KEGG   Saccharomyces cerevisiae (budding yeast): YDR440W
Entry
YDR440W           CDS       T00005                                 
Symbol
DOT1, KMT4, PCH1
Name
(RefSeq) histone methyltransferase DOT1
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
sce  Saccharomyces cerevisiae (budding yeast)
Pathway
sce00310  Lysine degradation
sce01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:sce00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    YDR440W (DOT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:sce03036]
    YDR440W (DOT1)
Enzymes [BR:sce01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     YDR440W (DOT1)
Chromosome and associated proteins [BR:sce03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     YDR440W (DOT1)
   HMT complexes
    Dot1-containing complex
     YDR440W (DOT1)
SSDB
Motif
Pfam: DOT1 DUF3479
Other DBs
NCBI-GeneID: 852050
NCBI-ProteinID: NP_010728
SGD: S000002848
UniProt: Q04089
Structure
Position
IV:1342493..1344241
AA seq 582 aa
MGGQESISNNNSDSFIMSSPNLDSQESSISPIDEKKGTDMQTKSLSSYSKGTLLSKQVQN
LLEEANKYDPIYGSSLPRGFLRDRNTKGKDNGLVPLVEKVIPPIHKKTNNRNTRKKSSTT
TKKDVKKPKAAKVKGKNGRTNHKHTPISKQEIDTAREKKPLKKGRANKKNDRDSPSSTFV
DWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTNSPQPTSLTSDNDTSSVTTAKLQ
SILFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLPSPYAEQLKETILPDLNASF
DNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSFIHDFLHIVYTRSIHPQANK
LKHYKAFSNYVYGELLPNFLSDVYQQCQLKKGDTFMDLGSGVGNCVVQAALECGCALSFG
CEIMDDASDLTILQYEELKKRCKLYGMRLNNVEFSLKKSFVDNNRVAELIPQCDVILVNN
FLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLTYQINFYNVENIFNRLKVQRYDLKEDS
VSWTHSGGEYYISTVMEDVDESLFSPAARGRRNRGTPVKYTR
NT seq 1749 nt   +upstreamnt  +downstreamnt
atgggcggtcaagaaagtatatcaaataataactcagactcattcattatgtcgtccccc
aacttagactctcaggaatcttcaatatcacctattgatgagaagaaaggcaccgatatg
caaaccaagtcgctttcaagctattctaaaggtacgcttctctctaagcaagtacaaaat
ttattagaagaagctaataaatacgatccaatatatgggtcatctttacctcgaggattt
ttaagagatagaaacaccaagggtaaggataatgggttggttccgctggtggagaaggtt
atacctcccattcacaagaaaaccaataatagaaacacaaggaagaagtcatctaccacc
acgaagaaggatgtaaagaagccaaaagctgcaaaagtaaaaggaaaaaatggcaggact
aaccataaacataccccaatttcaaagcaagaaatagatactgcacgagaaaaaaagcca
ttgaaaaaaggtcgggcaaacaagaagaatgatcgcgatagtccttcatcaacatttgtt
gattggaatggcccgtgtctacggttacaatatccattatttgacatagagtacttaaga
tcacatgaaatatattctggaactcctatacaatccattagtttaagaacaaattctcca
cagccaacgagcttgacatcagataacgacacttcctcagtaacgacagcaaagttgcag
agtattttattttcaaattatatggaagagtacaaagtcgacttcaaaaggtcaacagcc
atttataatccaatgagtgaaattggtaaattaattgaatacagctgcctggtcttttta
ccttcaccttatgctgaacaattgaaggaaactatactaccggacctaaatgcatcattt
gataactctgacacgaaaggtttcgtgaatgctataaatttatacaacaaaatgattcgt
gaaattcctaggcaaagaataattgaccatttagaaacaattgataaaattcctcgttca
ttcattcatgacttcttgcatatcgtctataccaggagtatccatccgcaggcgaataaa
ttgaaacattacaaagcattcagcaattatgtttatggagaacttttgcccaatttccta
tctgatgtatatcaacaatgccagttgaagaagggtgacactttcatggatctcggttcg
ggagtaggtaattgcgtagtacaagctgcgttggaatgtggatgtgcattaagcttcgga
tgtgaaatcatggatgatgctagcgatttaactatactgcagtacgaggaactaaagaag
aggtgtaagttatatgggatgcgtttgaacaacgtggagttttcattgaagaaaagcttt
gtggacaataacagggtcgctgaactaattcctcagtgcgatgttatcctcgtaaataat
tttttatttgatgaagatttgaataaaaaagtcgaaaagatactacaaacggcaaaagtt
ggatgtaagatcataagtttgaaaagtttaagaagcctcacttatcagatcaacttctac
aatgttgagaacatcttcaatagattaaaggtgcaaaggtatgatcttaaggaggatagt
gtttcatggacgcatagtggcggagagtattatatatcaacagtgatggaggatgtggac
gaaagtttattcagccctgctgcaagaggtaggaggaacagaggtacgccggtgaagtat
accagatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (42)   

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