KEGG   REACTION: R05467Help
Entry
R05467                      Reaction                               

Name
L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)
Definition
L-N2-(2-Carboxyethyl)arginine + ATP <=> Deoxyguanidinoproclavaminic acid + AMP + Diphosphate
Equation
Comment
beta-lactam synthase
RPair
C00002_C00020 ligase
C00002_C00013 ligase
C06655_C06656 main [RC:RC01389]
Enzyme
Pathway
Clavulanic acid biosynthesis
Biosynthesis of secondary metabolites
Module
M00674  
Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Orthology
K12674  
(carboxyethyl)arginine beta-lactam-synthase [EC:6.3.3.4]
Reference
1  [PMID:9614345]
McGowan SJ, Bycroft BW, Salmond GP.
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
Trends. Microbiol. 6 (1998) 203-8.

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