LOCUS NP_001307280 1469 aa linear PRI 04-DEC-2023
DEFINITION transient receptor potential cation channel subfamily M member 2
isoform 3 [Homo sapiens].
ACCESSION NP_001307280 XP_006724112
VERSION NP_001307280.2
DBSOURCE REFSEQ: accession NM_001320351.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1469)
AUTHORS Cheng K, Jia Q, Batbatan C, Guo Z and Cheng F.
TITLE TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor
Growth in Prostate Cancer by Hypoxia-Inducible Factor-1alpha
JOURNAL J Interferon Cytokine Res 43 (11), 495-511 (2023)
PUBMED 37906101
REMARK GeneRIF: TRPM2-L Participates in the Interleukin-6 Pathway to
Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible
Factor-1alpha.
REFERENCE 2 (residues 1 to 1469)
AUTHORS Xiang X, Hu Y, Song Z and Wang C.
TITLE Knockdown of TRPM2 promotes osteogenic differentiation of human
periodontal ligament stem cells by modulating NF-kappaB /NLRP3
pathway
JOURNAL Tissue Cell 84, 102184 (2023)
PUBMED 37541115
REMARK GeneRIF: Knockdown of TRPM2 promotes osteogenic differentiation of
human periodontal ligament stem cells by modulating NF-kappaB
/NLRP3 pathway.
REFERENCE 3 (residues 1 to 1469)
AUTHORS Zhang M, Wang Y, Xu S, Huang S, Wu M, Chen G and Wang Y.
TITLE Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier
for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A
Potential Therapeutic Target of Ovarian Cancer
JOURNAL Int J Mol Sci 24 (18), 14010 (2023)
PUBMED 37762313
REMARK GeneRIF: Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk
Classifier for Survival Evaluation in Epithelial Ovarian Cancer and
TRPM2: A Potential Therapeutic Target of Ovarian Cancer.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1469)
AUTHORS Ali ES, Chakrabarty B, Ramproshad S, Mondal B, Kundu N, Sarkar C,
Sharifi-Rad J, Calina D and Cho WC.
TITLE TRPM2-mediated Ca2+ signaling as a potential therapeutic target in
cancer treatment: an updated review of its role in survival and
proliferation of cancer cells
JOURNAL Cell Commun Signal 21 (1), 145 (2023)
PUBMED 37337283
REMARK GeneRIF: TRPM2-mediated Ca[2+] signaling as a potential therapeutic
target in cancer treatment: an updated review of its role in
survival and proliferation of cancer cells.
Review article
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 1469)
AUTHORS Yuan H, Li W, Lou N, Yu T, Meng X, Xiao W and Zhang X.
TITLE TRPM2 facilitates tumor progression of clear cell renal cell
carcinoma by relieving Endoplasmic Reticulum Stress
JOURNAL Int J Med Sci 20 (1), 57-69 (2023)
PUBMED 36619219
REMARK GeneRIF: TRPM2 facilitates tumor progression of clear cell renal
cell carcinoma by relieving Endoplasmic Reticulum Stress.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 1469)
AUTHORS Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H and
Furuichi K.
TITLE Immunocyte Ca2+ influx system mediated by LTRPC2
JOURNAL Science 293 (5533), 1327-1330 (2001)
PUBMED 11509734
REFERENCE 7 (residues 1 to 1469)
AUTHORS Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L and Zhu MX.
TITLE Identification of common binding sites for calmodulin and inositol
1,4,5-trisphosphate receptors on the carboxyl termini of trp
channels
JOURNAL J Biol Chem 276 (24), 21303-21310 (2001)
PUBMED 11290752
REFERENCE 8 (residues 1 to 1469)
AUTHORS Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C,
Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP and Scharenberg
AM.
TITLE ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed
by Nudix motif homology
JOURNAL Nature 411 (6837), 595-599 (2001)
PUBMED 11385575
REFERENCE 9 (residues 1 to 1469)
AUTHORS Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F and
Shimizu N.
TITLE Molecular cloning of a novel putative Ca2+ channel protein (TRPC7)
highly expressed in brain
JOURNAL Genomics 54 (1), 124-131 (1998)
PUBMED 9806837
REFERENCE 10 (residues 1 to 1469)
AUTHORS Kudoh J, Nagamine K, Asakawa S, Abe I, Kawasaki K, Maeda H,
Tsujimoto S, Minoshima S, Ito F and Shimizu N.
TITLE Localization of 16 exons to a 450-kb region involved in the
autoimmune polyglandular disease type I (APECED) on human
chromosome 21q22.3
JOURNAL DNA Res 4 (1), 45-52 (1997)
PUBMED 9179495
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AP001063.1, AP001064.1 and
AP001065.1.
On Nov 18, 2020 this sequence version replaced NP_001307280.1.
