KEGG   Rattus norvegicus (rat): 25738Help
Entry
25738             CDS       T01003                                 

Gene name
Plcg1, PPLCA
Definition
phospholipase C, gamma 1 (EC:3.1.4.11)
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    25738 (Plcg1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    25738 (Plcg1)
   04015 Rap1 signaling pathway
    25738 (Plcg1)
   04012 ErbB signaling pathway
    25738 (Plcg1)
   04370 VEGF signaling pathway
    25738 (Plcg1)
   04064 NF-kappa B signaling pathway
    25738 (Plcg1)
   04066 HIF-1 signaling pathway
    25738 (Plcg1)
   04020 Calcium signaling pathway
    25738 (Plcg1)
   04070 Phosphatidylinositol signaling system
    25738 (Plcg1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    25738 (Plcg1)
   04660 T cell receptor signaling pathway
    25738 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    25738 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    25738 (Plcg1)
   04670 Leukocyte transendothelial migration
    25738 (Plcg1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    25738 (Plcg1)
  Nervous system
   04722 Neurotrophin signaling pathway
    25738 (Plcg1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25738 (Plcg1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    25738 (Plcg1)
   05231 Choline metabolism in cancer
    25738 (Plcg1)
   05206 MicroRNAs in cancer
    25738 (Plcg1)
   05205 Proteoglycans in cancer
    25738 (Plcg1)
   05214 Glioma
    25738 (Plcg1)
   05223 Non-small cell lung cancer
    25738 (Plcg1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    25738 (Plcg1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     25738 (Plcg1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
3q42
AA seq 1290 aa AA seqDB search
MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDFEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRT
GERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgtcgggaccccctgcgccaacggctgcgggcccagcgcgccctccgaagcg
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccagaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggtgcggacaaaatcgaggggtccatcgatatccgagaaatcaaggag
atccgcccagggaagacttcccgggactttgaccgctaccaagaagaccctgccttccgg
ccagatcagtcacactgttttgtcatcctctatggaatggaattccgcctgaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctc
atggaagatacgctgcaggcggccacacccctgcaaattgagagatggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaggacctgaagaacatg
ctgtcacaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
tttgaacagcgcagcggggacatcacctatgggcagtttgctcagctttaccgcagcctc
atgtacagcgcccagaagacgatggaccttccgttcttggaaaccaacactttgaggact
ggagagcggccagagctttgccaggtgtccctttctgagttccagcagttccttcttgag
taccagggggagctgtgggctgtcgaccggcttcaggtgcaggaatttatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctggatgccgtgtgcccagaa
accatgaacaacccactgtctcactattggatctcttcctcgcataatacgtatctgact
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgaggatgggc
tgtcgctgcatcgagttggactgctgggatgggccagatgggatgccagtcatttaccat
gggcacaccctcaccaccaagattaagttctcagatgtcctgcacaccatcaaggagcac
gcgttcgtagcctcagagtaccctgtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaggaaggtgctcggtgacacgctcctcaccaag
cccgtggacattgccgctgatgggctcccttctcccaaccagctcaagaggaagatcctg
attaagcataagaagctggctgagggcagtgcctatgaggaggtgcctacctctgtgatg
tactctgagaatgacatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtacccccactactttgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggaaatgaggatgaagaggagccgaaggaggccagtggc
agcacagagctgcactcgagcgagaagtggttccacgggaagctcggggctgggcgcgac
gggcggcacattgctgagcgcctgctcaccgagtactgcatagagactggggctcccgat
ggctccttcctagtgcgagaaagtgagaccttcgtgggggactacacgctgtctttttgg
cggaatgggaaagtccagcactgccgtatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtgcccctgcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagacg
aatgcccatgagagcaaagagtggtaccacgcaagcctgactagagctcaggctgaacac
atgctgatgcgagtaccccgtgatggggccttcctggtgcggaagcgcaacgagcccaac
tcctatgccatctctttccgggctgagggaaagatcaagcactgccgagtacagcaggaa
ggccagactgtgatgctggggaactctgagtttgacagcctggtcgacctcatcagctac
tatgagaagcatcccctgtaccgcaaaatgaaactgcgctaccccatcaacgaggaggcg
ctggagaagattgggacagctgaacccgattatggggcactgtatgagggccgcaaccct
ggtttctatgtggaggccaaccctatgccaactttcaagtgtgcagtaaaagctctcttc
gactacaaggcccagagagaggatgagctgacttttaccaagagcgccatcatccagaat
gtggaaaagcaagatggtggctggtggcgtggggactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaatccagcaatcctagagccggagagggag
catctggatgagaacagcccactgggggacttgctgcgaggggtcttagatgtgccagcc
tgccagatcgccattcgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccgtcagtggctcagtggtccctagacgttgccgctgactcacaggaggagttgcag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggcttactgagggg
aagatgatggagaggaggaagaagatcgccttggagctctccgagctcgtggtctactgc
cggcctgttccctttgacgaagagaagattggcacagaacgcgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctctcgcatctaccctaagggtcagaggctggactcc
tccaattatgaccctctgcccatgtggatctgtggcagccagcttgtagctctcaatttt
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggtggacactgt
ggctatgtgctgcagccaagcaccatgagagatgaagcctttgacccctttgataagagc
agtctccgaggtctggagccctgtgtcatttgcattgaggtgctgggggccaggcatctg
ccgaagaatggccggggtattgtgtgtcctttcgtggagattgaagtggctggggcagag
tacgacagcaccaagcagaagacagagtttgtagtggacaatggactgaaccctgtgtgg
cctgcaaagcccttccacttccagatcagtaacccagagtttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacattttccctgctaaggagaatggtgacctc
agccctttcagtggtacatccctaagggaacgggcctcagatgcctccagccagctgttc
catgtccgggcccgggaagggtcctttgaagccagataccagcagccatttgaagacttc
cgcatctcgcaggagcatctcgcagaccattttgacagtcgggaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag

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