KEGG   Sarcophilus harrisii (Tasmanian devil): 100918445
Entry
100918445         CDS       T02286                                 
Symbol
TSC2
Name
(RefSeq) tuberin isoform X1
  KO
K07207  tuberous sclerosis 2
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr04072  Phospholipase D signaling pathway
shr04115  p53 signaling pathway
shr04140  Autophagy - animal
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04152  AMPK signaling pathway
shr04211  Longevity regulating pathway
shr04218  Cellular senescence
shr04714  Thermogenesis
shr04910  Insulin signaling pathway
shr04919  Thyroid hormone signaling pathway
shr05163  Human cytomegalovirus infection
shr05165  Human papillomavirus infection
shr05168  Herpes simplex virus 1 infection
shr05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    100918445 (TSC2)
   04151 PI3K-Akt signaling pathway
    100918445 (TSC2)
   04152 AMPK signaling pathway
    100918445 (TSC2)
   04150 mTOR signaling pathway
    100918445 (TSC2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100918445 (TSC2)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100918445 (TSC2)
   04218 Cellular senescence
    100918445 (TSC2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100918445 (TSC2)
   04919 Thyroid hormone signaling pathway
    100918445 (TSC2)
  09149 Aging
   04211 Longevity regulating pathway
    100918445 (TSC2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100918445 (TSC2)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    100918445 (TSC2)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    100918445 (TSC2)
   05163 Human cytomegalovirus infection
    100918445 (TSC2)
   05165 Human papillomavirus infection
    100918445 (TSC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:shr01009]
    100918445 (TSC2)
Protein phosphatases and associated proteins [BR:shr01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     100918445 (TSC2)
SSDB
Motif
Pfam: Tuberin DUF3384 Rap_GAP ERAP1_C Cnd1
Other DBs
NCBI-GeneID: 100918445
NCBI-ProteinID: XP_031801697
Ensembl: ENSSHAG00000015973
Position
1:345736923..345796867
AA seq 1843 aa
MAKPPSKDSGLKEKFRTLLGLGTSRLPRSSEGKQTEFIITAEILKELSVECGLSNRIRTI
GHICEAAKTKKFEEHAVEAIWRAVADMLQPERPAEARHAVLYLLKAIIQGQGERLGVLRA
HLFKVIKNYPSNEDLHERLEVFKALTDNGRYITYLEEELADFVLQWMDIGLSSEFLLVLV
NLVKFNSCYLDEYIASMVRMICLLCIRTASSVDIEVSLQVLDAVVCYNCLPSESLPVFII
TLCRTINVKELCEPCWKLMRNLLGTHLGHSAICNMCRIMEDRAYMEDAPLLRGAVFFVGM
ALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSVTRLVKKYRKELQAVTWDIL
LKIIERLLQQLQSIESQELKTIVHDLLTTVEELCDQNEFHGSEERFFELVERCADQRPES
SLLNLITYRAQSIHPAKDGWIHNLQLLMERFFSKLHSFALAFPFRNETRSAVRIKVLDVL
SFVLSINSQFYEEELINMVVISQLAHIPEDKDHQVRKLATQLLVDLAECCHTHHFNSLLD
IIEKVIARSLSPPPELEDRDLASYSASLEDVKTAVLGLLVILQTKLYTLPASHASRVYEM
LVNHIQLHYKHMYRLPIASSIRLKAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCLCDNI
EPERGSEKKASGGTLSPPTGPASIAAQGASVRLGYLPYSRFFGVLLQCLKQETDWKVLKL
VLSKLPESLRYKVLIFTSSCNVDQLSSALCSMLSDKKTPERLCGTPDGFSRTDLHLAVVP
VLTALISYHNYLDKTKQREMVYCLEHGLIYRCANQCVVALSVCSVEMPDVIIKALPVLIV
KLTHISATANMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCL
AHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSSL
RIAKPPKQGLNNSPPVKEFKESSAVDAFRSRSISVSEHVVRSRIQTSITSSSLGSADENS
MAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLI
TVTTSVGTGTRSLLGLDSGELQNTEASTDPNLQVRQTKEAPAKLESQAGQQVCRGSRDRV
