KEGG   Rattus norvegicus (rat): 24654Help
Entry
24654             CDS       T01003                                 

Gene name
Plcb1, PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
Definition
(RefSeq) phospholipase C beta 1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04062  Chemokine signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04261  Adrenergic signaling in cardiomyocytes
rno04270  Vascular smooth muscle contraction
rno04310  Wnt signaling pathway
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04621  NOD-like receptor signaling pathway
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04916  Melanogenesis
rno04918  Thyroid hormone synthesis
rno04919  Thyroid hormone signaling pathway
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04926  Relaxin signaling pathway
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04934  Cushing's syndrome
rno04961  Endocrine and other factor-regulated calcium reabsorption
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno05010  Alzheimer's disease
rno05016  Huntington's disease
rno05142  Chagas disease (American trypanosomiasis)
rno05143  African trypanosomiasis
rno05146  Amoebiasis
rno05200  Pathways in cancer
Module
rno_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    24654 (Plcb1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    24654 (Plcb1)
   04310 Wnt signaling pathway
    24654 (Plcb1)
   04371 Apelin signaling pathway
    24654 (Plcb1)
   04020 Calcium signaling pathway
    24654 (Plcb1)
   04070 Phosphatidylinositol signaling system
    24654 (Plcb1)
   04072 Phospholipase D signaling pathway
    24654 (Plcb1)
   04071 Sphingolipid signaling pathway
    24654 (Plcb1)
   04022 cGMP - PKG signaling pathway
    24654 (Plcb1)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    24654 (Plcb1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    24654 (Plcb1)
   04621 NOD-like receptor signaling pathway
    24654 (Plcb1)
   04062 Chemokine signaling pathway
    24654 (Plcb1)
  Endocrine system
   04911 Insulin secretion
    24654 (Plcb1)
   04922 Glucagon signaling pathway
    24654 (Plcb1)
   04912 GnRH signaling pathway
    24654 (Plcb1)
   04915 Estrogen signaling pathway
    24654 (Plcb1)
   04921 Oxytocin signaling pathway
    24654 (Plcb1)
   04926 Relaxin signaling pathway
    24654 (Plcb1)
   04918 Thyroid hormone synthesis
    24654 (Plcb1)
   04919 Thyroid hormone signaling pathway
    24654 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    24654 (Plcb1)
   04916 Melanogenesis
    24654 (Plcb1)
   04924 Renin secretion
    24654 (Plcb1)
   04925 Aldosterone synthesis and secretion
    24654 (Plcb1)
   04927 Cortisol synthesis and secretion
    24654 (Plcb1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    24654 (Plcb1)
   04270 Vascular smooth muscle contraction
    24654 (Plcb1)
  Digestive system
   04970 Salivary secretion
    24654 (Plcb1)
   04971 Gastric acid secretion
    24654 (Plcb1)
   04972 Pancreatic secretion
    24654 (Plcb1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    24654 (Plcb1)
  Nervous system
   04724 Glutamatergic synapse
    24654 (Plcb1)
   04725 Cholinergic synapse
    24654 (Plcb1)
   04728 Dopaminergic synapse
    24654 (Plcb1)
   04726 Serotonergic synapse
    24654 (Plcb1)
   04720 Long-term potentiation
    24654 (Plcb1)
   04730 Long-term depression
    24654 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    24654 (Plcb1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    24654 (Plcb1)
  Environmental adaptation
   04713 Circadian entrainment
    24654 (Plcb1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    24654 (Plcb1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    24654 (Plcb1)
   05016 Huntington's disease
    24654 (Plcb1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    24654 (Plcb1)
   04934 Cushing's syndrome
    24654 (Plcb1)
  Infectious diseases
   05146 Amoebiasis
