KEGG   Rattus norvegicus (rat): 24654Help
Entry
24654             CDS       T01003                                 

Gene name
Plcb1, PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
Definition
phospholipase C, beta 1 (phosphoinositide-specific) (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:rno00562]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:rno04015]
Environmental Information Processing; Signal transduction; Wnt signaling pathway [PATH:rno04310]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:rno04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:rno04070]
Cellular Processes; Cell communication; Gap junction [PATH:rno04540]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:rno04062]
Organismal Systems; Endocrine system; Insulin secretion [PATH:rno04911]
Organismal Systems; Endocrine system; GnRH signaling pathway [PATH:rno04912]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:rno04915]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:rno04921]
Organismal Systems; Endocrine system; Thyroid hormone synthesis [PATH:rno04918]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:rno04919]
Organismal Systems; Endocrine system; Melanogenesis [PATH:rno04916]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:rno04261]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH:rno04270]
Organismal Systems; Digestive system; Salivary secretion [PATH:rno04970]
Organismal Systems; Digestive system; Gastric acid secretion [PATH:rno04971]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:rno04972]
Organismal Systems; Excretory system; Endocrine and other factor-regulated calcium reabsorption [PATH:rno04961]
Organismal Systems; Nervous system; Glutamatergic synapse [PATH:rno04724]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:rno04725]
Organismal Systems; Nervous system; Dopaminergic synapse [PATH:rno04728]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:rno04726]
Organismal Systems; Nervous system; Long-term potentiation [PATH:rno04720]
Organismal Systems; Nervous system; Long-term depression [PATH:rno04730]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:rno04723]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:rno04750]
Organismal Systems; Environmental adaptation; Circadian entrainment [PATH:rno04713]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:rno05010]
Human Diseases; Neurodegenerative diseases; Huntington's disease [PATH:rno05016]
Human Diseases; Infectious diseases; Amoebiasis [PATH:rno05146]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:rno05142]
Human Diseases; Infectious diseases; African trypanosomiasis [PATH:rno05143]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
UniProt: 
Position
3q36
AA seq 1216 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDPAKVNLKSPSS
EEVQGENAGREFDTPL
NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactatagttactcca
attattttgaggaccgatcctcagggatttttcttttactggacagatcagaataaggag
acggagctgttagatctcagcctcgtcaaggatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttacgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatgggccagacctggtgaatatctcccacctgaatcttgtg
gcttttcaagaggaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
cttcaggtgaccccagaagggcgcattcctcttaaaaacatctatcgactgttttcggca
gaccggaagcgagtggaaactgcgctagaggcttgtagtcttccatcgtcaaggaacgat
tccatccctcaagaggactttactccagatgtatacagagttttcctgaacaatctttgt
ccccgacctgaaattgataacatcttctctgaatttggtgccaaaagcaaaccgtacctt
actgttgatcagatgatggattttatcaaccttaagcagagagatccccggctgaatgaa
atactttacccacctctgaagcaagagcaggtccaagtgttgattgagaagtacgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggcaggaccgctgaggaagagcctgtcatcacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacttctccttttcccatcctcctttcctttgagaaccatgtggattccccgaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctccttatggagcca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcacacaagtcgtcagagggaagtggtaaaaag
aagctctctgagcaagcttccaacacgtacagcgactcttccagcgtgttcgagccttcg
tctccgggagctggggaagcagatacggagagtgatgacgatgacgacgatgatgactgt
aaaaagtcttccatggatgaggggactgctggcagcgaggccatggccacagaagagatg
tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaacttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggactcgaacaactcacg
aagtctccagttgaatttgtcgaatacaacaagatgcagcttagcaggatatatcccaaa
ggaacacgcgtggactcatccaactacatgcctcagctcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtac
gaatacaatgggaagagtggctacaggctgaagccagagttcatgaggaggccagacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagttgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaagaaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaatcctgtctgggaagaagagccaattgtattcaaaaaggtagttctgcct
tctctggcctgtttaaggatagcagcatatgaggaaggaggcaaatttattggccaccgg
atcttgcctgtgcaagcaattcggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacatagaagtcaaagactatgtccca
gacacgtatgcagatgtaattgaagcattatcaaacccaatccgatatgtcaatctgatg
gaacagagagctaagcagttggctgcattgacactggaggatgaagaggaagtcaagaag
gaggctgaccccggggaaacgtcatccgaggctccaagtgaaaccaggacaactccagca
gagaatggggtgaatcacaccgcaacccttgcacccaagccaccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacccgccaaaacagaggatctgattcagagc
gtgttaacagaagtagaggcgcagaccattgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtcaagagacaccacaagaaa
accaccgagctcatcaaggagcataccaccaagtacaatgagattcagaatgactacttg
agaaggagggcagccttggaaaagtccgccaaaaaggatagcaagaagaaatctgaaccc
agcagcccagatcatggctcatccgccattgagcaagacctcgcggccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagtgagaagtaccagaagcgggagcacattaaattgctcattcag
aagttgacagatgttgctgaagagtgtcagaacaatcagttgaagaagctgaaggaaatc
tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaggagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga
tcatacatccaggaggtggtgcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaacttgtggaaaaacacaaggagatccgccagcagatcctggatgagaagccc
aagctgcagatggagctggagcaagaataccaagacaagttcaaaagactgcccctggag
attctggagtttgtacaggaagccatgaaagggaaggttagtgaggacagcaatcacggc
tctgcccctccctcgctggcctcagaccctgctaaggtgaacctcaagtctccctccagt
gaggaggtacaaggagagaacgcgggaagagagtttgatactcctctgtga

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