KEGG   REACTION: R03194Help
Entry
R03194                      Reaction                               

Name
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Definition
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Equation
2 C00019 + C01051 <=> 2 C00021 + C02463
Comment
multifunctional enzyme: siroheme synthase: uroporphyrinogen III methyltransferase (R03194+R03947+R02864)
subsequently R03947
two-step reaction (R07237+R07238)
RPair
C00019_C00021 main [RC:RC00003]
C01051_C02463 main [RC:RC00871]
C00019_C02463 trans
C00019_C02463 trans
Enzyme
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00121  
Heme biosynthesis, glutamate => protoheme/siroheme
Orthology
K00589  
uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02302  
uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02303  
uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02496  
uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K13542  
uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
K13543  
uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]

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