KEGG   Rattus norvegicus (rat): 84351Help
Entry
84351             CDS       R.norvegicus                           
Gene name Ikbkb
Definition inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase beta (EC:2.7.11.10)
Orthology K07209  inhibitor of nuclear factor kappa-B kinase beta subunit
        [EC:2.7.11.10]
Pathway rno04010  MAPK signaling pathway
rno04062  Chemokine signaling pathway
rno04210  Apoptosis
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04722  Neurotrophin signaling pathway
rno04910  Insulin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04930  Type II diabetes mellitus
rno05200  Pathways in cancer
rno05212  Pancreatic cancer
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
Class Metabolism; Enzyme Families; Protein kinases
Environmental Information Processing; Signal Transduction; MAPK
signaling pathway [PATH:rno04010]
Cellular Processes; Cell Growth and Death; Apoptosis [PATH:rno04210]
Organismal Systems; Immune System; Toll-like receptor signaling
pathway [PATH:rno04620]
Organismal Systems; Immune System; NOD-like receptor signaling
pathway [PATH:rno04621]
Organismal Systems; Immune System; RIG-I-like receptor signaling
pathway [PATH:rno04622]
Organismal Systems; Immune System; Cytosolic DNA-sensing pathway
[PATH:rno04623]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Immune System; B cell receptor signaling pathway
[PATH:rno04662]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; Adipocytokine signaling
pathway [PATH:rno04920]
Organismal Systems; Nervous System; Neurotrophin signaling pathway
[PATH:rno04722]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Pancreatic cancer [PATH:rno05212]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:rno05220]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Cancers; Small cell lung cancer [PATH:rno05222]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:rno04930]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: Pkinase Pkinase_Tyr IKKbetaNEMObind Kdo YrbL-PhoP_reg APH
PROSITE: PROTEIN_KINASE_ST PROTEIN_KINASE_DOM
Motif
Other DBs NCBI-GI: 158508716
NCBI-GeneID: 84351
RGD: 621375
RATMAP: ENSRNOG00000019073
Ensembl: ENSRNOG00000019073
UniProt: Q9QY78
Position 16q12.5
AA seq 757 aa AA seqDB search
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQVTGEQIAIKQCRQELSPKNRDRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPFPNNLNSVLAERLEKWLQLMLTWQPRQRGVDPQYGPNGCF
RALDDILNLKLVHILNMVTGTIHTYPVMEDESLQSLKTRIREDTGILETDQELLQEAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLFDNSKMSYETQITPRPQPESVSCVLQEPKRN
LSFFQMRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVEQCGRENDVKVLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQDMVRLLLQAIQS
FEKKVRVIYSQLSKTVVCKQKALELLPKVEEVVRLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGHLMSQPSSACDSLPDSDKKSEELVAEAHALCSRLE
SALQDTVKQQDRSFTTLDWSWLQMEDEERCGLEQACD
NT seq 2274 nt NT seq  +upstreamnt  +downstreamnt
atgagctggtcaccttctctcccaacccagacatgtggggcctgggaaatgaaagaacgc
ctcggaactgggggatttggaaacgtcatccggtggcacaatcaggtgacaggtgaacaa
attgccatcaagcaatgccgacaggagctcagccccaagaaccgcgatcgctggtgccta
gagatccagatcatgagaaggctgaaccatcccaacgtggtggccgcccgggatgtccca
gaggggatgcagaacttggcacccaatgatttgcctctgctggccatggagtactgccaa
ggaggagacctccggagatacttgaaccagttcgaaaactgctgtggcctccgggaagga
gccatcctcaccctgctgagtgacatagcatcggctcttagataccttcatgaaaacaga
atcatccaccgggacctgaagccagagaacattgtcctacagcaaggagagaaaagatta
atacacaaaattattgatctaggatatgccaaggagctggatcagggcagtctgtgcacg
tcatttgtggggaccctgcaatacctggccccagagcttctggagcagcagaagtacacc
gtgactgttgactactggagcttcggcaccctggcctttgaatgcatcaccggcttccgg
ccctttctccctaactggcagcctgtgcagtggcactctaaagtccggcagaagagcgaa
gtggacattgttgttagcgaggacttgaacggaacagtgaagttctcaagttccttaccc
ttccccaataatctcaacagtgtcctggctgagcgtctggagaagtggcttcagctgatg
ctcacgtggcaacctcggcaaaggggcgtggacccccagtacggtcccaatggctgtttc
agggccctcgatgacatcttgaacttaaagctggttcatatcttgaacatggtcacaggc
accattcacacataccctgtgatggaggatgaaagtctgcagagcttaaaaaccagaatc
cgggaagacacagggatcctggagacagaccaggaactgctgcaggaggcagggctggtg
ctgctccctgacaagcctgctactcagtgcatctcagacagcaagacaaatgagggcctc
acactggacatggatctcgtctttctctttgacaacagtaaaatgtcctatgagactcag
atcaccccccgaccccaacctgagagcgtcagctgtgtccttcaggagcccaagcggaac
ctctccttcttccagatgaggaaagtgtggggccaagtctggcacagcatccaaacgctg
aaggaagactgtaaccggctgcagcagggacagcgagctgccatgatgaacctccttcgg
aataacagctgcctctccaagatgaagaatgccatggcctccacggcgcagcagctcaag
gccaagttggacttcttcaaaaccagcatccagattgacctggagaagtacagggagcag
acggagtttggcatcacatcggacaaactgctgctggcctggcgggaaatggagcaggcc
gtggagcagtgtgggcgggagaatgacgtgaaggtcctggtagaacggatgatggcactg
cagaccgacattgtggacctacagaggagcccgatgggtcggaagcaggggggcaccttg
gatgacctagaggaacaagcaagagaactctacagaagactcagggagaagccaagagac
caaaggacagaaggtgacagccaggatatggtacggctgctgctgcaagccatccagagc
ttcgagaagaaagtgcgggtgatttactctcagctcagtaagaccgtggtttgtaagcag
aaggccctggagctgctgcccaaagtagaagaggtggtgaggctcatgaacgaggatgag
aagactgtggtccggctccaggagaagcggcagaaggagctctggaacctcctgaagatc
gcctgtagcaaagtccgaggtccggtgagtggaagcccagatagcatgaatgtgtctcga
cttagtcaccctggtcatctaatgtcccagccttccagtgcctgtgacagcttacctgat
tcagacaagaaaagtgaagaactggtggccgaagcacacgccctctgctcccggctggaa
agcgcgctgcaggacacggtgaagcagcaggaccgaagcttcacgaccctagactggagc
tggttacagatggaggatgaagaaaggtgtggcctggagcaggcctgtgactga
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