KEGG   Sarcophilus harrisii (Tasmanian devil): 100932099
Entry
100932099         CDS       T02286                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00562  Inositol phosphate metabolism
shr01100  Metabolic pathways
shr01521  EGFR tyrosine kinase inhibitor resistance
shr01522  Endocrine resistance
shr01524  Platinum drug resistance
shr04012  ErbB signaling pathway
shr04014  Ras signaling pathway
shr04015  Rap1 signaling pathway
shr04024  cAMP signaling pathway
shr04062  Chemokine signaling pathway
shr04066  HIF-1 signaling pathway
shr04068  FoxO signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04071  Sphingolipid signaling pathway
shr04072  Phospholipase D signaling pathway
shr04140  Autophagy - animal
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04152  AMPK signaling pathway
shr04210  Apoptosis
shr04211  Longevity regulating pathway
shr04213  Longevity regulating pathway - multiple species
shr04218  Cellular senescence
shr04360  Axon guidance
shr04370  VEGF signaling pathway
shr04380  Osteoclast differentiation
shr04510  Focal adhesion
shr04550  Signaling pathways regulating pluripotency of stem cells
shr04611  Platelet activation
shr04613  Neutrophil extracellular trap formation
shr04620  Toll-like receptor signaling pathway
shr04625  C-type lectin receptor signaling pathway
shr04630  JAK-STAT signaling pathway
shr04650  Natural killer cell mediated cytotoxicity
shr04660  T cell receptor signaling pathway
shr04662  B cell receptor signaling pathway
shr04664  Fc epsilon RI signaling pathway
shr04666  Fc gamma R-mediated phagocytosis
shr04668  TNF signaling pathway
shr04670  Leukocyte transendothelial migration
shr04722  Neurotrophin signaling pathway
shr04725  Cholinergic synapse
shr04750  Inflammatory mediator regulation of TRP channels
shr04810  Regulation of actin cytoskeleton
shr04910  Insulin signaling pathway
shr04914  Progesterone-mediated oocyte maturation
shr04915  Estrogen signaling pathway
shr04917  Prolactin signaling pathway
shr04919  Thyroid hormone signaling pathway
shr04923  Regulation of lipolysis in adipocytes
shr04926  Relaxin signaling pathway
shr04929  GnRH secretion
shr04930  Type II diabetes mellitus
shr04931  Insulin resistance
shr04932  Non-alcoholic fatty liver disease
shr04933  AGE-RAGE signaling pathway in diabetic complications
shr04935  Growth hormone synthesis, secretion and action
shr04960  Aldosterone-regulated sodium reabsorption
shr04973  Carbohydrate digestion and absorption
shr05010  Alzheimer disease
shr05017  Spinocerebellar ataxia
shr05020  Prion disease
shr05100  Bacterial invasion of epithelial cells
shr05132  Salmonella infection
shr05135  Yersinia infection
shr05142  Chagas disease
shr05146  Amoebiasis
shr05160  Hepatitis C
shr05161  Hepatitis B
shr05162  Measles
shr05163  Human cytomegalovirus infection
shr05164  Influenza A
shr05165  Human papillomavirus infection
shr05166  Human T-cell leukemia virus 1 infection
shr05167  Kaposi sarcoma-associated herpesvirus infection
shr05168  Herpes simplex virus 1 infection
shr05169  Epstein-Barr virus infection
shr05170  Human immunodeficiency virus 1 infection
shr05171  Coronavirus disease - COVID-19
shr05200  Pathways in cancer
shr05203  Viral carcinogenesis
shr05205  Proteoglycans in cancer
shr05206  MicroRNAs in cancer
shr05207  Chemical carcinogenesis - receptor activation
shr05208  Chemical carcinogenesis - reactive oxygen species
shr05210  Colorectal cancer
shr05211  Renal cell carcinoma
shr05212  Pancreatic cancer
shr05213  Endometrial cancer
shr05214  Glioma
shr05215  Prostate cancer
shr05218  Melanoma
shr05220  Chronic myeloid leukemia
shr05221  Acute myeloid leukemia
shr05222  Small cell lung cancer
shr05223  Non-small cell lung cancer
shr05224  Breast cancer
shr05225  Hepatocellular carcinoma
shr05226  Gastric cancer
shr05230  Central carbon metabolism in cancer
shr05231  Choline metabolism in cancer
shr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
shr05415  Diabetic cardiomyopathy
shr05417  Lipid and atherosclerosis
shr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100932099 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100932099 (PIK3CA)
   04014 Ras signaling pathway
    100932099 (PIK3CA)
   04015 Rap1 signaling pathway
    100932099 (PIK3CA)
   04370 VEGF signaling pathway
    100932099 (PIK3CA)
   04630 JAK-STAT signaling pathway
    100932099 (PIK3CA)
   04668 TNF signaling pathway
    100932099 (PIK3CA)
   04066 HIF-1 signaling pathway
    100932099 (PIK3CA)
   04068 FoxO signaling pathway
    100932099 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100932099 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100932099 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100932099 (PIK3CA)
   04024 cAMP signaling pathway
