LOCUS NP_415790 865 aa linear CON 09-MAR-2022
DEFINITION DNA topoisomerase 1 [Escherichia coli str. K-12 substr. MG1655].
ACCESSION NP_415790
VERSION NP_415790.1
DBLINK BioProject: PRJNA57779
BioSample: SAMN02604091
DBSOURCE REFSEQ: accession NC_000913.3
KEYWORDS RefSeq.
SOURCE Escherichia coli str. K-12 substr. MG1655
ORGANISM Escherichia coli str. K-12 substr. MG1655
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
REFERENCE 1 (residues 1 to 865)
AUTHORS Riley,M., Abe,T., Arnaud,M.B., Berlyn,M.K., Blattner,F.R.,
Chaudhuri,R.R., Glasner,J.D., Horiuchi,T., Keseler,I.M., Kosuge,T.,
Mori,H., Perna,N.T., Plunkett,G. III, Rudd,K.E., Serres,M.H.,
Thomas,G.H., Thomson,N.R., Wishart,D. and Wanner,B.L.
TITLE Escherichia coli K-12: a cooperatively developed annotation
snapshot--2005
JOURNAL Nucleic Acids Res. 34 (1), 1-9 (2006)
PUBMED 16397293
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 865)
AUTHORS Hayashi,K., Morooka,N., Yamamoto,Y., Fujita,K., Isono,K., Choi,S.,
Ohtsubo,E., Baba,T., Wanner,B.L., Mori,H. and Horiuchi,T.
TITLE Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110
JOURNAL Mol. Syst. Biol. 2, 2006 (2006)
PUBMED 16738553
REFERENCE 3 (residues 1 to 865)
AUTHORS Blattner,F.R., Plunkett,G. III, Bloch,C.A., Perna,N.T., Burland,V.,
Riley,M., Collado-Vides,J., Glasner,J.D., Rode,C.K., Mayhew,G.F.,
Gregor,J., Davis,N.W., Kirkpatrick,H.A., Goeden,M.A., Rose,D.J.,
Mau,B. and Shao,Y.
TITLE The complete genome sequence of Escherichia coli K-12
JOURNAL Science 277 (5331), 1453-1462 (1997)
PUBMED 9278503
REFERENCE 4 (residues 1 to 865)
AUTHORS Arnaud,M., Berlyn,M.K.B., Blattner,F.R., Galperin,M.Y.,
Glasner,J.D., Horiuchi,T., Kosuge,T., Mori,H., Perna,N.T.,
Plunkett,G. III, Riley,M., Rudd,K.E., Serres,M.H., Thomas,G.H. and
Wanner,B.L.
TITLE Workshop on Annotation of Escherichia coli K-12
JOURNAL Unpublished
REMARK Woods Hole, Mass., on 14-18 November 2003 (sequence corrections)
REFERENCE 5 (residues 1 to 865)
AUTHORS Glasner,J.D., Perna,N.T., Plunkett,G. III, Anderson,B.D.,
Bockhorst,J., Hu,J.C., Riley,M., Rudd,K.E. and Serres,M.H.
TITLE ASAP: Escherichia coli K-12 strain MG1655 version m56
JOURNAL Unpublished
REMARK ASAP download 10 June 2004 (annotation updates)
REFERENCE 6 (residues 1 to 865)
AUTHORS Hayashi,K., Morooka,N., Mori,H. and Horiuchi,T.
TITLE A more accurate sequence comparison between genomes of Escherichia
coli K12 W3110 and MG1655 strains
JOURNAL Unpublished
REMARK GenBank accessions AG613214 to AG613378 (sequence corrections)
REFERENCE 7 (residues 1 to 865)
AUTHORS Perna,N.T.
TITLE Escherichia coli K-12 MG1655 yqiK-rfaE intergenic region, genomic
sequence correction
JOURNAL Unpublished
REMARK GenBank accession AY605712 (sequence corrections)
REFERENCE 8 (residues 1 to 865)
AUTHORS Rudd,K.E.
TITLE A manual approach to accurate translation start site annotation: an
E. coli K-12 case study
JOURNAL Unpublished
REFERENCE 9 (residues 1 to 865)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (08-MAR-2022) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 10 (residues 1 to 865)
AUTHORS Blattner,F.R. and Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2014) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REMARK Protein update by submitter
REFERENCE 11 (residues 1 to 865)
AUTHORS Blattner,F.R. and Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2013) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REMARK Protein update by submitter
REFERENCE 12 (residues 1 to 865)
AUTHORS Blattner,F.R. and Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (26-SEP-2013) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REMARK Sequence update by submitter
REFERENCE 13 (residues 1 to 865)
AUTHORS Rudd,K.E.
