KEGG PATHWAY: sce04120

PATHWAY: sce04120

Entry

sce04120 Pathway

Name

Ubiquitin mediated proteolysis - Saccharomyces cerevisiae (budding yeast)

Description

Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

sce04120

Ubiquitin mediated proteolysis

Module

sce_M00379	SCF-MET30 complex [PATH:sce04120]
sce_M00389	APC/C complex [PATH:sce04120]
sce_M00407	SCF-CDC4 complex [PATH:sce04120]
sce_M00411	SCF-GRR1 complex [PATH:sce04120]

Other DBs

BSID:

959

GO:

0016567

Organism

Saccharomyces cerevisiae (budding yeast) [GN:sce]

Gene

YKL210W	UBA1; E1 ubiquitin-activating protein UBA1 [KO:K03178] [EC:6.3.2.19]
YPR180W	AOS1; E1 ubiquitin-activating protein AOS1 [KO:K10684] [EC:6.3.2.19]
YDR390C	UBA2; E1 ubiquitin-activating protein UBA2 [KO:K10685] [EC:6.3.2.19]
YPR066W	UBA3; NEDD8-activating protein UBA3 [KO:K10686] [EC:6.3.2.19]
YGL058W	RAD6; E2 ubiquitin-conjugating protein RAD6 [KO:K10573] [EC:6.3.2.19]
YOR339C	UBC11; putative E2 ubiquitin-protein ligase UBC11 [KO:K06688] [EC:6.3.2.19]
YBR082C	UBC4; E2 ubiquitin-conjugating protein UBC4 [KO:K06689] [EC:6.3.2.19]
YDR059C	UBC5; E2 ubiquitin-conjugating protein UBC5 [KO:K06689] [EC:6.3.2.19]
YMR022W	UBC7; E2 ubiquitin-conjugating protein UBC7 [KO:K04555] [EC:6.3.2.19]
YEL012W	UBC8; E2 ubiquitin-conjugating protein UBC8 [KO:K10576] [EC:6.3.2.19]
YDL064W	UBC9; E2 SUMO-conjugating protein UBC9 [KO:K10577] [EC:6.3.2.19]
YER100W	UBC6; E2 ubiquitin-conjugating protein UBC6 [KO:K04554] [EC:6.3.2.19]
YLR306W	UBC12; NEDD8-conjugating protein UBC12 [KO:K10579] [EC:6.3.2.19]
YDR092W	UBC13; E2 ubiquitin-conjugating protein UBC13 [KO:K10580] [EC:6.3.2.19]
YDR054C	CDC34; SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 [KO:K02207] [EC:6.3.2.19]
YDR177W	UBC1; E2 ubiquitin-conjugating protein UBC1 [KO:K04649] [EC:6.3.2.19]
YGL141W	HUL5; ubiquitin-ubiquitin ligase HUL5 [KO:K10589] [EC:6.3.2.19]
YKL010C	UFD4; putative ubiquitin-protein ligase UFD4 [KO:K10590] [EC:6.3.2.19]
YER125W	RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO:K10591] [EC:6.3.2.19]
YDR457W	TOM1; E3 ubiquitin-protein ligase TOM1 [KO:K10592] [EC:6.3.2.19]
YDL190C	UFD2; ubiquitin-ubiquitin ligase UFD2 [KO:K10597] [EC:6.3.2.19]
YLL036C	PRP19; E3 ubiquitin-protein ligase PRP19 [KO:K10599] [EC:6.3.2.19]
YDR409W	SIZ1; SUMO ligase SIZ1 [KO:K04706] [EC:6.3.2.-]
YOL013C	HRD1; E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:6.3.2.19]
YOL133W	HRT1; SCF ubiquitin ligase complex subunit HRT1 [KO:K03868]
YDL132W	CDC53; cullin CDC53 [KO:K03347]
YDR328C	SKP1; Skp1p [KO:K03094]
YFL009W	CDC4; SCF ubiquitin ligase complex subunit CDC4 [KO:K03361]
YIL046W	MET30; Met30p [KO:K10259]
YJR090C	GRR1; SCF ubiquitin ligase complex subunit GRR1 [KO:K03360]
YPL046C	ELC1; elongin C [KO:K03872]
YGR003W	CUL3; cullin CUL3 [KO:K03869]
YDR030C	RAD28; Rad28p [KO:K10570]
YDL008W	APC11; anaphase promoting complex subunit 11 [KO:K03358]
YLR127C	APC2; anaphase promoting complex subunit 2 [KO:K03349]
YGL116W	CDC20; Cdc20p [KO:K03363]
YGL003C	CDH1; Cdh1p [KO:K03364]
YNL172W	APC1; anaphase promoting complex subunit 1 [KO:K03348]
YBL084C	CDC27; anaphase promoting complex subunit CDC27 [KO:K03350]
YDR118W	APC4; anaphase promoting complex subunit 4 [KO:K03351]
YOR249C	APC5; anaphase promoting complex subunit 5 [KO:K03352]
YKL022C	CDC16; anaphase promoting complex subunit CDC16 [KO:K03353]
YHR166C	CDC23; anaphase promoting complex subunit CDC23 [KO:K03355]
YLR102C	APC9; anaphase promoting complex subunit 9 [KO:K03356]
YGL240W	DOC1; anaphase promoting complex subunit DOC1 [KO:K03357]
YFR036W	CDC26; anaphase promoting complex subunit CDC26 [KO:K03359]
YDR260C	SWM1; Swm1p [KO:K12416]

Reference

PMID:16922370 (Japanese)

Authors

Kamura T.

Title

[Cullin-based E3 family] Japanese

Journal

Tanpakushitsu Kakusan Koso 51:1167-72 (2006)

Reference

PMID:16922408 (Japanese)

Authors

Matsuda N.

Title

[Overview: hereditary disorders caused by dysfunction of ubiquitylation]

Journal

Tanpakushitsu Kakusan Koso 51:1402-7 (2006)

Reference

PMID:16922367 (Japanese)

Authors

Tokunaga F.

Title

[E2 ubiquitin-conjugating enzymes: structures and functions]

Journal

Tanpakushitsu Kakusan Koso 51:1150-6 (2006)

Reference

PMID:16816840

Authors

Nalepa G, Rolfe M, Harper JW.

Title

Drug discovery in the ubiquitin-proteasome system.

Journal

Nat Rev Drug Discov 5:596-613 (2006)

Reference

PMID:16405856

Authors

Hsu YJ, Goodman SR.

Title

Spectrin and ubiquitination: a review.

Journal

Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)

Reference

PMID:12944364

Authors

Hatakeyama S, Nakayama KI.

Title

Ubiquitylation as a quality control system for intracellular proteins.

Journal

J Biochem 134:1-8 (2003)

Reference

PMID:17588513

Authors

Lee J, Zhou P.

Title

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Journal

Mol Cell 26:775-80 (2007)

KO pathway

ko04120

All links

Pathway (5)   
   KEGG MODULE (4)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG GENES (47)   
All databases (53)   

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