-sensitive cells trigger NK cell activation via the
KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat
epididymis.
REFERENCE 2 (residues 1 to 2918)
AUTHORS Brinkmeier ML, Geister KA, Jones M, Waqas M, Maillard I and Camper
SA.
TITLE The Histone Methyltransferase Gene Absent, Small, or Homeotic
Discs-1 Like Is Required for Normal Hox Gene Expression and
Fertility in Mice
JOURNAL Biol Reprod 93 (5), 121 (2015)
PUBMED 26333994
REFERENCE 3 (residues 1 to 2918)
AUTHORS Eram MS, Kuznetsova E, Li F, Lima-Fernandes E, Kennedy S, Chau I,
Arrowsmith CH, Schapira M and Vedadi M.
TITLE Kinetic characterization of human histone H3 lysine 36
methyltransferases, ASH1L and SETD2
JOURNAL Biochim Biophys Acta 1850 (9), 1842-1848 (2015)
PUBMED 26002201
REFERENCE 4 (residues 1 to 2918)
AUTHORS Atta H, El-Rehany M, Hammam O, Abdel-Ghany H, Ramzy M, Roderfeld M,
Roeb E, Al-Hendy A, Raheim SA, Allam H and Marey H.
TITLE Mutant MMP-9 and HGF gene transfer enhance resolution of
CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2
methyltransferases repression
JOURNAL PLoS One 9 (11), e112384 (2014)
PUBMED 25380300
REMARK GeneRIF: Data show that Ash1l and EZH2 methyltransferases protein
expression was significantly elevated in fibrotic liver and
decreased in mutant matrix metalloproteinase-9 (mMMP-9) and human
hepatocyte growth factor (hHGF) gene transfer treated fibrotic
livers.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 2918)
AUTHORS Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang
J, Xu T and Cao X.
TITLE Histone methyltransferase Ash1l suppresses interleukin-6 production
and inflammatory autoimmune diseases by inducing the
ubiquitin-editing enzyme A20
JOURNAL Immunity 39 (3), 470-481 (2013)
PUBMED 24012418
REFERENCE 6 (residues 1 to 2918)
AUTHORS Black JC, Van Rechem C and Whetstine JR.
TITLE Histone lysine methylation dynamics: establishment, regulation, and
biological impact
JOURNAL Mol Cell 48 (4), 491-507 (2012)
PUBMED 23200123
REMARK Review article
REFERENCE 7 (residues 1 to 2918)
AUTHORS Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter
FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D,
Lachner M and Jenuwein T.
TITLE Prdm3 and Prdm16 are H3K9me1 methyltransferases required for
mammalian heterochromatin integrity
JOURNAL Cell 150 (5), 948-960 (2012)
PUBMED 22939622
REFERENCE 8 (residues 1 to 2918)
AUTHORS Girard A, Sachidanandam R, Hannon GJ and Carmell MA.
TITLE A germline-specific class of small RNAs binds mammalian Piwi
proteins
JOURNAL Nature 442 (7099), 199-202 (2006)
PUBMED 16751776
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JACYVU010000069.1.
