KEGG   REACTION: R03444Help
Entry
R03444                      Reaction                               

Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
Comment
first step of two-step reaction (see R09720, R03444+R04371)
RPair
C01251_C04002 main [RC:RC00498]
C00001_C01251 leave
Enzyme
4.2.1.114       4.2.1.-
Pathway
Lysine biosynthesis
Metabolic pathways
Microbial metabolism in diverse environments
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
Module
M00030  
Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  
Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  
2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K16792  
methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  
methanogen homoaconitase small subunit [EC:4.2.1.114]
K17450  
homoaconitase [EC:4.2.1.-]

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