KEGG   REACTION: R01978Help
Entry
R01978                      Reaction                               

Name
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Equation
Comment
possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
Reactant pair
C00010_C00024 main [RC:RC00004]
C00332_C00356 main [RC:RC00503]
C00024_C00356 trans
C00001_C00356 leave
Enzyme
Pathway
Synthesis and degradation of ketone bodies
Valine, leucine and isoleucine degradation
Butanoate metabolism
Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Module
M00088  
Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  
C5 isoprenoid biosynthesis, mevalonate pathway
Orthology
K01641  
hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]

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