KEGG   REACTION: R05468
Entry
R05468                      Reaction                               
Name
proclavaminate,2-oxoglutarate:oxygen oxidoreductase (cyclyzing)
Definition
Proclavaminic acid + Oxygen + 2-Oxoglutarate <=> Dihydroclavaminic acid + CO2 + Succinate + H2O
Equation
C06658 + C00007 + C00026 <=> C06659 + C00011 + C00042 + C00001
Comment
see R05466, R05469
Reaction class
RC01390  C06658_C06659
Enzyme
1.14.11.21
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.21
     R05468  Proclavaminic acid + Oxygen + 2-Oxoglutarate <=> Dihydroclavaminic acid + CO2 + Succinate + H2O
Orthology
K12675  clavaminate synthase [EC:1.14.11.21]
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Other DBs
RHEA: 12776 19788

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (16)   
All databases (34)   

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