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2013) Department of Biochemistry and Molecular
Biology, University of Miami Miller School of Medicine, 118 Gautier
Bldg., Miami, FL 33136, USA
REMARK Sequence update by submitter
REFERENCE 14 (residues 1 to 865)
AUTHORS Rudd,K.E.
TITLE Direct Submission
JOURNAL Submitted (24-APR-2007) Department of Biochemistry and Molecular
Biology, University of Miami Miller School of Medicine, 118 Gautier
Bldg., Miami, FL 33136, USA
REMARK Annotation update from ecogene.org as a multi-database
collaboration
REFERENCE 15 (residues 1 to 865)
AUTHORS Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (07-FEB-2006) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REMARK Protein updates by submitter
REFERENCE 16 (residues 1 to 865)
AUTHORS Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (10-JUN-2004) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REMARK Sequence update by submitter
REFERENCE 17 (residues 1 to 865)
AUTHORS Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (13-OCT-1998) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REFERENCE 18 (residues 1 to 865)
AUTHORS Blattner,F.R. and Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (02-SEP-1997) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
REFERENCE 19 (residues 1 to 865)
AUTHORS Blattner,F.R. and Plunkett,G. III.
TITLE Direct Submission
JOURNAL Submitted (16-JAN-1997) Laboratory of Genetics, University of
Wisconsin, 425G Henry Mall, Madison, WI 53706-1580, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to AAC74356.
Changes to proteins and annotation made on March 7, 2022. Current
U00096 annotation updates are derived from EcoCyc
https://ecocyc.org/. Suggestions for updates can be sent to
biocyc-support@ai.sri.com. These updates are being generated from a
collaboration that includes EcoCyc, the University of Wisconsin,
UniProtKB/Swiss-Prot, and the National Center for Biotechnology
Information (NCBI).
COMPLETENESS: full length.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..865
/organism="Escherichia coli str. K-12 substr. MG1655"
/strain="K-12"
/sub_strain="MG1655"
/db_xref="taxon:511145"
Protein 1..865
/product="DNA topoisomerase 1"
/EC_number="5.6.2.1"
/calculated_mol_wt=97219
Region 2..849
/region_name="PRK07561"
/note="DNA topoisomerase I subunit omega; Validated"
/db_xref="CDD:236048"
CDS 1..865
/gene="topA"
/locus_tag="b1274"
/gene_synonym="ECK1268; supX"
/coded_by="NC_000913.3:1331048..1333645"
/transl_table=11
/db_xref="UniProtKB/Swiss-Prot:P06612"
/db_xref="ASAP:ABE-0004275"
/db_xref="ECOCYC:EG11013"
/db_xref="GeneID:945862"
CONTIG join(WP_001297122.1:1..865)
ORIGIN
1 mgkalvives pakaktinky lgsdyvvkss vghirdlpts gsaakksads tstktakkpk
61 kdergalvnr mgvdpwhnwe ahyevlpgke kvvselkqla ekadhiylat dldregeaia
121 whlreviggd darysrvvfn eitknairqa fnkpgelnid rvnaqqarrf mdrvvgymvs
181 pllwkkiarg lsagrvqsva vrlvverere ikafvpeefw evdastttps gealalqvth
241 qndkpfrpvn keqtqaavsl lekarysvle redkpttskp gapfitstlq qaastrlgfg
301 vkktmmmaqr lyeagyitym rtdstnlsqd avnmvrgyis dnfgkkylpe spnqyasken
361 sqeaheairp sdvnvmaesl kdmeadaqkl yqliwrqfva cqmtpakyds ttltvgagdf
421 rlkargrilr fdgwtkvmpa lrkgdedril pavnkgdalt lveltpaqhf tkpparfsea
481 slvkelekrg igrpstyasi istiqdrgyv rvenrrfyae kmgeivtdrl eenfrelmny
541 dftaqmensl dqvanheaew kavldhffsd ftqqldkaek dpeeggmrpn qmvltsidcp
601 tcgrkmgirt astgvflgcs gyalppkerc kttinlvpen evlnvleged aetnalrakr
661 rcpkcgtamd sylidpkrkl hvcgnnptcd gyeieegefr ikgydgpive cekcgsemhl
721 kmgrfgkyma ctneeckntr kilrngevap pkedpvplpe lpceksdayf vlrdgaagvf
781 laantfpksr etraplveel yrfrdrlpek lryladapqq dpegnktmvr fsrktkqqyv
841 ssekdgkatg wsafyvdgkw vegkk
//