LOCUS NP_006647 461 aa linear PRI 14-DEC-2022
DEFINITION sialidase-3 isoform a [Homo sapiens].
ACCESSION NP_006647
VERSION NP_006647.3
DBSOURCE REFSEQ: accession NM_006656.6
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 461)
AUTHORS Kirolos SA, Pilling D and Gomer RH.
TITLE The extracellular sialidase NEU3 primes neutrophils
JOURNAL J Leukoc Biol 112 (6), 1399-1411 (2022)
PUBMED 35899930
REMARK GeneRIF: The extracellular sialidase NEU3 primes neutrophils.
REFERENCE 2 (residues 1 to 461)
AUTHORS Miyagi T and Yamamoto K.
TITLE Sialidase NEU3 and its pathological significance
JOURNAL Glycoconj J 39 (5), 677-683 (2022)
PUBMED 35675020
REMARK GeneRIF: Sialidase NEU3 and its pathological significance.
Review article
Erratum:[Glycoconj J. 2022 Aug;39(4):543. PMID: 35834088]
REFERENCE 3 (residues 1 to 461)
AUTHORS Bovio F, Epistolio S, Mozzi A, Monti E, Fusi P, Forcella M and
Frattini M.
TITLE Role of NEU3 Overexpression in the Prediction of Efficacy of
EGFR-Targeted Therapies in Colon Cancer Cell Lines
JOURNAL Int J Mol Sci 21 (22), 8805 (2020)
PUBMED 33233823
REMARK GeneRIF: Role of NEU3 Overexpression in the Prediction of Efficacy
of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 461)
AUTHORS Ghiroldi A, Piccoli M, Creo P, Cirillo F, Rota P, D'Imperio S,
Ciconte G, Monasky MM, Micaglio E, Garatti A, Aureli M, Carsana EV,
Menicanti L, Pappone C and Anastasia L.
TITLE Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts
activation
JOURNAL Biochem J 477 (17), 3401-3415 (2020)
PUBMED 32869836
REMARK GeneRIF: Role of sialidase Neu3 and ganglioside GM3 in cardiac
fibroblasts activation.
REFERENCE 5 (residues 1 to 461)
AUTHORS Chen W, Karhadkar TR, Ryu C, Herzog EL and Gomer RH.
TITLE Reduced Sialylation and Bioactivity of the Antifibrotic Protein
Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary
Fibrosis
JOURNAL Immunohorizons 4 (6), 352-362 (2020)
PUBMED 32576593
REMARK GeneRIF: Reduced Sialylation and Bioactivity of the Antifibrotic
Protein Serum Amyloid P in the Sera of Patients with Idiopathic
Pulmonary Fibrosis.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 461)
AUTHORS Kakugawa Y, Wada T, Yamaguchi K, Yamanami H, Ouchi K, Sato I and
Miyagi T.
TITLE Up-regulation of plasma membrane-associated ganglioside sialidase
(Neu3) in human colon cancer and its involvement in apoptosis
suppression
JOURNAL Proc Natl Acad Sci U S A 99 (16), 10718-10723 (2002)
PUBMED 12149448
REMARK GeneRIF: up-regulation of plasma membrane-associated ganglioside
sialidase (Neu3) in human colon cancer and its involvement in
apoptosis suppression
REFERENCE 7 (residues 1 to 461)
AUTHORS Wang Y, Yamaguchi K, Wada T, Hata K, Zhao X, Fujimoto T and Miyagi
T.
TITLE A close association of the ganglioside-specific sialidase Neu3 with
caveolin in membrane microdomains
JOURNAL J Biol Chem 277 (29), 26252-26259 (2002)
PUBMED 12011038
REMARK GeneRIF: Neu3 functions as a caveolin-related signaling molecule
within caveolin-rich microdomains
REFERENCE 8 (residues 1 to 461)
AUTHORS Wang Y, Yamaguchi K, Shimada Y, Zhao X and Miyagi T.
TITLE Site-directed mutagenesis of human membrane-associated ganglioside
sialidase: identification of amino-acid residues contributing to
substrate specificity
JOURNAL Eur J Biochem 268 (8), 2201-2208 (2001)
PUBMED 11298736
REFERENCE 9 (residues 1 to 461)
AUTHORS Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B,
Croci G, Preti A, Ballabio A, Tettamanti G and Borsani G.
