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| Definition |
Estrone + H+ + Oxygen + NADPH <=> 16alpha-Hydroxyestrone + NADP+ + H2O
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| Equation |
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| Reaction class |
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| Enzyme |
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| Pathway |
| rn00140 | Steroid hormone biosynthesis |
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| Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.1
R02356 Estrone + H+ + Oxygen + NADPH <=> 16alpha-Hydroxyestrone + NADP+ + H2O
1.14.14.-
R02356 Estrone + H+ + Oxygen + NADPH <=> 16alpha-Hydroxyestrone + NADP+ + H2O
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
1.14.14.1
R04122 Alkane <=> ROH
R02356 Estrone <=> 16alpha-Hydroxyestrone
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| Orthology |
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| Reference |
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| Authors |
Lee AJ, Mills LH, Kosh JW, Conney AH, Zhu BT. |
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| Title |
NADPH-dependent metabolism of estrone by human liver microsomes. |
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| Journal |
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| Reference |
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| Authors |
Huang Z, Guengerich FP, Kaminsky LS. |
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| Title |
16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. |
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| Journal |
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