KEGG   Saccharomyces cerevisiae (budding yeast): YML075C
Entry
YML075C           CDS       T00005                                 
Symbol
HMG1
Name
(RefSeq) hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
  KO
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Organism
sce  Saccharomyces cerevisiae (budding yeast)
Pathway
sce00900  Terpenoid backbone biosynthesis
sce01100  Metabolic pathways
sce01110  Biosynthesis of secondary metabolites
Module
sce_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Brite
KEGG Orthology (KO) [BR:sce00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    YML075C (HMG1)
Enzymes [BR:sce01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     YML075C (HMG1)
SSDB
Motif
Pfam: HMG-CoA_red HPIH Sterol-sensing
Other DBs
NCBI-GeneID: 854900
NCBI-ProteinID: NP_013636
SGD: S000004540
UniProt: P12683
Position
XIII:complement(115734..118898)
AA seq 1054 aa
MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVF
ETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPHHYYLLNLNFNSPNETDSI
PELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYDVFSE
NVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQ
CILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEIVFESVSE
EGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLE
MNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVFIN
FYNFGANWVNDAFNSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRI
EDMVLLLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKTEVTK
KSFTAPVQKASTPVLTNKTVISGSKVKSLSSAQSSSSGPSSSSEEDDSRDIESLDKKIRP
LEELEALLSSGNTKQLKNKEVAALVIHGKLPLYALEKKLGDTTRAVAVRRKALSILAEAP
VLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVAS
AMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKKAFNST
SRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSV
SGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMA
GSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIG
GGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSH
MTHNRKPAEPTKPNNLDATDINRLKDGSVTCIKS
NT seq 3165 nt   +upstreamnt  +downstreamnt
atgccgccgctattcaagggactgaaacagatggcaaagccaattgcctatgtttcaaga
ttttcggcgaaacgaccaattcatataatacttttttctctaatcatatccgcattcgct
tatctatccgtcattcagtattacttcaatggttggcaactagattcaaatagtgttttt
gaaactgctccaaataaagactccaacactctatttcaagaatgttcccattactacaga
gattcctctctagatggttgggtatcaatcaccgcgcatgaagctagtgagttaccagcc
ccacaccattactatctattaaacctgaacttcaatagtcctaatgaaactgactccatt
ccagaactagctaacacggtttttgagaaagataatacaaaatatattctgcaagaagat
ctcagtgtttccaaagaaatttcttctactgatggaacgaaatggaggttaagaagtgac
agaaaaagtcttttcgacgtaaagacgttagcatattctctctacgatgtattttcagaa
aatgtaacccaagcagacccgtttgacgtccttattatggttactgcctacctaatgatg
ttctacaccatattcggcctcttcaatgacatgaggaagaccgggtcaaatttttggttg
agcgcctctacagtggtcaattctgcatcatcacttttcttagcattgtatgtcacccaa
tgtattctaggcaaagaagtttccgcattaactctttttgaaggtttgcctttcattgta
gttgttgttggtttcaagcacaaaatcaagattgcccagtatgccctggagaaatttgaa
agagtcggtttatctaaaaggattactaccgatgaaatcgtttttgaatccgtgagcgaa
gagggtggtcgtttgattcaagaccatttgctttgtatttttgcctttatcggatgctct
atgtatgctcaccaattgaagactttgacaaacttctgcatattatcagcatttatccta
atttttgaattgattttaactcctacattttattctgctatcttagcgcttagactggaa
atgaatgttatccacagatctactattatcaagcaaacattagaagaagacggtgttgtt
ccatctacagcaagaatcatttctaaagcagaaaagaaatccgtatcttctttcttaaat
ctcagtgtggttgtcattatcatgaaactctctgtcatactgttgtttgtcttcatcaac
ttttataactttggtgcaaattgggtcaatgatgccttcaattcattgtacttcgataag
gaacgtgtttctctaccagattttattacctcgaatgcctctgaaaactttaaagagcaa
gctattgttagtgtcaccccattattatattacaaacccattaagtcctaccaacgcatt
gaggatatggttcttctattgcttcgtaatgtcagtgttgccattcgtgataggttcgtc
agtaaattagttctttccgccttagtatgcagtgctgtcatcaatgtgtatttattgaat
gctgctagaattcataccagttatactgcagaccaattggtgaaaactgaagtcaccaag
aagtcttttactgctcctgtacaaaaggcttctacaccagttttaaccaataaaacagtc
atttctggatcgaaagtcaaaagtttatcatctgcgcaatcgagctcatcaggaccttca
tcatctagtgaggaagatgattcccgcgatattgaaagcttggataagaaaatacgtcct
ttagaagaattagaagcattattaagtagtggaaatacaaaacaattgaagaacaaagag
gtcgctgccttggttattcacggtaagttacctttgtacgctttggagaaaaaattaggt
gatactacgagagcggttgcggtacgtaggaaggctctttcaattttggcagaagctcct
gtattagcatctgatcgtttaccatataaaaattatgactacgaccgcgtatttggcgct
tgttgtgaaaatgttataggttacatgcctttgcccgttggtgttataggccccttggtt
atcgatggtacatcttatcatataccaatggcaactacagagggttgtttggtagcttct
gccatgcgtggctgtaaggcaatcaatgctggcggtggtgcaacaactgttttaactaag
gatggtatgacaagaggcccagtagtccgtttcccaactttgaaaagatctggtgcctgt
aagatatggttagactcagaagagggacaaaacgcaattaaaaaagcttttaactctaca
tcaagatttgcacgtctgcaacatattcaaacttgtctagcaggagatttactcttcatg
agatttagaacaactactggtgacgcaatgggtatgaatatgatttctaaaggtgtcgaa
tactcattaaagcaaatggtagaagagtatggctgggaagatatggaggttgtctccgtt
tctggtaactactgtaccgacaaaaaaccagctgccatcaactggatcgaaggtcgtggt
aagagtgtcgtcgcagaagctactattcctggtgatgttgtcagaaaagtgttaaaaagt
gatgtttccgcattggttgagttgaacattgctaagaatttggttggatctgcaatggct
gggtctgttggtggatttaacgcacatgcagctaatttagtgacagctgttttcttggca
ttaggacaagatcctgcacaaaatgttgaaagttccaactgtataacattgatgaaagaa
gtggacggtgatttgagaatttccgtatccatgccatccatcgaagtaggtaccatcggt
ggtggtactgttctagaaccacaaggtgccatgttggacttattaggtgtaagaggcccg
catgctaccgctcctggtaccaacgcacgtcaattagcaagaatagttgcctgtgccgtc
ttggcaggtgaattatccttatgtgctgccctagcagccggccatttggttcaaagtcat
atgacccacaacaggaaacctgctgaaccaacaaaacctaacaatttggacgccactgat
ataaatcgtttgaaagatgggtccgtcacctgcattaaatcctaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (54)   

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