RSMSGGHALRGNTLDTSTSHFPSSPASPGLQSTPTARTEKASASGQTPLQKGKTNLAAYV
PLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRET
ALYKSLSVPSSSLTTGTDKPSLLQRSNTVASFSSMYQSSCQGKLHRSVSWAESAVVLEEG
SQTEVGLRETDSPSESQEIDDFEAIGSQTTASDERFGKLPDVYSRSSSTSSQEEKSFRSE
ELITGGIPIERAVSSEDGRPIADHSFQPSQPLSKSSSSPELQTLQDVLKDAEDKGHLGKL
SIEIKAKSQSGNLEGEATNTWPSPGEESRGLGAGRQEAATPSSSSPRSPSGLRPRGYTIS
DSAPSRRGKKMEKDAFKSRAATSNTEKVPGINPSFVFLQLYHSPFFGDESNKPLLLPPET
FEKSVQLLDQIPSYDTHKIAVLYVGEGQSNSEIAILSNEHGSYRYTEFLTGLGKLIELKD
CQPDKIYLGGLDVCGEDGQFTYCWHDDIMQAIFHIATLMPTKDLDKYRCDKKRHLGNDFV
SIIYNDSGEDFKLGTIKGQFNFVHVIITPLDYECNLVTLQCRKDMEGLVDTSVAKIVSDQ
NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRHRIREETQYPNSGFP
LMQMHPPAHPKSPPQAPSDSTPTYETGQRKRLISSVDDFTEFV
NT seq 5532 nt   +upstreamnt  +downstreamnt
atggctaaaccaccgagcaaagattctgggctaaaggagaaattcaggactctgttgggg
ctgggaacatcaagacttcctagatcttctgaggggaagcaaactgagtttatcatcact
gctgaaattctgaaggaactcagcgtagagtgtggcttgagcaatcggattcggacaata
ggtcatatttgtgaagcagcaaaaaccaagaaatttgaagagcatgcagtagaagctatc
tggagagctgtagctgacatgttacagccagagaggccagcagaagctcggcatgctgtt
ctgtatcttctgaaggccattattcagggtcagggggaacgcttgggtgttctcagagca
cacctgtttaaggtaatcaaaaattacccctccaatgaagacctgcatgagagacttgaa
gttttcaaggctctcactgacaatgggagatacatcacatatttggaagaagaactggct
gactttgtcctacaatggatggatattggcttatcatcagaatttcttctagtgcttgtg
aacctggtcaaatttaatagctgttacctagatgaatatattgcttcaatggttcgcatg
atctgtttgctctgcattcgtactgcatcttctgtggacatagaggtctccttgcaagtc
ctagatgctgttgtatgttataattgccttccctcggagagcctccctgtgtttattatc
acactatgccggaccattaatgtcaaagagctctgtgaaccttgctggaagcttatgcgc
aatcttttgggaacccatttgggccacagtgccatatgcaacatgtgtcgtatcatggag
gacagagcctacatggaagatgcccctttgctgagaggagcagtattctttgttgggatg
gctctttggggagctcacagactatattcactcaagaactcacctacatcagtgttgcct
tctttttatgaggccatgacttgtcccaatgaagtggtatcatatgagattgtcctgtct
gtaaccagacttgtgaagaagtacagaaaggagctacaagctgtcacatgggacattctt
ctaaagattattgagcgacttctacagcaattgcagagtatagagagccaagagctcaaa
actattgttcatgatttgttgactactgtggaagagctctgtgatcagaatgaattccat
ggctcagaggaaagattctttgaacttgttgagagatgtgctgatcagcgacctgaatcc
tcccttttaaacttaataacgtatagagctcagtcaattcatcctgctaaggatggctgg
attcataatttacagttactaatggagagattcttcagtaaacttcattcctttgcactt
gcttttcccttcaggaatgagacccgcagtgctgtgcgcattaaagtactggatgttttg
tcctttgttctgagcattaacagccagttttatgaggaggaactgattaacatggtagtc
atctcacaactagctcacattcctgaggataaagaccaccaagtccgaaaactagctact
cagctgctggtggacctggcagaatgctgtcatactcatcactttaacagtttgctggat
atcattgaaaaggtaattgcacgttcactttctcctcctcctgaattggaagaccgggac
ttagcttcatattcagcttccttagaagatgtgaaaactgctgtacttggtcttctggtt
atccttcagaccaaactctataccttgccggccagtcatgcctccagagtgtatgagatg
ctggtcaatcacattcagctgcattataagcacatgtataggcttccaatagccagcagc
atcaggcttaaggcctttgacttcttgctactgctccgagctgattcactccatcgtctt
ggccttcccaataaagatggtgttgtgagatttagcccctattgcctctgtgacaacata
gaacctgagagaggctctgagaagaaggccagtggtggtactctgtctccacccacgggg
cctgccagcattgctgcacaaggtgcatctgtccgcttgggctatttgccctattctcgg
ttctttggggtgctactgcagtgtttgaagcaggagactgactggaaagtattgaaactg
gttcttagtaagctgcctgagtccctccgatataaagttctcattttcacttcttcttgc
aatgtagatcagctctcctctgctctctgctcaatgctttcagataaaaagactcctgag
cgactctgtggcactcctgatggcttctctcgaacagacttacacttggcagtggttcca
gtgctgacagcattgatttcttaccataattatctggataaaactaaacagcgggagatg
gtgtattgcctggagcatggcctcatttaccggtgtgctaatcaatgtgttgtggcactg
tcagtgtgcagtgtagaaatgccagatgtcatcatcaaagcattgccagtcctgattgta
aagctcacccacatttctgcaacagccaacatggctatcccgctcttggaattcctttcc
