LOCUS NP_001239484 161 aa linear ROD 12-SEP-2023
DEFINITION maleylacetoacetate isomerase isoform 2 [Mus musculus].
ACCESSION NP_001239484
VERSION NP_001239484.1
DBSOURCE REFSEQ: accession NM_001252555.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 161)
AUTHORS Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K and Tang N.
TITLE GSTZ1 sensitizes hepatocellular carcinoma cells to
sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
JOURNAL Cell Death Dis 12 (5), 426 (2021)
PUBMED 33931597
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 161)
AUTHORS Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K
and Tang N.
TITLE GSTZ1 deficiency promotes hepatocellular carcinoma proliferation
via activation of the KEAP1/NRF2 pathway
JOURNAL J Exp Clin Cancer Res 38 (1), 438 (2019)
PUBMED 31666108
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 161)
AUTHORS Yang F, Li J, Deng H, Wang Y, Lei C, Wang Q, Xiang J, Liang L, Xia
J, Pan X, Li X, Long Q, Chang L, Xu P, Huang A, Wang K and Tang N.
TITLE GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via
Accumulation of Oncometabolite Succinylacetone
JOURNAL EMBO J 38 (15), e101964 (2019)
PUBMED 31267557
REFERENCE 4 (residues 1 to 161)
AUTHORS Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura
A, Kaitsuka T, Takeya M, Oike Y, Suzuki T and Tomizawa K.
TITLE Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
Required for Mitochondrial Translation and Is Involved in
Reversible Infantile Liver Injury
JOURNAL PLoS Genet 12 (9), e1006355 (2016)
PUBMED 27689697
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 161)
AUTHORS Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
Flicek P, Skarnes WC, Mallon AM and Parkinson H.
TITLE The International Mouse Phenotyping Consortium Web Portal, a
unified point of access for knockout mice and related phenotyping
data
JOURNAL Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
PUBMED 24194600
REFERENCE 6 (residues 1 to 161)
AUTHORS Lim CE, Matthaei KI, Blackburn AC, Davis RP, Dahlstrom JE, Koina
ME, Anders MW and Board PG.
TITLE Mice deficient in glutathione transferase zeta/maleylacetoacetate
isomerase exhibit a range of pathological changes and elevated
expression of alpha, mu, and pi class glutathione transferases
JOURNAL Am J Pathol 165 (2), 679-693 (2004)
PUBMED 15277241
REFERENCE 7 (residues 1 to 161)
AUTHORS Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
Mann M.
TITLE Integrated analysis of protein composition, tissue diversity, and
gene regulation in mouse mitochondria
JOURNAL Cell 115 (5), 629-640 (2003)
PUBMED 14651853
REFERENCE 8 (residues 1 to 161)
AUTHORS Ammini CV, Fernandez-Canon J, Shroads AL, Cornett R, Cheung J,
James MO, Henderson GN, Grompe M and Stacpoole PW.
TITLE Pharmacologic or genetic ablation of maleylacetoacetate isomerase
increases levels of toxic tyrosine catabolites in rodents
JOURNAL Biochem Pharmacol 66 (10), 2029-2038 (2003)
PUBMED 14599561
REFERENCE 9 (residues 1 to 161)
AUTHORS Fernandez-Canon JM, Baetscher MW, Finegold M, Burlingame T, Gibson
KM and Grompe M.
TITLE Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a
glutathione-dependent nonenzymatic bypass in tyrosine catabolism
JOURNAL Mol Cell Biol 22 (13), 4943-4951 (2002)
PUBMED 12052898
REMARK GeneRIF: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice
reveal a glutathione-dependent nonenzymatic bypass in tyrosine
catabolism
REFERENCE 10 (residues 1 to 161)
AUTHORS Fernandez-Canon JM, Hejna J, Reifsteck C, Olson S and Grompe M.
TITLE Gene structure, chromosomal location, and expression pattern of
maleylacetoacetate isomerase
JOURNAL Genomics 58 (3), 263-269 (1999)
PUBMED 10373324
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AB041613.1, AK075927.1 and AA244513.1.
Transcript Variant: This variant (2) differs in the 5' UTR and has
a downstream AUG start codon, compared to variant 1. The resulting
isoform (2) has a shorter N-terminus, compared to isoform 1.
Variants 2 and 3 encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB041613.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164139 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..161
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="12"
/map="12 41.34 cM"
Protein 1..161
/product="maleylacetoacetate isomerase isoform 2"
/EC_number="2.5.1.18"
/EC_number="5.2.1.2"
/note="glutathione S-transferase zeta 1;
maleylacetoacetate isomerase"
/calculated_mol_wt=17855
Region <1..156
/region_name="maiA"
/note="maleylacetoacetate isomerase; TIGR01262"
/db_xref="CDD:273527"
CDS 1..161
/gene="Gstz1"
/gene_synonym="GSTZ1-1; MAAI"
/coded_by="NM_001252555.1:592..1077"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS88379.1"
/db_xref="GeneID:14874"
/db_xref="MGI:MGI:1341859"
ORIGIN
1 mkqvpalkid gitivqslai meyleetrpi prllpqdpqk raivrmisdl iasgiqplqn
61 lsvlkqvgqe nqmqwaqkvi tsgfnaleki lqstagkycv gdevsmadvc lvpqvanaer
121 fkvdlspypt ishinkella levfqvshpr rqpdtpaelr t
//