    100932099 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100932099 (PIK3CA)
   04152 AMPK signaling pathway
    100932099 (PIK3CA)
   04150 mTOR signaling pathway
    100932099 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100932099 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    100932099 (PIK3CA)
   04218 Cellular senescence
    100932099 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100932099 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100932099 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100932099 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100932099 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    100932099 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100932099 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    100932099 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100932099 (PIK3CA)
   04660 T cell receptor signaling pathway
    100932099 (PIK3CA)
   04662 B cell receptor signaling pathway
    100932099 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100932099 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100932099 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100932099 (PIK3CA)
   04062 Chemokine signaling pathway
    100932099 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100932099 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    100932099 (PIK3CA)
   04929 GnRH secretion
    100932099 (PIK3CA)
   04915 Estrogen signaling pathway
    100932099 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100932099 (PIK3CA)
   04917 Prolactin signaling pathway
    100932099 (PIK3CA)
   04926 Relaxin signaling pathway
    100932099 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    100932099 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100932099 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100932099 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100932099 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    100932099 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100932099 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100932099 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    100932099 (PIK3CA)
   04380 Osteoclast differentiation
    100932099 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    100932099 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100932099 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100932099 (PIK3CA)
   05206 MicroRNAs in cancer
    100932099 (PIK3CA)
   05205 Proteoglycans in cancer
    100932099 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    100932099 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    100932099 (PIK3CA)
   05203 Viral carcinogenesis
    100932099 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100932099 (PIK3CA)
   05231 Choline metabolism in cancer
    100932099 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100932099 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100932099 (PIK3CA)
   05212 Pancreatic cancer
    100932099 (PIK3CA)
   05225 Hepatocellular carcinoma
    100932099 (PIK3CA)
   05226 Gastric cancer
    100932099 (PIK3CA)
   05214 Glioma
    100932099 (PIK3CA)
   05221 Acute myeloid leukemia
    100932099 (PIK3CA)
   05220 Chronic myeloid leukemia
    100932099 (PIK3CA)
   05218 Melanoma
    100932099 (PIK3CA)
   05211 Renal cell carcinoma
    100932099 (PIK3CA)
   05215 Prostate cancer
    100932099 (PIK3CA)
   05213 Endometrial cancer
    100932099 (PIK3CA)
   05224 Breast cancer
    100932099 (PIK3CA)
   05222 Small cell lung cancer
    100932099 (PIK3CA)
   05223 Non-small cell lung cancer
    100932099 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100932099 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    100932099 (PIK3CA)
   05161 Hepatitis B
    100932099 (PIK3CA)
   05160 Hepatitis C
    100932099 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    100932099 (PIK3CA)
   05164 Influenza A
    100932099 (PIK3CA)
   05162 Measles
    100932099 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    100932099 (PIK3CA)
   05163 Human cytomegalovirus infection
    100932099 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100932099 (PIK3CA)
   05169 Epstein-Barr virus infection
    100932099 (PIK3CA)
   05165 Human papillomavirus infection
    100932099 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100932099 (PIK3CA)
   05135 Yersinia infection
    100932099 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    100932099 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100932099 (PIK3CA)
   05142 Chagas disease
    100932099 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100932099 (PIK3CA)
   05017 Spinocerebellar ataxia
    100932099 (PIK3CA)