actttagccagattgcctcatctctacaggaattttgctgctgagcagtatgcaagtgtg
tttgccatctccctgccatacacaaacccttctaaattcaatcaatatattgtatgtctg
gctcatcatgttatagccatgtggttcatcagatgtcgcttgccctttcgaaaagacttt
gttccctacatcaccaagggtttacgctccaatgttcttctgtcttttgatgacacccct
gaaaaggatagcttcagagctcggagtacaagccttaatgagaggcccaaaagtagttta
aggatagccaaaccccccaagcaaggcttgaataactctcctcccgtgaaggaattcaaa
gagagctctgcagttgatgccttccggtcccgcagcatcagtgtgtctgaacatgtggtt
cgcagcaggatacagacgtccatcactagctctagtttgggctctgcagatgagaattca
atggctcaggctgatgataacctaaaaaaccttcacctggaactcacagaaacttgcttg
gatatgatggccagatatgtcttttccaatttcacagctgtacccaaaagatctcctgtg
ggagaatttcttcttgctggagggagaaccaaaacctggttggttggaaacaagctaatc
actgtaacaacaagtgttgggactgggaccaggtccctgctaggcctggattctggggag
cttcagaatactgaagcaagcacagatcccaatttgcaagtgagacagacaaaggaagca
ccagccaagttagagtcccaggctggccagcaagtttgccggggatctcgagaccgtgta
cggtctatgtcaggaggtcatgctctccggggcaataccttggacacttcaacctcccac
ttcccaagcagtcctgcttctccagggttacagagtacacccactgctcggacggagaag
gcttcggccagtggccagactcctttacagaagggaaagaccaacttggctgcctatgta
cccctcctcacccagggctgggctgagatcctggtccggaggcccacagggaataccagc
tggctgatgagcttagaaaaccctctaagtccattctcttcagatatcaacaacatgccc
ctacaggagctatcgaatgcattaatggcagctgaacgttttaaagagcaccgggagaca
gcactgtataagtccttgtcagtgccatcctctagtctcaccacagggacagacaagcct
tctctcctacagcgttccaatacagtggcctctttctcttccatgtaccagtccagttgt
caaggaaagttgcataggagcgtttcctgggcagaatctgcagttgtccttgaagaagga
agccaaactgaagtgggcttgagagagacagattcaccatctgaatctcaagagatagac
gattttgaagccattggctctcagacaactgcaagtgatgagaggttcggcaaacttccg
gatgtttatagtaggtcctcttccacttcaagtcaagaagagaaatccttccgttctgaa
gagctcattacaggggggattcccattgagagagctgtctcttctgaagatggcaggccc
atagctgatcactccttccagccttctcagcctctgagcaagtccagctcttctcctgag
ttacagaccctgcaggatgtcctcaaggatgctgaggataaaggacaccttgggaagctg
agcatagaaatcaaagccaagtcccagtcggggaatttagaaggggaagccaccaacacc
tggccaagtccgggggaggagagccgaggccttggtgcaggccggcaagaggctgcaaca
ccatcttcaagctcacctcgttccccaagtggcctccgacctcggggctacaccatctct
gattcagccccgtcaaggagaggcaagaagatggagaaggatgccttcaagagtagagct
gccacatccaacacagagaaggtgcccgggataaaccccagttttgtattcctgcagctc
taccattcccctttctttggagatgagtccaacaagccactcctgttgcctcctgagaca
ttcgaaaaatctgtgcagctcctagatcagattccttcttatgatacccacaagattgct
gtcctgtatgttggagaaggccagagcaacagtgagattgccatcctctccaatgagcat
ggatcctataggtacacagaattcttgacaggcttggggaagctcattgaactcaaagat
tgccagccagacaagatctacctgggaggcctggatgtgtgtggagaggatgggcagttc
acctactgttggcacgatgatatcatgcaagctatctttcacatcgccactctgatgccc
accaaagacttagataaataccgctgtgacaagaagaggcacctagggaatgactttgtg
tcaattatctacaatgattctggagaagacttcaaactgggtactatcaagggccagttc
aactttgtacatgtgataatcactcccctggattatgaatgcaacttggtcacgctgcaa
tgtcggaaagatatggaaggccttgtggacaccagtgtggctaaaattgtatcagaccaa
aatcttccctttgttgcccgccagatggcattgcacgcgaatatggcatcccaagtccat
cacagcaggtcaaaccctacagacatttacccctccaaatggatcgccagattacgccac
atcaaacggcttcggcacaggatccgggaagaaacccagtacccgaactctggcttcccc
ttgatgcagatgcacccaccagctcatcccaagtccccgccccaagctccttcagactcc
acgcccacctatgagacaggccagaggaaacggctcatctcttctgtggacgacttcaca
gagtttgtgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (15)   
   KEGG PATHWAY (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   RefSeq(pep) (11)   
DNA sequence (11)   
   RefSeq(nuc) (11)   
Protein domain (5)   
   Pfam (5)   
All databases (71)   

Download RDF
DBGET integrated database retrieval system