KEGG   Rattus norvegicus (rat): 116554Help
Entry
116554            CDS       T01003                                 

Gene name
Mapk8, JNK
Definition
mitogen-activated protein kinase 8 (EC:2.7.11.24)
Orthology
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
FoxO signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    116554 (Mapk8)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    116554 (Mapk8)
   04010 MAPK signaling pathway
    116554 (Mapk8)
   04012 ErbB signaling pathway
    116554 (Mapk8)
   04310 Wnt signaling pathway
    116554 (Mapk8)
   04668 TNF signaling pathway
    116554 (Mapk8)
   04068 FoxO signaling pathway
    116554 (Mapk8)
 Cellular Processes
  Cell communication
   04510 Focal adhesion
    116554 (Mapk8)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    116554 (Mapk8)
   04621 NOD-like receptor signaling pathway
    116554 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    116554 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    116554 (Mapk8)
  Endocrine system
   04910 Insulin signaling pathway
    116554 (Mapk8)
   04920 Adipocytokine signaling pathway
    116554 (Mapk8)
   04912 GnRH signaling pathway
    116554 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    116554 (Mapk8)
   04917 Prolactin signaling pathway
    116554 (Mapk8)
  Nervous system
   04728 Dopaminergic synapse
    116554 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    116554 (Mapk8)
   04722 Neurotrophin signaling pathway
    116554 (Mapk8)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    116554 (Mapk8)
  Development
   04380 Osteoclast differentiation
    116554 (Mapk8)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    116554 (Mapk8)
   05210 Colorectal cancer
    116554 (Mapk8)
   05212 Pancreatic cancer
    116554 (Mapk8)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    116554 (Mapk8)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    116554 (Mapk8)
  Infectious diseases
   05132 Salmonella infection
    116554 (Mapk8)
   05133 Pertussis
    116554 (Mapk8)
   05152 Tuberculosis
    116554 (Mapk8)
   05166 HTLV-I infection
    116554 (Mapk8)
   05164 Influenza A
    116554 (Mapk8)
   05161 Hepatitis B
    116554 (Mapk8)
   05160 Hepatitis C
    116554 (Mapk8)
   05168 Herpes simplex infection
    116554 (Mapk8)
   05169 Epstein-Barr virus infection
    116554 (Mapk8)
   05145 Toxoplasmosis
    116554 (Mapk8)
   05142 Chagas disease (American trypanosomiasis)
    116554 (Mapk8)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     116554 (Mapk8)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [Table]
   116554 (Mapk8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
UniProt: 
Position
16p16
AA seq 427 aa AA seqDB search
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSPSVNDMSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt NT seq  +upstreamnt  +downstreamnt
atgagcagaagtaaacgtgacaacaatttttatagtgtagagatcggagattctacattc
acagtcctaaaacgataccagaacttaaagcctataggctcaggagctcaaggaatagtg
tgtgcagcttatgatgctattcttgaaagaaatgttgcaatcaagaagctcagccggcca
tttcagaatcagacccatgctaagcgagcctaccgagaactagttcttatgaagtgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagttagatcatgaaagaatgtcctaccttctctatcaaatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcctagtaatatagtagtcaaa
tcagactgcactttgaagattcttgattttggactggcaaggactgcaggaacgagtttt
atgatgacgccttacgtggtaactcgttactacagagcaccagaggtcattctcggcatg
ggctacaaggagaacgtggatttatggtctgtggggtgcattatgggagaaatggtttgc
ctcaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
ctcggaacaccttgtcctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaagtacgctggctatagctttgagaaactgtttcctgatgtgcttttc
ccagctgactcagaacataacaaacttaaagccagtcaggcgagagatttgttatctaaa
atgctggtgatagatgcgtccaaaaggatctccgtagacgaagctctccagcacccgtac
atcaacgtctggtatgatccttcagaagcagaggccccaccaccaaagatccctgacaag
cagttagatgaaagggagcacacaatagaggagtggaaagaactgatatacaaggaggtc
atggatttggaggagcgaactaagaatggcgtcataagagggcagccgtctcctttaggt
gcagcagtgatcaatggctctcagcatccgtcgtcttcgccgtctgtcaatgacatgtct
tcaatgtccacagatccgactctggcctcggatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

DBGET integrated database retrieval system