KEGG   Rattus norvegicus (rat): 170851Help
Entry
170851            CDS       T01003                                 

Gene name
Map2k1, Mek1
Definition
(RefSeq) mitogen activated protein kinase kinase 1
  KO
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Vascular smooth muscle contraction
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    170851 (Map2k1)
   04015 Rap1 signaling pathway
    170851 (Map2k1)
   04010 MAPK signaling pathway
    170851 (Map2k1)
   04012 ErbB signaling pathway
    170851 (Map2k1)
   04370 VEGF signaling pathway
    170851 (Map2k1)
   04371 Apelin signaling pathway
    170851 (Map2k1)
   04668 TNF signaling pathway
    170851 (Map2k1)
   04066 HIF-1 signaling pathway
    170851 (Map2k1)
   04068 FoxO signaling pathway
    170851 (Map2k1)
   04072 Phospholipase D signaling pathway
    170851 (Map2k1)
   04071 Sphingolipid signaling pathway
    170851 (Map2k1)
   04024 cAMP signaling pathway
    170851 (Map2k1)
   04022 cGMP - PKG signaling pathway
    170851 (Map2k1)
   04151 PI3K-Akt signaling pathway
    170851 (Map2k1)
   04150 mTOR signaling pathway
    170851 (Map2k1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    170851 (Map2k1)
  Cell growth and death
   04114 Oocyte meiosis
    170851 (Map2k1)
   04210 Apoptosis
    170851 (Map2k1)
   04218 Cellular senescence
    170851 (Map2k1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    170851 (Map2k1)
   04540 Gap junction
    170851 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    170851 (Map2k1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    170851 (Map2k1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    170851 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    170851 (Map2k1)
   04660 T cell receptor signaling pathway
    170851 (Map2k1)
   04662 B cell receptor signaling pathway
    170851 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    170851 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    170851 (Map2k1)
   04062 Chemokine signaling pathway
    170851 (Map2k1)
  Endocrine system
   04910 Insulin signaling pathway
    170851 (Map2k1)
   04912 GnRH signaling pathway
    170851 (Map2k1)
   04915 Estrogen signaling pathway
    170851 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    170851 (Map2k1)
   04917 Prolactin signaling pathway
    170851 (Map2k1)
   04921 Oxytocin signaling pathway
    170851 (Map2k1)
   04926 Relaxin signaling pathway
    170851 (Map2k1)
   04919 Thyroid hormone signaling pathway
    170851 (Map2k1)
   04916 Melanogenesis
    170851 (Map2k1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    170851 (Map2k1)
  Nervous system
   04725 Cholinergic synapse
    170851 (Map2k1)
   04726 Serotonergic synapse
    170851 (Map2k1)
   04720 Long-term potentiation
    170851 (Map2k1)
   04730 Long-term depression
    170851 (Map2k1)
   04722 Neurotrophin signaling pathway
    170851 (Map2k1)
  Development
   04380 Osteoclast differentiation
    170851 (Map2k1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    170851 (Map2k1)
   05230 Central carbon metabolism in cancer
    170851 (Map2k1)
   05231 Choline metabolism in cancer
    170851 (Map2k1)
   05206 MicroRNAs in cancer
    170851 (Map2k1)
   05205 Proteoglycans in cancer
    170851 (Map2k1)
   05210 Colorectal cancer
    170851 (Map2k1)
   05212 Pancreatic cancer
    170851 (Map2k1)
   05225 Hepatocellular carcinoma
    170851 (Map2k1)
   05214 Glioma
    170851 (Map2k1)
   05216 Thyroid cancer
    170851 (Map2k1)
   05221 Acute myeloid leukemia
    170851 (Map2k1)
   05220 Chronic myeloid leukemia
    170851 (Map2k1)
   05218 Melanoma
    170851 (Map2k1)
   05211 Renal cell carcinoma
    170851 (Map2k1)
   05219 Bladder cancer
    170851 (Map2k1)
   05215 Prostate cancer
    170851 (Map2k1)
   05213 Endometrial cancer
    170851 (Map2k1)
   05224 Breast cancer
    170851 (Map2k1)
   05223 Non-small cell lung cancer
    170851 (Map2k1)
  Neurodegenerative diseases
   05020 Prion diseases
    170851 (Map2k1)
  Substance dependence
   05034 Alcoholism
    170851 (Map2k1)
  Infectious diseases
   05164 Influenza A
    170851 (Map2k1)
   05161 Hepatitis B
    170851 (Map2k1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    170851 (Map2k1)
   05165 Human papillomavirus infection
    170851 (Map2k1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    170851 (Map2k1)
   01522 Endocrine resistance
    170851 (Map2k1)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     170851 (Map2k1)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   170851 (Map2k1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
RGD: 
Ensembl: 
UniProt: 
Position
8q24
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctccgcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagctggacgagcagcagcggaagcgccttgaggcctttctgacgcagaagcagaaggtg
ggagagttgaaggatgatgactttgagaagatcagtgaactgggggctggcaatggtgga
gtggtgttcaaggtctcccacaagccatctggcctggttatggctaggaagctaattcac
ctggagatcaaacccgcaatccggaaccagatcatccgggagctgcaggtgctgcatgag
tgcaactccccgtacatagtgggcttctacggggccttctacagtgacggcgagatcagc
atctgcatggagcacatggatggtgggtccttggatcaagtgctgaagaaagctggaaga
attcctgagcaaattttaggaaaagtcagcatcgctgtgataaaaggcctgacatatcta
cgagagaagcacaagattatgcacagagatgtcaagccttccaacattctagtgaactca
cgtggggagatcaaactctgcgattttggggtcagcgggcagctaattgactccatggcc
aactccttcgtgggaacaaggtcctacatgtcgcctgagagactccaggggactcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttggaaga
taccccattcctcctcctgatgccaaggagctggagctgctgtttggatgccaggtggaa
ggagacgcggccgaaacgccacccaggccaaggacccctgggaggcccctcagctcatat
ggaatggatagccgacctcccatggcaatttttgagttgttggattacatcgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataag
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgctttc
atcaagagatctgatgccgaggaggtagacttcgcaggctggctctgctccaccattggg
cttaaccagcccagcacaccaacccacgctgccagcatctga

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