LOCUS       XP_005252204             635 aa            linear   PRI 05-OCT-2023
DEFINITION  tyrosine-protein kinase SYK isoform X1 [Homo sapiens].
ACCESSION   XP_005252204
VERSION     XP_005252204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005252147.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     Protein         1..635
                     /product="tyrosine-protein kinase SYK isoform X1"
                     /calculated_mol_wt=71935
     Region          13..116
                     /region_name="SH2_N-SH2_Zap70_Syk_like"
                     /note="N-terminal Src homology 2 (SH2) domain found in
                     Zeta-chain-associated protein kinase 70 (ZAP-70) and
                     Spleen tyrosine kinase (Syk) proteins; cd09938"
                     /db_xref="CDD:198191"
     Site            order(22,42,63,65)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198191"
     Site            order(64,76..77,79,98..99)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198191"
     Region          164..262
                     /region_name="SH2_C-SH2_Syk_like"
                     /note="C-terminal Src homology 2 (SH2) domain found in
                     Spleen tyrosine kinase (Syk) proteins; cd10401"
                     /db_xref="CDD:198264"
     Site            order(175,195,197,215,217)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198264"
     Site            order(216,228,231,250)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198264"
     Region          375..631
                     /region_name="PTKc_Syk"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Spleen tyrosine kinase; cd05116"
                     /db_xref="CDD:133247"
     Site            order(377..379,382,385,400,402,420,433,448..452,454..455,
                     494,498..499,501,511..512,531..535,544,578)
                     /site_type="active"
                     /db_xref="CDD:133247"
     Site            order(377..379,382,385,400,402,420,433,448..452,454..455,
                     498..499,501,511..512)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:133247"
     Site            order(494,498,531..535,544,578)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:133247"
     Site            511..537
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:133247"
     CDS             1..635
                     /gene="SYK"
                     /gene_synonym="IMD82; p72-Syk"
                     /coded_by="XM_005252147.5:263..2170"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:HGNC:11491"
                     /db_xref="MIM:600085"
ORIGIN      
        1 massgmadsa nhlpfffgni treeaedylv qggmsdglyl lrqsrnylgg falsvahgrk
       61 ahhytierel ngtyaiaggr thaspadlch yhsqesdglv cllkkpfnrp qgvqpktgpf
      121 edlkenlire yvkqtwnlqg qaleqaiisq kpqlekliat tahekmpwfh gkisreeseq
      181 ivligsktng kflirardnn gsyalcllhe gkvlhyridk dktgklsipe gkkfdtlwql
      241 vehysykadg llrvltvpcq kigtqgnvnf ggrpqlpgsh patwsaggii sriksysfpk
      301 pghrksspaq gnrqestvsf npyepelapw aadkgpqrea lpmdtevyes pyadpeeirp
      361 kevyldrkll tledkelgsg nfgtvkkgyy qmkkvvktva vkilkneand palkdellae
      421 anvmqqldnp yivrmigice aeswmlvmem aelgplnkyl qqnrhvkdkn iielvhqvsm
      481 gmkyleesnf vhrdlaarnv llvtqhyaki sdfglskalr adenyykaqt hgkwpvkwya
      541 pecinyykfs sksdvwsfgv lmweafsygq kpyrgmkgse vtamlekger mgcpagcpre
      601 mydlmnlcwt ydvenrpgfa avelrlrnyy ydvvn
//