LOCUS       NP_001180740             271 aa            linear   PRI 11-JUL-2020
DEFINITION  peroxiredoxin-4 precursor [Macaca mulatta].
ACCESSION   NP_001180740 XP_001087492
VERSION     NP_001180740.1
DBSOURCE    REFSEQ: accession NM_001193811.2
KEYWORDS    RefSeq.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (residues 1 to 271)
  AUTHORS   Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S,
            Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Marcais G,
            Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA
            and Norgren RB Jr.
  TITLE     A new rhesus macaque assembly and annotation for next-generation
            sequencing analyses
  JOURNAL   Biol. Direct 9 (1), 20 (2014)
   PUBMED   25319552
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 271)
  AUTHORS   Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li
            Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson
            JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J,
            Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N,
            Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B,
            Nielsen R, Yang H, Wang J, Wang X and Wang J.
  TITLE     Genome sequencing and comparison of two nonhuman primate animal
            models, the cynomolgus and Chinese rhesus macaques
  JOURNAL   Nat. Biotechnol. 29 (11), 1019-1023 (2011)
   PUBMED   22002653
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            QNVO02003165.1.
            
            On Aug 11, 2010 this sequence version replaced XP_001087492.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: JV566744.1, CO579602.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support SAMEA4688315,
                                    SAMEA4688316 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Macaca mulatta"
                     /db_xref="taxon:9544"
                     /chromosome="X"
                     /map="X"
     Protein         1..271
                     /product="peroxiredoxin-4 precursor"
                     /EC_number="1.11.1.15"
                     /note="Peroxiredoxin-4"
                     /calculated_mol_wt=26558
     sig_peptide     1..37
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3961
     Region          81..252
                     /region_name="PRX_Typ2cys"
                     /note="Peroxiredoxin (PRX) family, Typical 2-Cys PRX
                     subfamily; PRXs are thiol-specific antioxidant (TSA)
                     proteins, which confer a protective role in cells through
                     its peroxidase activity by reducing hydrogen peroxide,
                     peroxynitrite, and organic hydroperoxides; cd03015"
                     /db_xref="CDD:239313"
     Site            order(81,122..123,126,189,199,212..214,216..218,222..223,
                     230,245..248)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239313"
     Site            order(120,154..155,180,182,194)
                     /site_type="other"
                     /note="decamer (pentamer of dimers) interface [polypeptide
                     binding]"
                     /db_xref="CDD:239313"
     Site            order(121,124,200)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:239313"
     Site            order(124,245)
                     /site_type="active"
                     /note="peroxidatic and resolving cysteines [active]"
                     /db_xref="CDD:239313"
     CDS             1..271
                     /gene="PRDX4"
                     /coded_by="NM_001193811.2:114..929"
                     /db_xref="GeneID:697635"
                     /db_xref="VGNC:VGNC:76272"
ORIGIN      
        1 mealpllaat tpaqgrhrrl lllplllfll pagavrgwet edrprtreee chfyaggqvy
       61 pgeasrvsva dhslhlskak iskpapyweg tavidgefke lkltdyrgky lvfffypldf
      121 tfvcpteiia fgdrleefrs intevvacsv dsqfthlawi ntprrqgglg piripllsdl
      181 thqiskdygv yledsghtlr glfiiddkgi lrqitlndlp vgrsvdetlr lvqafqytdk
      241 hgevcpagwk pgsetiipdp agklkyfdkl n
//