    24654 (Plcb1)
   05142 Chagas disease (American trypanosomiasis)
    24654 (Plcb1)
   05143 African trypanosomiasis
    24654 (Plcb1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     24654 (Plcb1)
Membrane trafficking [BR:rno04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    24654 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    24654 (Plcb1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like DUF1154
Motif
Other DBs
NCBI-GeneID: 24654
NCBI-ProteinID: NP_001071109
RGD: 3344
Ensembl: ENSRNOG00000004810
UniProt: P10687
Position
3q36
AA seq 1216 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDPAKVNLKSPSS
EEVQGENAGREFDTPL
NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactatagttactcca
attattttgaggaccgatcctcagggatttttcttttactggacagatcagaataaggag
acggagctgttagatctcagcctcgtcaaggatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttacgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatgggccagacctggtgaatatctcccacctgaatcttgtg
gcttttcaagaggaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
cttcaggtgaccccagaagggcgcattcctcttaaaaacatctatcgactgttttcggca
gaccggaagcgagtggaaactgcgctagaggcttgtagtcttccatcgtcaaggaacgat
tccatccctcaagaggactttactccagatgtatacagagttttcctgaacaatctttgt
ccccgacctgaaattgataacatcttctctgaatttggtgccaaaagcaaaccgtacctt
actgttgatcagatgatggattttatcaaccttaagcagagagatccccggctgaatgaa
atactttacccacctctgaagcaagagcaggtccaagtgttgattgagaagtacgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggcaggaccgctgaggaagagcctgtcatcacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacttctccttttcccatcctcctttcctttgagaaccatgtggattccccgaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctccttatggagcca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcacacaagtcgtcagagggaagtggtaaaaag
aagctctctgagcaagcttccaacacgtacagcgactcttccagcgtgttcgagccttcg
tctccgggagctggggaagcagatacggagagtgatgacgatgacgacgatgatgactgt
aaaaagtcttccatggatgaggggactgctggcagcgaggccatggccacagaagagatg
tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaacttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggactcgaacaactcacg
aagtctccagttgaatttgtcgaatacaacaagatgcagcttagcaggatatatcccaaa
ggaacacgcgtggactcatccaactacatgcctcagctcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtac
gaatacaatgggaagagtggctacaggctgaagccagagttcatgaggaggccagacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagttgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaagaaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaatcctgtctgggaagaagagccaattgtattcaaaaaggtagttctgcct
tctctggcctgtttaaggatagcagcatatgaggaaggaggcaaatttattggccaccgg
atcttgcctgtgcaagcaattcggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacatagaagtcaaagactatgtccca
gacacgtatgcagatgtaattgaagcattatcaaacccaatccgatatgtcaatctgatg
gaacagagagctaagcagttggctgcattgacactggaggatgaagaggaagtcaagaag
gaggctgaccccggggaaacgtcatccgaggctccaagtgaaaccaggacaactccagca
gagaatggggtgaatcacaccgcaacccttgcacccaagccaccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacccgccaaaacagaggatctgattcagagc
gtgttaacagaagtagaggcgcagaccattgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtcaagagacaccacaagaaa
accaccgagctcatcaaggagcataccaccaagtacaatgagattcagaatgactacttg
agaaggagggcagccttggaaaagtccgccaaaaaggatagcaagaagaaatctgaaccc
agcagcccagatcatggctcatccgccattgagcaagacctcgcggccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagtgagaagtaccagaagcgggagcacattaaattgctcattcag
aagttgacagatgttgctgaagagtgtcagaacaatcagttgaagaagctgaaggaaatc
tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaggagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga
tcatacatccaggaggtggtgcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaacttgtggaaaaacacaaggagatccgccagcagatcctggatgagaagccc
aagctgcagatggagctggagcaagaataccaagacaagttcaaaagactgcccctggag
attctggagtttgtacaggaagccatgaaagggaaggttagtgaggacagcaatcacggc
tctgcccctccctcgctggcctcagaccctgctaaggtgaacctcaagtctccctccagt
gaggaggtacaaggagagaacgcgggaagagagtttgatactcctctgtga

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