LOCUS NP_001334519 263 aa linear ROD 12-NOV-2023
DEFINITION dorsal root ganglia homeobox protein isoform 1 [Mus musculus].
ACCESSION NP_001334519 XP_006518473
VERSION NP_001334519.1
DBSOURCE REFSEQ: accession NM_001347590.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 263)
AUTHORS Lowenstein ED, Ruffault PL, Misios A, Osman KL, Li H, Greenberg RS,
Thompson R, Song K, Dietrich S, Li X, Vladimirov N, Woehler A,
Brunet JF, Zampieri N, Kuhn R, Liberles SD, Jia S, Lewin GR,
Rajewsky N, Lever TE and Birchmeier C.
TITLE Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
JOURNAL Neuron 111 (14), 2184-2200 (2023)
PUBMED 37192624
REFERENCE 2 (residues 1 to 263)
AUTHORS Hernandez-Miranda LR, Ibrahim DM, Ruffault PL, Larrosa M, Balueva
K, Muller T, Weerd W, Stolte-Dijkstra I, Hostra RMW, Brunet JF,
Fortin G, Mundlos S and Birchmeier C.
TITLE Mutation in LBX1/Lbx1 precludes transcription factor cooperativity
and causes congenital hypoventilation in humans and mice
JOURNAL Proc Natl Acad Sci U S A 115 (51), 13021-13026 (2018)
PUBMED 30487221
REFERENCE 3 (residues 1 to 263)
AUTHORS Soares-Dos-Reis R, Pessoa AS, Dias AF, Falcao M, Matos MR, Vitorino
R, Monteiro FA, Lima D and Reguenga C.
TITLE A role for prolyl isomerase PIN1 in the phosphorylation-dependent
modulation of PRRXL1 function
JOURNAL Biochem J 474 (5), 683-697 (2017)
PUBMED 28049756
REMARK GeneRIF: The findings provide evidence for a putative novel role of
PIN1 in the development of the nociceptive system and indicate
phosphorylation-mediated conformational changes as a mechanism for
regulating the PRRXL1 role in the process.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 263)
AUTHORS Monteiro C, Cardoso-Cruz H, Matos M, Dourado M, Lima D and Galhardo
V.
TITLE Increased fronto-hippocampal connectivity in the Prrxl1 knockout
mouse model of congenital hypoalgesia
JOURNAL Pain 157 (9), 2045-2056 (2016)
PUBMED 27168359
REMARK GeneRIF: The results of this study suggest that Prrxl1 knockout
mouse model of congenital hypoalgesia may have an effect on brain
plasticity that is the inverse of what is usually observed in
animal models of chronic pain.
REFERENCE 5 (residues 1 to 263)
AUTHORS Monteiro CB, Midao L, Rebelo S, Reguenga C, Lima D and Monteiro FA.
TITLE Zinc finger transcription factor Casz1 expression is regulated by
homeodomain transcription factor Prrxl1 in embryonic spinal dorsal
horn late-born excitatory interneurons
JOURNAL Eur J Neurosci 43 (11), 1449-1459 (2016)
PUBMED 26913565
REMARK GeneRIF: Study shows that Casz1 lies downstream of Prrxl1 in the
differentiation pathway of a large subset of dorsal late-born
excitatory neurons and provides a framework for further studies of
Casz1 in assembly of the dorsal root ganglion-spinal circuit.
REFERENCE 6 (residues 1 to 263)
AUTHORS Samad TA, Srinivasan A, Karchewski LA, Jeong SJ, Campagna JA, Ji
RR, Fabrizio DA, Zhang Y, Lin HY, Bell E and Woolf CJ.
TITLE DRAGON: a member of the repulsive guidance molecule-related family
of neuronal- and muscle-expressed membrane proteins is regulated by
DRG11 and has neuronal adhesive properties
JOURNAL J Neurosci 24 (8), 2027-2036 (2004)
PUBMED 14985445
REMARK GeneRIF: transcriptionally regulates DRAGON; coexpressed with
DRAGON in embryonic dorsal root ganglion and spinal cord
REFERENCE 7 (residues 1 to 263)
AUTHORS Ding YQ, Yin J, Xu HM, Jacquin MF and Chen ZF.
TITLE Formation of whisker-related principal sensory nucleus-based
lemniscal pathway requires a paired homeodomain transcription
factor, Drg11
JOURNAL J Neurosci 23 (19), 7246-7254 (2003)
PUBMED 12917357
REMARK GeneRIF: Formation of whisker-related principal sensory
nucleus-based lemniscal pathway requires Drg11.
REFERENCE 8 (residues 1 to 263)
AUTHORS Gross MK, Dottori M and Goulding M.
TITLE Lbx1 specifies somatosensory association interneurons in the dorsal
spinal cord
JOURNAL Neuron 34 (4), 535-549 (2002)
PUBMED 12062038
REFERENCE 9 (residues 1 to 263)
AUTHORS Qian Y, Shirasawa S, Chen CL, Cheng L and Ma Q.
TITLE Proper development of relay somatic sensory neurons and D2/D4
interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
JOURNAL Genes Dev 16 (10), 1220-1233 (2002)
PUBMED 12023301
REFERENCE 10 (residues 1 to 263)
AUTHORS Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ,
Basbaum AI and Anderson DJ.
TITLE The paired homeodomain protein DRG11 is required for the projection
of cutaneous sensory afferent fibers to the dorsal spinal cord
JOURNAL Neuron 31 (1), 59-73 (2001)
PUBMED 11498051
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CT009541.12, CJ064638.1 and BQ748034.1.
On Dec 1, 2016 this sequence version replaced XP_006518473.1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: EU670677.1, SRR7345562.1621806.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164136, SAMN01164138
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..263
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="14"
/map="14 19.4 cM"
Protein 1..263
/product="dorsal root ganglia homeobox protein isoform 1"
/note="paired homeodomain protein DRG11; dorsal root
ganglia homeobox protein; paired related homeobox
protein-like 1b; homeobox protein DRG11; dorsal root
ganglion 11"
/calculated_mol_wt=28586
Site order(34..38,40,57,63,76,78..79,82..83,85..87,89..90)
/site_type="DNA binding"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238039"
Site order(36,39,79,82..83,86)
/site_type="other"
/note="specific DNA base contacts [nucleotide binding]"
/db_xref="CDD:238039"
Region 37..89
/region_name="Homeobox"
/note="Homeobox domain; pfam00046"
/db_xref="CDD:425441"
Region 88..146
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q8BYH0.2)"
Region 201..218
/region_name="OAR"
/note="OAR domain; pfam03826"
/db_xref="CDD:427530"
Region 204..217
/region_name="OAR.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
/note="propagated from UniProtKB/Swiss-Prot (Q8BYH0.2)"
Region 220..263
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q8BYH0.2)"
CDS 1..263
/gene="Drgx"
/gene_synonym="Drg11; Prrxl1"
/coded_by="NM_001347590.1:225..1016"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS84110.1"
/db_xref="GeneID:107751"
/db_xref="MGI:MGI:2148204"
ORIGIN
1 mfyfhcppql egtapfgnhs tgdfddgflr rkqrrnrttf tlqqlealea vfaqthypdv
61 ftreelamki nltearvqvw fqnrrakwrk tergasdqep gakepmaevt pppvrninsp
121 ppgdqtrskk ealeaqqslg rtvgptgpff psclpgtlln tatyaqalsh vaslkggplc
181 sccvpdpmgl sflptygcqs nrtasvaalr mkarehseav lqsanllpst ssspgpaskq
241 appegsqdkt sptkeqsege ksv
//
