KEGG   Rattus norvegicus (rat): 25738Help
Entry
25738             CDS       T01003                                 

Gene name
Plcg1, PPLCA
Definition
phospholipase C, gamma 1 (EC:3.1.4.11)
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:rno00562]
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:rno04014]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:rno04015]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:rno04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:rno04370]
Environmental Information Processing; Signal transduction; NF-kappa B signaling pathway [PATH:rno04064]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:rno04066]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:rno04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:rno04070]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:rno04650]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:rno04660]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:rno04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:rno04666]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:rno04670]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:rno04919]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:rno04722]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:rno04750]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:rno05206]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:rno05205]
Human Diseases; Cancers; Glioma [PATH:rno05214]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:rno05223]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:rno05169]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
3q42
AA seq 1290 aa AA seqDB search
MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDFEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRT
GERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgtcgggaccccctgcgccaacggctgcgggcccagcgcgccctccgaagcg
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccagaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggtgcggacaaaatcgaggggtccatcgatatccgagaaatcaaggag
atccgcccagggaagacttcccgggactttgaccgctaccaagaagaccctgccttccgg
ccagatcagtcacactgttttgtcatcctctatggaatggaattccgcctgaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctc
atggaagatacgctgcaggcggccacacccctgcaaattgagagatggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaggacctgaagaacatg
ctgtcacaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
tttgaacagcgcagcggggacatcacctatgggcagtttgctcagctttaccgcagcctc
atgtacagcgcccagaagacgatggaccttccgttcttggaaaccaacactttgaggact
ggagagcggccagagctttgccaggtgtccctttctgagttccagcagttccttcttgag
taccagggggagctgtgggctgtcgaccggcttcaggtgcaggaatttatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctggatgccgtgtgcccagaa
accatgaacaacccactgtctcactattggatctcttcctcgcataatacgtatctgact
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgaggatgggc
tgtcgctgcatcgagttggactgctgggatgggccagatgggatgccagtcatttaccat
gggcacaccctcaccaccaagattaagttctcagatgtcctgcacaccatcaaggagcac
gcgttcgtagcctcagagtaccctgtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaggaaggtgctcggtgacacgctcctcaccaag
cccgtggacattgccgctgatgggctcccttctcccaaccagctcaagaggaagatcctg
attaagcataagaagctggctgagggcagtgcctatgaggaggtgcctacctctgtgatg
tactctgagaatgacatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtacccccactactttgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggaaatgaggatgaagaggagccgaaggaggccagtggc
agcacagagctgcactcgagcgagaagtggttccacgggaagctcggggctgggcgcgac
gggcggcacattgctgagcgcctgctcaccgagtactgcatagagactggggctcccgat
ggctccttcctagtgcgagaaagtgagaccttcgtgggggactacacgctgtctttttgg
cggaatgggaaagtccagcactgccgtatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtgcccctgcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagacg
aatgcccatgagagcaaagagtggtaccacgcaagcctgactagagctcaggctgaacac
atgctgatgcgagtaccccgtgatggggccttcctggtgcggaagcgcaacgagcccaac
tcctatgccatctctttccgggctgagggaaagatcaagcactgccgagtacagcaggaa
ggccagactgtgatgctggggaactctgagtttgacagcctggtcgacctcatcagctac
tatgagaagcatcccctgtaccgcaaaatgaaactgcgctaccccatcaacgaggaggcg
ctggagaagattgggacagctgaacccgattatggggcactgtatgagggccgcaaccct
ggtttctatgtggaggccaaccctatgccaactttcaagtgtgcagtaaaagctctcttc
gactacaaggcccagagagaggatgagctgacttttaccaagagcgccatcatccagaat
gtggaaaagcaagatggtggctggtggcgtggggactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaatccagcaatcctagagccggagagggag
catctggatgagaacagcccactgggggacttgctgcgaggggtcttagatgtgccagcc
tgccagatcgccattcgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccgtcagtggctcagtggtccctagacgttgccgctgactcacaggaggagttgcag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggcttactgagggg
aagatgatggagaggaggaagaagatcgccttggagctctccgagctcgtggtctactgc
cggcctgttccctttgacgaagagaagattggcacagaacgcgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctctcgcatctaccctaagggtcagaggctggactcc
tccaattatgaccctctgcccatgtggatctgtggcagccagcttgtagctctcaatttt
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggtggacactgt
ggctatgtgctgcagccaagcaccatgagagatgaagcctttgacccctttgataagagc
agtctccgaggtctggagccctgtgtcatttgcattgaggtgctgggggccaggcatctg
ccgaagaatggccggggtattgtgtgtcctttcgtggagattgaagtggctggggcagag
tacgacagcaccaagcagaagacagagtttgtagtggacaatggactgaaccctgtgtgg
cctgcaaagcccttccacttccagatcagtaacccagagtttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacattttccctgctaaggagaatggtgacctc
agccctttcagtggtacatccctaagggaacgggcctcagatgcctccagccagctgttc
catgtccgggcccgggaagggtcctttgaagccagataccagcagccatttgaagacttc
cgcatctcgcaggagcatctcgcagaccattttgacagtcgggaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag

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