KEGG   REACTION: R08392
Entry
R08392                      Reaction                               
Definition
Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00777 + C03024 + C00007 <=> C16677 + C03161 + C00001
Comment
CYP1A1/2, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP2S1
Reaction class
RC00723  C00777_C16677
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08392  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.-
     R08392  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K07423  cytochrome P450 family 2 subfamily W1 [EC:1.14.14.-]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07437  cytochrome P450 family 26 subfamily A [EC:1.14.14.-]
K12664  cytochrome P450 family 26 subfamily B [EC:1.14.14.-]
K12665  cytochrome P450 family 26 subfamily C [EC:1.14.14.-]
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17691  cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (5736)   
   KEGG ORTHOLOGY (19)   
   KEGG GENES (5717)   
All databases (5749)   

Download RDF
DBGET integrated database retrieval system