KEGG   REACTION: R01074
Entry
R01074                      Reaction                               
Name
biotin:CoA ligase (AMP-forming);
biotin:apo-[carboxylase] ligase (AMP-forming);
ATP:biotin adenylyltransferase
Definition
ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
Equation
C00002 + C00120 <=> C00013 + C05921
Comment
first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604)
subsequently R05145 or R03762
Reaction class
RC00043  C00120_C05921
Enzyme
6.2.1.11        6.3.4.9         6.3.4.10        6.3.4.11        
6.3.4.15
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.11
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.9
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.10
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.11
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.15
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
Orthology
K01942  biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]
K01947  biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33]
K03524  BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
Other DBs
RHEA: 31118

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (6)   
   KEGG ENZYME (5)   
   KEGG RCLASS (1)   
Gene (9474)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (9471)   
All databases (9489)   

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KEGG   REACTION: R03762
Entry
R03762                      Reaction                               
Name
biotin:CoA ligase (AMP-forming);
biotinyl-5'-AMP:CoA biotinyltransferase
Definition
Biotinyl-5'-AMP + CoA <=> AMP + Biotinyl-CoA
Equation
C05921 + C00010 <=> C00020 + C01894
Comment
second step of two-step reaction (R01075, R01074+R03762)
followng after R01074
Reaction class
RC00004  C00010_C01894
RC00070  C00020_C05921
RC02816  C01894_C05921
Enzyme
6.2.1.11
Pathway
rn00780  Biotin metabolism
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.11
     R03762  Biotinyl-5'-AMP + CoA <=> AMP + Biotinyl-CoA

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
All databases (11)   

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