KEGG   REACTION: R11125
Entry
R11125                      Reaction                               
Name
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid forming)
Definition
Acetyl-CoA + 5 Malonyl-CoA + 2 NADPH + 2 H+ <=> 2-Hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
Equation
C00024 + 5 C00083 + 2 C00005 + 2 C00080 <=> C20856 + 6 C00010 + 5 C00011 + 3 C00001 + 2 C00006
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00024  C00010_C00083
Enzyme
2.3.1.237
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.237
     R11125  Acetyl-CoA + 5 Malonyl-CoA + 2 NADPH + 2 H+ <=> 2-Hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
Orthology
K20422  neocarzinostatin naphthoate synthase [EC:2.3.1.237]
Other DBs
RHEA: 42843

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (9)   
All databases (30)   

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