KEGG   Saccharomyces cerevisiae (budding yeast): YBR084W
Entry
YBR084W           CDS       T00005                                 
Symbol
MIS1
Name
(RefSeq) trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
sce  Saccharomyces cerevisiae (budding yeast)
Pathway
sce00670  One carbon pool by folate
sce01100  Metabolic pathways
sce01240  Biosynthesis of cofactors
Module
sce_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:sce00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    YBR084W (MIS1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:sce04147]
    YBR084W (MIS1)
Enzymes [BR:sce01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     YBR084W (MIS1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     YBR084W (MIS1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     YBR084W (MIS1)
Exosome [BR:sce04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   YBR084W (MIS1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AlaDh_PNT_C HEM4 CREPT
Other DBs
NCBI-GeneID: 852378
NCBI-ProteinID: NP_009640
SGD: S000000288
UniProt: P09440
Position
II:411054..413981
AA seq 975 aa
MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKL
KHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDIN
DDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYG
CMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADI
VIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPV
PGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIK
QVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMG
LVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAA
NNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALT
PEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMA
ILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTP
VMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGER
FFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLV
KQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELA
HAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGN
LPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGY
MAVEVDDDGEIEGLF
NT seq 2928 nt   +upstreamnt  +downstreamnt
atgttgtcgagactatctttattgagtaactcgagggcgttccaacaggccagatggcgc
atttaccgcttaaaagtttcgccaactgtgcatgcttctcaataccatattctttctggt
aggaaacttgctcaatctattcgagaaaaagccaatgatgagatacaagccattaagctt
aagcatcctaatttcaagcctaccttgaaaatcattcaagtcggggccagaccagactca
tctacgtacgtgaggatgaaattgaaagcttcaaaggacagcaatgtagactgtatcata
gagaagttaccagcagaaatcactgaagttgagcttttgaagaaaattagtgacatcaat
gatgatgactctatccatgggttgctaattcaactacctctaccgcgtcacttggatgaa
accacgattacaaacgctgtggactttaaaaaggacgttgatgggttccacagatataat
gctggtgaattggctaaaaaaggagggaaaccatacttcataccatgtactccttatggt
tgcatgaaattacttgaagaagctcatgttaagttagatggtaagaacgccgtcgtgtta
ggcagatcaagtatcgtcggaaatccaattgcttcgttgttgaaaaatgcgaatgccact
gttactgtctgtcatagtcatacaaggaacattgcagaagtggtctcccaagctgatata
gttatcgcagcttgcggtattcctcaatacgttaaatcagactggattaaagaaggcgcc
gtggttattgatgtaggtatcaactacgtacctgatatcagtaagaaaagtgggcaaaaa
ttagttggtgatgttgattttgattctgtaaaggaaaagacatcttatattacccctgtt
cctggtggagtgggtccaatgactgtcgctatgcttgtttccaatgtactattagctgct
aaaaggcaattcgtggaatctgaaaagcttccagttatcaaacctcttccattacactta
gaaagtccagtgccttcagatattgatatatcaagagctcagagtcctaagcatatcaag
caagttgccgaggagttgggaatccactctcacgaattagaattatacggccactataag
gcaaaaatttctccaaatatttttaaaagattagaatctagagaaaacggtaagtacgtc
cttgttgcaggtattactccgactccattgggtgaaggtaaatccactacgactatgggg
ttggtgcaggctttatccgctcatttagggaaaccatccatcgcgaacgttagacaacca
tctcttggcccaaccctgggtgtcaaaggtggtgctgctggtggtggttatgcccaagtt
attcctatggacgagttcaatttacatttgaccggggatattcatgctatcagcgctgcg
aacaatcttcttgcagcagctatcgacactagaatgttccatgaagccactcagaagaat
gatagtacattttacaagagactagttccaagaaaaaaaggcatcagaaagtttacccca
tccatgcagagaaggcttaaaagattggatattgaaaaagaagaccctgatgctttaaca
cctgaagaagtcaaaagatttgctagattgaacataaatcccgatactatcactatcaga
agagttgtcgacatcaatgacaggatgttaagacaaattaccattggcgaagccgctacg
gagaagggttttacaaggaccactggattcgatatcactgttgcctctgaattaatggcc
attttagctctatctaaaagcttacacgagatgaaggaacgtattggacgcatggttatt
ggtgctgattatgataacaaaccagtaacagtagaagatattggctgtaccggtgctctg
actgcattattacgtgacgctataaagcctaacttaatgcaaactttggaagggaccccc
gtaatggttcacgctggtcctttcgccaacatctccatcggcgcatcatcagtaattgca
gacttaatggcattgaagcttgttggttcagaaaagaacccgttaaatgacaagaacatc
catgaacctggttatgtagttactgaagcaggattcgattttgccatgggtggtgaaaga
ttctttgatatcaaatgtcgttcctctggattggtgccagatgcagttgtcttagtcgca
accgtaagagctttgaaatctcatggaggtgctccaaatgttaagcccggacaatcatta
ccaaaagaatacacagaggaaaacatcgattttgttgccaagggtgttagtaatttggtt
aagcagattgaaaacatcaaaacgtttggaataccagtcgttgtagcaatcaacagattt
gaaacagactcacaggcagagattgaggtaatcaagaaagcagccttgaatgctggcgca
tctcatgccgttacttctaatcactggatggaaggtggtaaaggtgcagtagaattagca
catgctgtggtagatgcaacgaaagaaccaaagaactttaactttttgtacgacgtcaat
agctccatcgaggacaagcttaccagcatcgtccaaaaaatgtatggtggggcaaaaatc
gaagtatcaccagaagcccaaaaaaagatagacacctacaaaaaacaaggcttcggtaat
cttcccatctgtattgctaagacacaatattcattatcccatgatccatcattaaagggt
gttcctagaggttttacgttccccatcagggatgtgagagcttcaataggtgcaggttat
ttatacgctttggctgcagaaattcaaaccataccgggtctatcgacatatgctggttac
atggcagtagaagtcgacgacgacggtgaaattgaaggtctattttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (6)   
   Pfam (6)   
All databases (66)   

Download RDF
DBGET integrated database retrieval system