KEGG   REACTION: R00014Help
Entry
R00014                      Reaction                               

Name
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Definition
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
RPair
C00068_C05125 main [RC:RC00027]
C00022_C05125 main [RC:RC02744]
C00011_C00022 leave
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pyruvate metabolism
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00161  
pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  
pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  
pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  
pyruvate decarboxylase [EC:4.1.1.1]
K01652  
acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  
acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  
acetolactate synthase II small subunit [EC:2.2.1.6]

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