LOCUS YP_001461509 389 aa linear CON 16-DEC-2014
DEFINITION methylcitrate synthase [Escherichia coli E24377A].
ACCESSION YP_001461509
VERSION YP_001461509.1 GI:157157579
DBLINK BioProject: PRJNA58395
DBSOURCE REFSEQ: accession NC_009801.1
KEYWORDS RefSeq.
SOURCE Escherichia coli E24377A
ORGANISM Escherichia coli E24377A
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
Enterobacteriaceae; Escherichia.
REFERENCE 1 (residues 1 to 389)
AUTHORS Rasko,D.A., Rosovitz,M.J., Myers,G.S., Mongodin,E.F., Fricke,W.F.,
Gajer,P., Crabtree,J., Sebaihia,M., Thomson,N.R., Chaudhuri,R.,
Henderson,I.R., Sperandio,V. and Ravel,J.
TITLE The pangenome structure of Escherichia coli: comparative genomic
analysis of E. coli commensal and pathogenic isolates
JOURNAL J. Bacteriol. 190 (20), 6881-6893 (2008)
PUBMED 18676672
REFERENCE 2 (residues 1 to 389)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (13-SEP-2007) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (residues 1 to 389)
AUTHORS Rasko,D.A., Rosovitz,M.J., Brinkley,C., Myers,G.S.A., Seshadri,R.,
Cer,R.Z., Jiang,L. and Ravel,J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) The Institute for Genomic Research, 9712
Medical Center Dr., Rockville, MD 20850, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from ABV19317.
Source DNA and bacteria available from Jacques Ravel
(jravel@tigr.org).
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..389
/organism="Escherichia coli E24377A"
/strain="E24377A"
/db_xref="taxon:331111"
Protein 1..389
/product="methylcitrate synthase"
/EC_number="2.3.3.5"
/calculated_mol_wt=43003
Region 10..388
/region_name="GltA"
/note="Citrate synthase [Energy production and
conversion]; COG0372"
/db_xref="CDD:223449"
Region 20..385
/region_name="Ec2MCS_like_1"
/note="Subgroup of Escherichia coli (Ec) 2-methylcitrate
synthase (2MCS)_like. 2MCS catalyzes the condensation of
propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form
2-methylcitrate and coenzyme A (CoA) during propionate
metabolism. Citrate synthase (CS)...; cd06117"
/db_xref="CDD:99870"
Site order(20..22,25..29,91..92,95..96,104,108,112,115,163,
200..204,207..208,212,215..218,221,228..229,231..234,275,
366..376)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:99870"
Site order(23,200,203,234..236,238,241,268..275,278,283,318,
320,323,325,346,350,366,369)
/site_type="active"
/db_xref="CDD:99870"
Site order(23,200,203,234..235,268..269,271..275,283,323,350)
/site_type="other"
/note="citrylCoA binding site [chemical binding]"
/db_xref="CDD:99870"
Site order(200,203,235..236,274,283,325,346,350,369)
/site_type="other"
/note="oxalacetate/citrate binding site [chemical
binding]"
/db_xref="CDD:99870"
Site order(234..235,238,241,268..273,275,278,318,320,323,325,
366)
/site_type="other"
/note="coenzyme A binding site [chemical binding]"
/db_xref="CDD:99870"
Site order(235,274,325)
/site_type="active"
/note="catalytic triad [active]"
/db_xref="CDD:99870"
CDS 1..389
/gene="prpC"
/locus_tag="EcE24377A_0357"
/coded_by="NC_009801.1:385696..386865"
/note="catalyzes the synthesis of 2-methylcitrate from
propionyl-CoA and oxaloacetate; also catalyzes the
condensation of oxaloacetate with acetyl-CoA but with a
lower specificity"
/transl_table=11
/db_xref="GeneID:5589480"
CONTIG join(WP_001285909.1:1..389)
ORIGIN
1 msdttilqns thvikpkksv alsgvpagnt alctvgksgn dlhyrgydil dlaehcefee
61 vahllihgkl ptrdelaayk tklkalrglp anvrtvleal paashpmdvm rtgvsalgct
121 lpekeghtvs gardiadkll aslssillyw yhyshngeri qpetdddsig ghflhllhge
181 kpsqswekam hislvlyaeh efnastftsr viagtgsdmy saiigaigal rgpkhggane
241 vsleiqqrye tpdeaeadir krvenkevvi gfghpvytia dprhqvikrv akqlsqeggs
301 lkmyniadrl etvmweskkm fpnldwfsav synmmgvpte mftplfviar vtgwaahiie
361 qrqdnkiirp sanyvgpedr qfvaldkrq
//
