LOCUS NP_036831 222 aa linear ROD 21-NOV-2023
DEFINITION dnaJ homolog subfamily B member 9 precursor [Rattus norvegicus].
ACCESSION NP_036831
VERSION NP_036831.2
DBSOURCE REFSEQ: accession NM_012699.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 222)
AUTHORS Fritz JM and Weaver TE.
TITLE The BiP cochaperone ERdj4 is required for B cell development and
function
JOURNAL PLoS One 9 (9), e107473 (2014)
PUBMED 25222125
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 222)
AUTHORS Lai CW, Otero JH, Hendershot LM and Snapp E.
TITLE ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family
protein that interacts with ER-associated degradation machinery
JOURNAL J Biol Chem 287 (11), 7969-7978 (2012)
PUBMED 22267725
REFERENCE 3 (residues 1 to 222)
AUTHORS Hageman J, van Waarde MA, Zylicz A, Walerych D and Kampinga HH.
TITLE The diverse members of the mammalian HSP70 machine show distinct
chaperone-like activities
JOURNAL Biochem J 435 (1), 127-142 (2011)
PUBMED 21231916
REFERENCE 4 (residues 1 to 222)
AUTHORS Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
Yates JR.
TITLE Proteomic analysis of human parotid gland exosomes by
multidimensional protein identification technology (MudPIT)
JOURNAL J Proteome Res 8 (3), 1304-1314 (2009)
PUBMED 19199708
REFERENCE 5 (residues 1 to 222)
AUTHORS Dong M, Bridges JP, Apsley K, Xu Y and Weaver TE.
TITLE ERdj4 and ERdj5 are required for endoplasmic reticulum-associated
protein degradation of misfolded surfactant protein C
JOURNAL Mol Biol Cell 19 (6), 2620-2630 (2008)
PUBMED 18400946
REFERENCE 6 (residues 1 to 222)
AUTHORS Berger BJ, Muller TS, Buschmann IR, Peters K, Kirsch M, Christ B
and Prols F.
TITLE High levels of the molecular chaperone Mdg1/ERdj4 reflect the
activation state of endothelial cells
JOURNAL Exp Cell Res 290 (1), 82-92 (2003)
PUBMED 14516790
REFERENCE 7 (residues 1 to 222)
AUTHORS Shen Y, Meunier L and Hendershot LM.
TITLE Identification and characterization of a novel endoplasmic
reticulum (ER) DnaJ homologue, which stimulates ATPase activity of
BiP in vitro and is induced by ER stress
JOURNAL J Biol Chem 277 (18), 15947-15956 (2002)
PUBMED 11836248
REFERENCE 8 (residues 1 to 222)
AUTHORS Prols F, Mayer MP, Renner O, Czarnecki PG, Ast M, Gassler C,
Wilting J, Kurz H and Christ B.
TITLE Upregulation of the cochaperone Mdg1 in endothelial cells is
induced by stress and during in vitro angiogenesis
JOURNAL Exp Cell Res 269 (1), 42-53 (2001)
PUBMED 11525638
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JACYVU010000164.1.
On Oct 10, 2000 this sequence version replaced NP_036831.1.
##Evidence-Data-START##
Transcript exon combination :: X98993.2, BC070915.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760389
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..222
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="6"
/map="6q21"
Protein 1..222
/product="dnaJ homolog subfamily B member 9 precursor"
/note="mdg-1; microvascular endothelial differentiation
gene 1 protein; dnaJ homolog, subfamily b, member 9; DnaJ
(Hsp40) homolog, subfamily B, member 9; ER-resident
protein ERdj4; endoplasmic reticulum DNA J
domain-containing protein 4"
/calculated_mol_wt=23210
sig_peptide 1..23
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2525
mat_peptide 24..222
/product="DnaJ homolog subfamily B member 9.
/id=PRO_0000071034"
/note="propagated from UniProtKB/Swiss-Prot (P97554.2)"
/calculated_mol_wt=23210
Region 27..>134
/region_name="DnaJ_bact"
/note="chaperone protein DnaJ; TIGR02349"
/db_xref="CDD:274090"
Region 91..222
/region_name="Divergent targeting domain.
/evidence=ECO:0000250|UniProtKB:Q9QYI6"
/note="propagated from UniProtKB/Swiss-Prot (P97554.2)"
Site 133
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9UBS3; propagated from
UniProtKB/Swiss-Prot (P97554.2)"
CDS 1..222
/gene="Dnajb9"
/gene_synonym="ERdj4; Mdg1"
/coded_by="NM_012699.3:179..847"
/db_xref="GeneID:24908"
/db_xref="RGD:3070"
ORIGIN
1 matpqsvfvf aicilmitel ilasknyydi lgvpksaser qikkafhkla mkyhpdknks
61 pdaeakfrei aeayetlsda nrrkeydiig hsaftngkgq rsngspfeqs fnfnfddlfk
121 dfnlfgqnqn trskkhfenh fqtrqdgssr qrhhfqefsf ggglfddmfe dmekmfsfsg
181 fdstnrrtvq tenrfhgssk hcrtvtqrrg nmvttytdcs gq
//