   05020 Prion disease
    100932099 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100932099 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    100932099 (PIK3CA)
   05415 Diabetic cardiomyopathy
    100932099 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100932099 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    100932099 (PIK3CA)
   04931 Insulin resistance
    100932099 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100932099 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100932099 (PIK3CA)
   01524 Platinum drug resistance
    100932099 (PIK3CA)
   01522 Endocrine resistance
    100932099 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shr04131]
    100932099 (PIK3CA)
Enzymes [BR:shr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100932099 (PIK3CA)
Membrane trafficking [BR:shr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100932099 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 100932099
NCBI-ProteinID: XP_031813556
Ensembl: ENSSHAG00000016406
Position
3:36715127..36801227
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYSKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASTKSLWGVNSALRIRILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SNPVKFPDMSVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVNIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaattatggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactacctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacatgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagtgttactcaagaagcagaaagagaa
gaattttttgatgaaacacggcgactttgtgacctgcggctttttcagccctttctgaaa
gtcatcgaacctgtaggaaaccgagaagaaaaaattctcaatcgagaaatcggttttgct
attggtatgcctgtttgtgaatttgacatggttaaagatccagaagtgcaagacttccga
agaaatattcttaatgtttgtaaagaagctgtggacctgagggatgtccatgcaccccat
agtagagcattatatgtttatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatacagtaaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aacaatgacaagcaaaagtacactttaaaaatcaatcacgactgtgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacacggagtatgttactatcatctgagcagctgaag
ctctgtgttttagagtatcagggcaaatatattttaaaagtgtgtggatgtgatgagtat
ttgctagaaaaatatcctcttagccaatataagtacataagaagctgtataatgcttggt
cggatgcccaatctgatgctgatggctaaagaaagtctttacacccagctaccactggat
acttttacaatgccatcttattccaggcgaatctctacagccacaccgtacatgaatgga
gaagcttcaaccaaatccctttggggcgtaaatagtgcactccgcataagaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgacaagatctatgttagaacaggtatt
tgccatgggggtgagccattatgtgacaatgtgaatactcagagagtaccttgttccaat
cccaggtggaatgaatggctaatgtatgatatatacattcccgatcttccacgtgctgct
cgactttgcctttccatttgttctgttaaaggcaggaaaggagcaaaagaggaacattgc
ccattggcttggggaaatattaacctctttgattatacagacactctggtatcaggaaaa
atggctttgaatctgtggccagtacctcatggattagaagacttgctgaatcctattgga
gttactggatcaaatcccaataaggaaactccatgtttagagctggaatttgactggttt
agcaatcctgtaaagttcccagatatgtcagtaattgaagaacatgcaaattggactgta
tctcgagaactaggattcaactattcccatgctggactgagtaataggatagctcgagat
aatgaattgagagaaaatgacaaagaacagctccgggcgatttgtacacgagaccctctg
tctgagatcactgagcaagaaaaggacttcctgtggagtcataggcattattgtgtcaat
ataccagaaattctacctaaactacttctgtctgttaagtggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcccccaatcaaaccagaacaggccatggaa
cttttggactgtaattatccagaccctatggttcgagcttttgctgttcgatgcttggag
aaatatttaactgatgacaaactttctcaatacttaattcaactggttcaggttctgaag
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggatagggcactttttcttttggcatttaaagtctgaaatgcataataaaactgtc
agccagagatttggtttgcttttggagtcatactgtcgagcatgtgggatgtatctaaag
catctgaatcggcaggtagaggccatggagaaactgatcaacctcaccgacattctcaaa
caggagaagaaggatgagacacaaaaggtacagatgaagttcttggttgagcaaatgaga
cgacctgattacatggatgctttacaaggctttatctctccccttaaccctgctcatcaa
ctaggaaatctcaggctcgaagagtgtaggattatgtcttccgcaaaaagaccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactatttcagaacaatgagatcatc
tttaaaaatggggatgacttacggcaggatatgctaacccttcagatcattcggattatg
gaaaatatctggcaaaatcagggtcttgatcttcggatgttaccttatggttgtctatca
atcggggactgtgttggcctcattgaggtggtcagaaattcccacactatcatgcagatt
cagtgtaaagggggcctgaaaggggccttgcagttcaacagccatacgttacatcagtgg
ctcaaagacaagaataaaggagaaatatatgatgcagccattgatttgtttacacgttcc
tgtgctggatactgtgtggctaccttcattttgggaattggtgatcgacacaatagcaat
atcatggtgaaagatgatggacaactattccacatagactttggacactttttggatcac
aagaagaagaaatttggctataaacgagagcgtgtgcccttcgtcttgacgcaagatttc
ttaattgtgattagtaaaggagcccaagaatgtacaaagacaagagagtttgagaggttt
caggaaatgtgctataaggcttacttagctattcgacaacatgccaatctcttcatcaat
ctcttctccatgatgcttggctccggaatgcccgaacttcagtcttttgacgacatcgcc
tatattcgaaagaccctggccttggataagactgagcaggaggctttggagtatttcatg
aagcagatgaatgatgctcatcatgggggctggacaaccaaaatggattggattttccat
acgataaagcagcacgctttgaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (8)   
   Pfam (8)   
All databases (144)   

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