On or before Oct 4, 2007 this sequence version replaced
XP_001074246.1, XP_227409.4.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMD00132263,
SAMD00132265 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..2918
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="2"
/map="2q34"
Protein 1..2918
/product="histone-lysine N-methyltransferase ASH1L"
/EC_number="2.1.1.354"
/note="probable histone-lysine N-methyltransferase ASH1L;
ash1 (absent, small, or homeotic)-like"
/calculated_mol_wt=326343
Region 2042..2093
/region_name="AWS"
/note="associated with SET domains; smart00570"
/db_xref="CDD:197795"
Region 2096..2236
/region_name="SET_ASH1L"
/note="SET domain (including post-SET domain) found in
ASH1-like protein (ASH1L) and similar proteins; cd19174"
/db_xref="CDD:380951"
Site order(2105..2107,2124,2134,2138,2146..2152,2169..2173,
2180..2182,2197,2208..2216,2221..2225,2234)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:380951"
Site order(2105..2107,2146..2149,2169..2173,2210,2221..2225,
2234)
/site_type="other"
/note="SAM binding site"
/db_xref="CDD:380951"
Site order(2124,2134,2138,2148..2152,2180..2182,2197,
2208..2212)
/site_type="other"
/note="putative polypeptide substrate binding site
[polypeptide binding]"
/db_xref="CDD:380951"
Site order(2175,2223,2225,2230)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:380951"
Region 2392..2497
/region_name="Bromo_ASH1"
/note="Bromodomain; ASH1_like sub-family. ASH1 (absent,
small, or homeotic 1) is a member of the trithorax-group
in Drosophila melanogaster, an epigenetic transcriptional
regulator of HOX genes. Drosophila ASH1 has been shown to
methylate specific lysines in...; cd05525"
/db_xref="CDD:99955"
Site order(2424,2429,2432,2471,2475,2481)
/site_type="other"
/note="putative acetyllysine binding site [chemical
binding]"
/db_xref="CDD:99955"
Region 2535..2577
/region_name="PHD_ASH1L"
/note="PHD finger found in histone-lysine
N-methyltransferase ASH1L; cd15548"
/db_xref="CDD:277023"
Site order(2536,2547..2551,2555,2572)
/site_type="other"
/note="putative histone H3 binding site [polypeptide
binding]"
/db_xref="CDD:277023"
Region 2614..2748
/region_name="BAH_polybromo"
/note="BAH, or Bromo Adjacent Homology domain, as present
in polybromo and yeast RSC1/2. The human polybromo protein
(BAF180) is a component of the SWI/SNF
chromatin-remodeling complex PBAF. It is thought that
polybromo participates in transcriptional...; cd04717"
/db_xref="CDD:240068"
CDS 1..2918
/gene="Ash1l"
/coded_by="NM_001107689.2:258..9014"
/db_xref="GeneID:310638"
/db_xref="RGD:1306350"
ORIGIN
1 mdprntamlg lgsdsegfsr kspsaissgt laskreveie gntdeedprk rnreraieag
61 kddgltdaqq qfsvketnfs egnlklkigl qakrtkkppk nlenyvcrpa ikttvkhsrk
121 alksgkmtde knehcpskwd ssklfkkagd ataiecqsee svhlhsqgen nplskklspv
181 hsqmadyipa applvgsrdp dikdrallng gtsvteklaq liatcppsks skakpkklgt
241 gttvglvskd lirkpgvgsi agiihkdlik kpalstavgl vtkdpgkkpm fnaavslink
301 dsvkklgtgt tavfinkdlg kkpgtvttvg llskdpgkkl gigivpglvn kesgkklglg
