KEGG   REACTION: R08266
Entry
R08266                      Reaction                               
Name
tamoxifen,NADPH:oxygen oxidoreductase (N-oxide-forming)
Definition
Tamoxifen + Oxygen + NADPH + H+ <=> Tamoxifen N-oxide + NADP+ + H2O
Equation
C07108 + C00007 + C00005 + C00080 <=> C16545 + C00006 + C00001
Comment
FMO1,FMO3
Reaction class
RC00001  C00005_C00006
RC02233  C07108_C16545
Enzyme
1.14.13.8
Pathway
rn00982  Drug metabolism - cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.8
     R08266  Tamoxifen + Oxygen + NADPH + H+ <=> Tamoxifen N-oxide + NADP+ + H2O
Orthology
K00485  dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (3557)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (3556)   
All databases (3570)   

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