KEGG   REACTION: R08392Help
Entry
R08392                      Reaction                               

Definition
Retinoate + NADPH + H+ + Oxygen <=> all-trans-4-Hydroxyretinoic acid + NADP+ + H2O
Equation
Comment
CYP1A1/2, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP2S1
RPair
C00005_C00006 cofac [RC:RC00001]
C00001_C00007 cofac
C00007_C16677 leave
C00777_C16677 main [RC:RC00723]
Enzyme
1.14.13.-       1.14.14.1
Pathway
Retinol metabolism
Orthology
K07408  
cytochrome P450, family 1, subfamily A, polypeptide 1 [EC:1.14.14.1]
K07409  
cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
K07411  
cytochrome P450, family 2, subfamily A [EC:1.14.14.1]
K07412  
cytochrome P450, family 2, subfamily B [EC:1.14.14.1]
K07413  
cytochrome P450, family 2, subfamily C [EC:1.14.14.1]
K07420  
cytochrome P450, family 2, subfamily S, polypeptide 1 [EC:1.14.14.1]
K07424  
cytochrome P450, family 3, subfamily A [EC:1.14.14.1]
K07437  
cytochrome P450, family 26, subfamily A
K12664  
cytochrome P450, family 26, subfamily B
K12665  
cytochrome P450, family 26, subfamily C
K17683  
cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
K17689  
cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
K17690  
cytochrome P450, family 3, subfamily A, polypeptide 5 [EC:1.14.14.1]
K17691  
cytochrome P450, family 3, subfamily A, polypeptide 7 [EC:1.14.14.1]
K17709  
cytochrome P450, family 2, subfamily B, polypeptide 6 [EC:1.14.13.-]
K17718  
cytochrome P450, family 2, subfamily C, polypeptide 8 [EC:1.14.14.1]
K17719  
cytochrome P450, family 2, subfamily C, polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
K17720  
cytochrome P450, family 2, subfamily C, polypeptide 18 [EC:1.14.14.1]

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