KEGG   REACTION: R04867
Entry
R04867                      Reaction                               
Name
S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase
Definition
S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
Equation
Reaction class
RC00003  C00019_C00021
RC00496  C05545_C05546
Enzyme
2.1.1.59        2.1.1.60        2.1.1.354       2.1.1.355       
2.1.1.356       2.1.1.359       2.1.1.360       2.1.1.366       
2.1.1.372
Pathway
rn00310  Lysine degradation
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.59
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.60
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.354
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.355
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.356
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.359
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.360
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.366
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
    2.1.1.372
     R04867  S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
Orthology
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11421  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
K11423  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K11424  [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]
K11425  [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355]
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
K15588  [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355]
K18804  [cytochrome c]-lysine N-methyltransferase [EC:2.1.1.59]
K18826  calmodulin-lysine N-methyltransferase [EC:2.1.1.60]
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3 [EC:2.1.1.354]
K23700  [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]
K24407  [histone H4]-lysine20 N-trimethyltransferase [EC:2.1.1.372]
Other DBs
RHEA: 54203

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