KEGG   Rattus norvegicus (rat): 58960Help
Entry
58960             CDS       T01003                                 

Gene name
Map2k2, Prkmk2
Definition
mitogen activated protein kinase kinase 2 (EC:2.7.12.2)
Orthology
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    58960 (Map2k2)
   04015 Rap1 signaling pathway
    58960 (Map2k2)
   04010 MAPK signaling pathway
    58960 (Map2k2)
   04012 ErbB signaling pathway
    58960 (Map2k2)
   04370 VEGF signaling pathway
    58960 (Map2k2)
   04066 HIF-1 signaling pathway
    58960 (Map2k2)
   04068 FoxO signaling pathway
    58960 (Map2k2)
   04024 cAMP signaling pathway
    58960 (Map2k2)
   04022 cGMP - PKG signaling pathway
    58960 (Map2k2)
   04151 PI3K-Akt signaling pathway
    58960 (Map2k2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    58960 (Map2k2)
  Cellular commiunity
   04540 Gap junction
    58960 (Map2k2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    58960 (Map2k2)
   04650 Natural killer cell mediated cytotoxicity
    58960 (Map2k2)
   04660 T cell receptor signaling pathway
    58960 (Map2k2)
   04662 B cell receptor signaling pathway
    58960 (Map2k2)
   04664 Fc epsilon RI signaling pathway
    58960 (Map2k2)
  Endocrine system
   04910 Insulin signaling pathway
    58960 (Map2k2)
   04912 GnRH signaling pathway
    58960 (Map2k2)
   04915 Estrogen signaling pathway
    58960 (Map2k2)
   04917 Prolactin signaling pathway
    58960 (Map2k2)
   04921 Oxytocin signaling pathway
    58960 (Map2k2)
   04919 Thyroid hormone signaling pathway
    58960 (Map2k2)
   04916 Melanogenesis
    58960 (Map2k2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    58960 (Map2k2)
  Nervous system
   04720 Long-term potentiation
    58960 (Map2k2)
   04730 Long-term depression
    58960 (Map2k2)
   04722 Neurotrophin signaling pathway
    58960 (Map2k2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    58960 (Map2k2)
   05206 MicroRNAs in cancer
    58960 (Map2k2)
   05205 Proteoglycans in cancer
    58960 (Map2k2)
   05214 Glioma
    58960 (Map2k2)
   05216 Thyroid cancer
    58960 (Map2k2)
   05221 Acute myeloid leukemia
    58960 (Map2k2)
   05220 Chronic myeloid leukemia
    58960 (Map2k2)
   05218 Melanoma
    58960 (Map2k2)
   05211 Renal cell carcinoma
    58960 (Map2k2)
   05219 Bladder cancer
    58960 (Map2k2)
   05215 Prostate cancer
    58960 (Map2k2)
   05213 Endometrial cancer
    58960 (Map2k2)
   05223 Non-small cell lung cancer
    58960 (Map2k2)
  Neurodegenerative diseases
   05020 Prion diseases
    58960 (Map2k2)
  Infectious diseases
   05164 Influenza A
    58960 (Map2k2)
   05161 Hepatitis B
    58960 (Map2k2)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     58960 (Map2k2)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   58960 (Map2k2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
7q11
AA seq 400 aa AA seqDB search
MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADL
KLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgttaccggcactcaccatcaaccctaccatcgctgag
ggcccgtcccccaccagcgagggcgcctccgaggcacacctggtggacctccagaagaag
ttggaagagctggacctggatgaacagcagaggaagcggctggaggccttccttacccag
aaggccaaggttggtgagctcaaggacgacgactttgagagaatctcagaactgggtgca
ggcaatggcggcgtggtcacaaaggcccggcataggccctctggcctcatcatggccaga
aagctgatccacctggagatcaagccagctgtccgcaaccagatcatccgggagctgcag
gtgctgcatgagtgcaactcaccgtacatcgtgggcttttatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggtggctcactggaccaggtactgaag
gaggccaagcgcattcccgaggacatcttagggaaggtcagcattgcggtgctccggggc
ctggcgtacctccgcgagaagcaccagatcatgcatagagatgtgaagccctccaacatt
ctggtgaactctcgtggagagattaagctgtgcgacttcggagtgagcggccagttgatt
gactccatggccaactcatttgtagggacacgctcctacatgtccccagaacggctgcag
ggcacccactactctgtgcagtcggacatctggagcatggggctgtcgctggtggagctg
gccatcgggaggtaccccatccccccacctgatgccaaggaactagaggccagctttggc
cggcctgtggtggacggggcagatggagagccccatagtgtctcaccgcggccccggccc
cctggacgccccatcagtggtcatgggatggacagccgaccagccatggccatctttgag
ctgctggactacatagtgaatgagccacctcccaagctgcccagtggtgtgttcagctca
gacttccaggagtttgtgaataaatgtctcattaagaacccagcagagcgtgcagacctc
aagctgctgacgaaccatgccttcatcaaacgctctgagggggaggacgtggacttcgct
ggctggctatgcagaaccctgcggctgaagcagcccagcacacccacgcgtactgcagtg
tga

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