KEGG   REACTION: R00111
Entry
R00111                      Reaction                               
Name
N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Definition
NADPH + 2 N(omega)-Hydroxyarginine + 2 Oxygen + H+ <=> NADP+ + 2 Nitric oxide + 2 L-Citrulline + 2 H2O
Equation
C00005 + 2 C05933 + 2 C00007 + C00080 <=> C00006 + 2 C00533 + 2 C00327 + 2 C00001
Comment
the latter part of multi-step reaction (see R00557, R00558+R00111)
following after R00558
NADH (see R10108)
Reaction class
RC00001  C00005_C00006
RC01044  C00327_C05933
RC02757  C00533_C05933
Enzyme
1.14.13.39
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39
     R00111  NADPH + 2 N(omega)-Hydroxyarginine + 2 Oxygen + H+ <=> NADP+ + 2 Nitric oxide + 2 L-Citrulline + 2 H2O
Orthology
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
Other DBs
RHEA: 24667

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (1507)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (1503)   
All databases (1524)   

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