KEGG   PATHWAY: sce04120Help
Entry
sce04120                    Pathway                                

Name
Ubiquitin mediated proteolysis - Saccharomyces cerevisiae (budding yeast)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
sce04120  Ubiquitin mediated proteolysis
sce04120

Ortholog table
Module
sce_M00379  SCF-MET30 complex [PATH:sce04120]
sce_M00389  APC/C complex [PATH:sce04120]
sce_M00407  SCF-CDC4 complex [PATH:sce04120]
sce_M00411  SCF-GRR1 complex [PATH:sce04120]
Other DBs
BSID: 959
GO: 0016567
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YKL210W  UBA1; E1 ubiquitin-activating protein UBA1 [KO:K03178] [EC:6.2.1.45]
YPR180W  AOS1; E1 ubiquitin-activating protein AOS1 [KO:K10684] [EC:6.2.1.45]
YDR390C  UBA2; E1 ubiquitin-activating protein UBA2 [KO:K10685] [EC:6.2.1.45]
YPR066W  UBA3; NEDD8-activating protein UBA3 [KO:K10686] [EC:6.2.1.45]
YGL058W  RAD6; E2 ubiquitin-conjugating protein RAD6 [KO:K10573] [EC:2.3.2.23]
YOR339C  UBC11; putative E2 ubiquitin-protein ligase UBC11 [KO:K06688] [EC:2.3.2.23]
YDR059C  UBC5; E2 ubiquitin-conjugating protein UBC5 [KO:K06689] [EC:2.3.2.23]
YBR082C  UBC4; E2 ubiquitin-conjugating protein UBC4 [KO:K06689] [EC:2.3.2.23]
YMR022W  UBC7; E2 ubiquitin-conjugating protein UBC7 [KO:K04555] [EC:2.3.2.23]
YEL012W  UBC8; E2 ubiquitin-conjugating protein UBC8 [KO:K10576] [EC:2.3.2.23]
YDL064W  UBC9; E2 SUMO-conjugating protein UBC9 [KO:K10577]
YER100W  UBC6; E2 ubiquitin-conjugating protein UBC6 [KO:K04554] [EC:2.3.2.23]
YLR306W  UBC12; NEDD8-conjugating protein UBC12 [KO:K10579]
YDR092W  UBC13; E2 ubiquitin-conjugating protein UBC13 [KO:K10580] [EC:2.3.2.23]
YDR054C  CDC34; SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 [KO:K02207] [EC:2.3.2.23]
YDR177W  UBC1; E2 ubiquitin-conjugating protein UBC1 [KO:K04649] [EC:2.3.2.23]
YGL141W  HUL5; ubiquitin-ubiquitin ligase HUL5 [KO:K10589] [EC:2.3.2.26]
YKL010C  UFD4; putative ubiquitin-protein ligase UFD4 [KO:K10590] [EC:2.3.2.26]
YER125W  RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO:K10591] [EC:2.3.2.26]
YDR457W  TOM1; E3 ubiquitin-protein ligase TOM1 [KO:K10592] [EC:2.3.2.26]
YDL190C  UFD2; ubiquitin-ubiquitin ligase UFD2 [KO:K10597] [EC:2.3.2.27]
YLL036C  PRP19; E3 ubiquitin-protein ligase PRP19 [KO:K10599] [EC:2.3.2.27]
YDR409W  SIZ1; SUMO ligase SIZ1 [KO:K04706]
YOL013C  HRD1; E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
YOL133W  HRT1; SCF ubiquitin ligase complex subunit HRT1 [KO:K03868] [EC:2.3.2.32]
YDL132W  CDC53; cullin CDC53 [KO:K03347]
YDR328C  SKP1; SCF ubiquitin ligase subunit SKP1 [KO:K03094]
YFL009W  CDC4; SCF ubiquitin ligase complex subunit CDC4 [KO:K03361]
YIL046W  MET30; ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 [KO:K10259]
YJR090C  GRR1; SCF ubiquitin ligase complex subunit GRR1 [KO:K03360]
YPL046C  ELC1; elongin C [KO:K03872]
YGR003W  CUL3; cullin CUL3 [KO:K03869]
YDR030C  RAD28; Rad28p [KO:K10570]
YDL008W  APC11; anaphase promoting complex subunit 11 [KO:K03358]
YLR127C  APC2; anaphase promoting complex subunit 2 [KO:K03349]
YGL116W  CDC20; ubiquitin-protein transferase activating protein CDC20 [KO:K03363]
YGL003C  CDH1; Cdh1p [KO:K03364]
YNL172W  APC1; anaphase promoting complex subunit 1 [KO:K03348]
YBL084C  CDC27; anaphase promoting complex subunit CDC27 [KO:K03350]
YDR118W  APC4; anaphase promoting complex subunit 4 [KO:K03351]
YOR249C  APC5; anaphase promoting complex subunit 5 [KO:K03352]
YKL022C  CDC16; anaphase promoting complex subunit CDC16 [KO:K03353]
YHR166C  CDC23; anaphase promoting complex subunit CDC23 [KO:K03355]
YLR102C  APC9; anaphase promoting complex subunit 9 [KO:K03356]
YGL240W  DOC1; anaphase promoting complex subunit DOC1 [KO:K03357]
YFR036W  CDC26; anaphase promoting complex subunit CDC26 [KO:K03359]
YDR260C  SWM1; Swm1p [KO:K12416]
Reference
PMID:16922370 (Japanese)
  Authors
Kamura T.
  Title
[Cullin-based E3 family] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408 (Japanese)
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367 (Japanese)
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
KO pathway
ko04120   

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