361 tvvglvnkel gkklsstvgl vakdvtkkiv assamglvnk digkkllscp iagqlgskda
421 lnlkseallp tqeqlkascs anisnhesqe lpeslkdsat sktfeknvmr hskesmlekf
481 svrkeitnle kemfnegtci qqdsfssner gafetskhek qppvyctspd fqiggasdas
541 takspfgavg esnlpssspt vsvnpltrnp petssqlvpn plllnstaeq meeisesigk
601 nqftaesthl nvghrslghs isieckgidk elnesksthl disrissslg kkpslasdsg
661 ihtitpsvvn ftslfsnkpf lklgavaapd khcqvaesls tsfqskplkk rkgrkarwtk
721 vvarstcrsp kgldlersel fknvscssls nssepakfmk tigassfvdh dflkrrlpkl
781 skssapslal ladsekashk sfithklsss mcvtsdllsd iykpkrgrpk skempqlegp
841 pkrtlkipas kvfslqskee qeppilqpei eipsfkqsls vspfpkkrgr pkrqmrspvk
901 mkppvlsvap fvatespskl esesenhrss sdffesedql qdtddledsh rqsvcsvsdl
961 emepdkkisk rnngqlmkti irkinkmktl krkkllnqil sssvessnkg kvqsklhntv
1021 sslaatfgsk lgqqinvskk gtiyigkrrg rkpktvlngl lsgspaslav leqtaqqaag
1081 salgqilppl lpspasssei lpspicsqss gtsggqspvs sdagfvepss vpylhvhsrq
1141 gsmiqtlamk kaakgrrrls pptllpnsps hlseltslke atpspvsesh sdetipsdsg
1201 igtdnnstsd raekfcgqkk rrhsfehisl ippetstvln slkekhkhkc krrshdylsy
1261 dkmkrqkrkr kkkypqlrnr qdpdfiaele elisrlseir ithrshhfip rdllptifri
1321 nfnsfythps fpldplhyir kpdlkkkrgr ppkmreamae mpfmhslsfp lsstgfypsy
1381 gmpyspsplt aapiglgyyg rypptlyppp pspsfttplp ppsymhaghl llnptkyhkk
1441 khkllrqeaf lttsrtplls mstypsvppe maygwmvehk hrhrhkhreh rseqpqvsmd
1501 tgssrsvles lkryrfgkdt vgdrykhkek hrchmscphl spskslinre eqwvsrepse
1561 ssslalglqt plqidcsess pslslggftp nsepassdeh mnlftsaigs crvsnpnssc
1621 rkkltdspgl fpvqdtalsr phrkeplpst eraiqslags qsasdkpsqr ssestncspt
1681 rkrsssests stvngipsrs prlvasldds vdcllqrivq hdeqesvekn gdapittvsa
1741 ppssspghsy skertlgksd sllvpavpsd scnsipllse klasrcsphh ikrsvveamq
1801 rqarkmcnyd kilatkknld hvnkilkakk lqrqartgnn fvkrrpgrpr kcplqavvsm
1861 qafqaaqfvn pelnegeevs lhlspdtvtd vieavvqsvn lnsehkkgwk rknwlleeqt
1921 rkkqktvpee eeqennksfi ekpveipspl etpaepsepe snlqpvlali prekkaprpp
1981 kkkyqragly sdvykttdpk srliqlkkek leytpgehey glfpapihvd vyvdvkplsg
2041 yeattcnckk pdddtrkgcg ddclnrmifa ecspntcpcg eqccnqriqr hewvqclerf
2101 raeekgwgir tkeplkagqf iieylgevvs eqefrnrmie qyhnhsdhyc lnldsgmvid
2161 syrmgnearf inhscdpnce mqkwsvngvy riglyalkdv pagteltydy nfhsfnvekq
2221 qlckcgfekc rgiiggksqr mnglpshkgs qpasthrksa rskekrkskh klkkrrghps
2281 eepsenintp trltpqlqmk pmsnrernfv lkhhvflvrn wekihqkqee vkhsrdihst
2341 slytrwngic rddgniksdv fmtqfsalqt arsvrtrrla aaeenlevar aarlaqifke
2401 icdgiisykd ssqqalaapl lnlppkkkna dyyekisdpl dlstiekqil tgyyktveaf
2461 dadmlkvfrn aekyygrksp igrdvcrlrk ayysarheas aqideivget aseadssets
2521 vsekenshek dddvircicg lykdeglmiq cdkcmvwqhc dcmgvntdve hylceqcdpr
2581 pvdrevpmip rphyaqpgcv yficllrddl llrqgdcvyl mrdsrrtpdg hpvrqsyrll
2641 shinrdkldi frieklwkne keerfafghh yfrphethhs psrrfyhnel frvplyeiip
2701 leavvgtccv ldlytyckgr pkgvkeqdvy icdyrldksa hlfykihrnr ypvctkpyaf
2761 dhfpkkltpk rdfsphyvpd nykrnggrss wkserskpll kdlgqdddal plieevlasq
2821 eqaanempsp eepdqervtg dvsdaekkpe essqepqlas tpeerrhsqr erlnqillnl
2881 lekipgknai dvtylleegs grklrrrtlf ipensfrk
//