TITLE Identification and expression of NEU3, a novel human sialidase
associated to the plasma membrane
JOURNAL Biochem J 349 (Pt 1), 343-351 (2000)
PUBMED 10861246
REFERENCE 10 (residues 1 to 461)
AUTHORS Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H and Miyagi T.
TITLE Cloning, expression, and chromosomal mapping of a human ganglioside
sialidase
JOURNAL Biochem Biophys Res Commun 261 (1), 21-27 (1999)
PUBMED 10405317
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB240271.1, CN429425.1 and
AP001992.4.
On Nov 1, 2006 this sequence version replaced NP_006647.2.
Summary: This gene product belongs to a family of glycohydrolytic
enzymes which remove sialic acid residues from glycoproteins and
glycolipids. It is localized in the plasma membrane, and its
activity is specific for gangliosides. It may play a role in
modulating the ganglioside content of the lipid bilayer. [provided
by RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes the longest isoform
(a). Variants 1 and 2 both encode the same isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: Y18563.1, ERR279857.766.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000294064.9/ ENSP00000294064.4
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..461
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13.4"
Protein 1..461
/product="sialidase-3 isoform a"
/EC_number="3.2.1.18"
/note="ganglioside sialidase; N-acetyl-alpha-neuraminidase
3; sialidase-3; membrane sialidase; sialidase 3 (membrane
sialidase); ganglioside sialidasedis"
/calculated_mol_wt=51544
Region 44..436
/region_name="Sialidase_non-viral"
/note="Non-viral sialidases; cd15482"
/db_xref="CDD:271234"
Region 57..110
/region_name="Sialidase propeller 1"
/note="Sialidase propeller 1 [structural motif]"
/db_xref="CDD:271234"
Site order(58,84,258,278,373,403,420)
/site_type="active"
/note="catalytic site [active]"
/db_xref="CDD:271234"
Region 119..177
/region_name="Sialidase propeller 2"
/note="Sialidase propeller 2 [structural motif]"
/db_xref="CDD:271234"
Region 191..250
/region_name="Sialidase propeller 3"
/note="Sialidase propeller 3 [structural motif]"
/db_xref="CDD:271234"
Region 257..299
/region_name="Sialidase propeller 4"
/note="Sialidase propeller 4 [structural motif]"
/db_xref="CDD:271234"
Region 311..396
/region_name="Sialidase propeller 5"
/note="Sialidase propeller 5 [structural motif]"
/db_xref="CDD:271234"
Region 402..436
/region_name="Sialidase propeller 6"
/note="Sialidase propeller 6 [structural motif]"
/db_xref="CDD:271234"
CDS 1..461
/gene="NEU3"
/gene_synonym="SIAL3"
/coded_by="NM_006656.6:129..1514"
/note="isoform a is encoded by transcript variant 1"
/db_xref="CCDS:CCDS44682.1"
/db_xref="GeneID:10825"
/db_xref="HGNC:HGNC:7760"
/db_xref="MIM:604617"
ORIGIN
1 mrpadlpprp meespasssa pteteepgss aevmeevttc sfnsplfrqe ddrgityrip
61 allyipptht flafaekrst rrdedalhlv lrrglrigql vqwgplkplm eatlpghrtm
121 npcpvweqks gcvflfficv rghvterqqi vsgrnaarlc fiysqdagcs wsevrdltee
181 vigselkhwa tfavgpghgi qlqsgrlvip aytyyipswf fcfqlpcktr phslmiysdd
241 lgvtwhhgrl irpmvtvece vaevtgragh pvlycsartp nrcraealst dhgegfqrla
301 lsrqlcepph gcqgsvvsfr pleiphrcqd ssskdaptiq qsspgsslrl eeeagtpses
361 wllyshptsr kqrvdlgiyl nqtpleaacw srpwilhcgp cgysdlaale eeglfgclfe
421 cgtkqeceqi afrlfthrei lshlqgdcts pgrnpsqfks n
//
