KEGG   REACTION: R00575
Entry
R00575                      Reaction                               
Name
HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
Definition
2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate
Equation
2 C00002 + C00064 + C00288 + C00001 <=> 2 C00008 + C00009 + C00025 + C00169
Comment
multi-step reaction (see R00256+R10948+R10949+R01395)
Reaction class
RC00002  C00002_C00008
RC00010  C00025_C00064
RC02750  C00064_C00169
Enzyme
6.3.5.5
Pathway
rn00240  Pyrimidine metabolism
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5
     R00575  2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate
Orthology
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 18636

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
Gene (19289)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (19284)   
All databases (19312)   

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