Summary: The protein encoded by this gene forms a tetrameric cation
channel that is permeable to calcium, sodium, and potassium and is
regulated by free intracellular ADP-ribose. The encoded protein is
activated by oxidative stress and confers susceptibility to cell
death. Alternative splicing results in multiple transcript variants
encoding distinct protein isoforms. Additional transcript variants
of this gene have been described, but their full-length nature is
not known. [provided by RefSeq, Feb 2016].
Transcript Variant: This variant (4) lacks an in-frame exon in the
3' coding region, compared to variant 1, which results in a shorter
isoform (3), compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038192.1974215.1,
SRR14038191.334745.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1469
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="21"
/map="21q22.3"
Protein 1..1469
/product="transient receptor potential cation channel
subfamily M member 2 isoform 3"
/EC_number="3.6.1.13"
/note="transient receptor potential channel 7; long
transient receptor potential channel 2;
estrogen-responsive element-associated gene 1 protein;
transient receptor potential melastatin 2"
/calculated_mol_wt=167286
Region 141..364
/region_name="LSDAT_euk"
/note="SLOG in TRPM; cl39032"
/db_xref="CDD:453937"
Region 803..>979
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:425730"
Region 1292..1465
/region_name="ADPRase_NUDT9"
/note="ADP-ribose pyrophosphatase (ADPRase) catalyzes the
hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other
members of the Nudix hydrolase superfamily of enzymes, it
is thought to require a divalent cation, such as Mg2+, for
its activity. It also...; cd03670"
/db_xref="CDD:239642"
Site order(1315,1345,1355,1371,1395,1397,1399,1451,1454)
/site_type="active"
/db_xref="CDD:239642"
Site 1356..1378
/site_type="other"
/note="nudix motif"
/db_xref="CDD:239642"
CDS 1..1469
/gene="TRPM2"
/gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
NUDT9L1; TRPC7"
/coded_by="NM_001320351.2:81..4490"
/note="isoform 3 is encoded by transcript variant 4"
/db_xref="GeneID:7226"
/db_xref="HGNC:HGNC:12339"
/db_xref="MIM:603749"
ORIGIN
1 mepsalrkag seqeegfegl prrvtdlgmv snlrrsnssl fkswrlqcpf gnndkqesls
61 swipenikkk ecvyfvessk lsdagkvvcq cgytheqhle eatkphtfqg tqwdpkkhvq
121 emptdafgdi vftglsqkvk kyvrvsqdtp ssviyhlmtq hwgldvpnll isvtggaknf
181 nmkprlksif rrglvkvaqt tgawiitggs htgvmkqvge avrdfslsss ykegelitig
241 vatwgtvhrr eglihptgsf paeyildedg qgnltcldsn hshfilvddg thgqygveip
301 lrtrlekfis eqtkerggva ikipivcvvl eggpgtlhti dnattngtpc vvvegsgrva
361 dviaqvanlp vsditisliq qklsvffqem fetftesriv ewtkkiqdiv rrrqlltvfr
421 egkdgqqdvd vailqallka srsqdhfghe nwdhqlklav awnrvdiars eifmdewqwk
481 psdlhptmta alisnkpefv klflengvql kefvtwdtll ylyenldpsc lfhsklqkvl
541 vedperpaca paaprlqmhh vaqvlrellg dftqplyprp rhndrlrlll pvphvklnvq
601 gvslrslykr ssghvtftmd pirdlliwai vqnrrelagi iwaqsqdcia aalacskilk
661 elskeeedtd sseemlalae eyehraigvf tecyrkdeer aqklltrvse awgkttclql
721 aleakdmkfv shggiqaflt kvwwgqlsvd nglwrvtlcm lafpllltgl isfrekrlqd
781 vgtpaarara fftapvvvfh lnilsyfafl clfayvlmvd fqpvpswcec aiylwlfslv
841 ceemrqlfyd pdecglmkka alyfsdfwnk ldvgaillfv agltcrlipa tlypgrvils
901 ldfilfclrl mhiftisktl gpkiiivkrm mkdvffflfl lavwvvsfgv akqailihne
961 rrvdwlfrga vyhsyltifg qipgyidgvn fnpehcspng tdpykpkcpe sdatqqrpaf
1021 pewltvlllc lyllftnill lnlliamfny tfqqvqehtd qiwkfqrhdl ieeyhgrpaa
1081 pppfillshl qlfikrvvlk tpakrhkqlk nklekneeaa llsweiylke nylqnrqfqq
1141 kqrpeqkied isnkvdamvd lldldplkrs gsmeqrlasl eeqvaqtaqa lhwivrtlra
1201 sgfsseadvp tlasqkaaee pdaepggrkk teepgdsyhv narhllypnc pvtrfpvpne
1261 kvpwetefli ydppfytaer kdaaamdpmg enpmgrtglr grgslscfgp nhtlypmvtr
1321 wrrnedgaic rksikkmlev lvvklplseh walpggsrep gemlprklkr ilrqehwpsf
1381 enllkcgmev ykgymddprn tdnawietva vsvhfqdqnd velnrlnsnl hacdsgasir
1441 wqvvdrripl yanhktllqk aaaefgahy
//
