KEGG   REACTION: R03444Help
Entry
R03444                      Reaction                               

Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
Comment
first step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00498  C01251_C04002
Enzyme
4.2.1.114       4.2.1.-
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K17450  homoaconitase [EC:4.2.1.-]
Other DBs
RHEA: 26104

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