KEGG   REACTION: R00557Help
Entry
R00557                      Reaction                               

Name
L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Definition
2 L-Arginine + 4 Oxygen + 3 NADPH + 3 H+ <=> 2 Nitric oxide + 2 L-Citrulline + 3 NADP+ + 4 H2O
Equation
2 C00062 + 4 C00007 + 3 C00005 + 3 C00080 <=> 2 C00533 + 2 C00327 + 3 C00006 + 4 C00001
Comment
multi-step reaction (see R00558+R00111)
NADH (see R10106)
RPair
C00005_C00006 cofac
C00001_C00007 leave
C00062_C00327 main
C00007_C00327 leave
C00007_C00533 leave
C00062_C00533 leave
Enzyme
Pathway
Arginine and proline metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00491  
nitric-oxide synthase, bacterial [EC:1.14.13.39]
K13240  
nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  
nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  
nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13253  
nitric-oxide synthase, invertebrate [EC:1.14.13.39]
K13427  
nitric-oxide synthase, plant [EC:1.14.13.39]

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