KEGG   Streptococcus pyogenes M1 476 (serotype M1): M1GAS476_0049
Entry
M1GAS476_0049     CDS       T02499                                 
Symbol
purH
Name
(GenBank) bifunctional phosphoribosylaminoimidazolecarboxamideformyl transferase/IMP cyclohydrolase
  KO
K00602  phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
Organism
spym  Streptococcus pyogenes M1 476 (serotype M1)
Pathway
spym00230  Purine metabolism
spym00670  One carbon pool by folate
spym01100  Metabolic pathways
spym01110  Biosynthesis of secondary metabolites
Module
spym_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:spym00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    M1GAS476_0049 (purH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    M1GAS476_0049 (purH)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:spym04147]
    M1GAS476_0049 (purH)
Enzymes [BR:spym01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.3  phosphoribosylaminoimidazolecarboxamide formyltransferase
     M1GAS476_0049 (purH)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.10  IMP cyclohydrolase
     M1GAS476_0049 (purH)
Exosome [BR:spym04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   M1GAS476_0049 (purH)
SSDB
Motif
Pfam: AICARFT_IMPCHas MGS
Other DBs
NCBI-ProteinID: BAM29406
UniProt: J7M124
Position
1:38135..39682
AA seq 515 aa
MTKRALISVSDKSGIVDFAKELKNLGWDIISTGGTKVTLDDAGVETIAIDDVTRFPEMMD
GRVKTLHPNIHGGLLARRDADSHLQAAKDNNIELIDLVVVNLYPFKETILRPDITYDLAV
ENIDIGGPSMLRSAAKNHASVTVVVDPADYATVLGELADAGQTTFETRQRLAAKVFRHTA
AYDALIAEYFTTQVGEAKPEKLTITYDLKQAMRYGENPQQDADFYQKALPTDYSIASAKQ
LNGKELSFNNIRDADAAIRIIRDFKDRPTVVALKHMNPCGIGQADDIETAWDYTYKADPV
SIFGGIIVLNREVDAATAKKMHPIFLEIIIAPSYSEEALAILTNKKKNLRILELPFDAQA
ASEVEAEYTGVVGGLLVQNQDVVAENPSDWQVVTDRQPTEQEATALEFAWKAIKYVKSNG
IIITNDHMTLGLGAGQTNRVGSVKIAIEQAKDHLDGAVLASDAFFPFADNIEEIAAAGIK
AIIQPGGSVRDQDSIDAANKHGLTMIFTGVRHFRH
NT seq 1548 nt   +upstreamnt  +downstreamnt
atgactaaacgtgctttaatctcagtgtctgacaagtcaggaattgttgactttgcaaaa
gaattgaaaaacttgggttgggatattatctcaactggtgggactaaggttacccttgac
gatgctggtgttgagaccattgccatcgacgatgtgactagattcccagagatgatggac
ggtcgtgttaagaccctccacccaaacattcacggtgggcttttggctcgtcgcgacgct
gacagccaccttcaggctgctaaggacaacaatatcgagctgattgacctcgtggttgtc
aacctctatcccttcaaggagactatccttcgtccagacataacctatgatttggcggtg
gaaaacatcgacatcggcggtccatcaatgcttcgctcagccgctaaaaatcacgctagc
gtgaccgttgtggttgacccagcggattatgcgactgttttgggagaattggctgacgct
ggtcagacgacatttgaaacgcgtcaacgcttggcagctaaggtctttcgtcacacagca
gcctacgacgctttgattgctgagtacttcacaactcaagtgggagaggctaagcctgaa
aaattaaccatcacttacgaccttaaacaggctatgcgttacggagaaaatccacaacaa
gacgctgatttctatcaaaaagccttgccaacagactactcaattgcttctgctaaacag
ctcaacggaaaagaattgtctttcaataatatccgtgatgccgatgcggcaatccgtatt
atccgcgatttcaaagaccgtccaactgttgttgctctcaaacacatgaacccatgtggt
atcggacaggctgatgacattgagactgcttgggattacacttataaagctgacccagtt
tcaatctttggcggaattattgtccttaaccgtgaagttgacgcagcgacagccaagaag
atgcaccctatcttcttggaaatcatcatcgcaccatcatactcagaagaagcgctagct
attctcacaaataaaaagaaaaacttgcgaatccttgagttgccgtttgatgcccaagct
gccagcgaagtggaagctgagtacactggcgtagttggtggacttttggtgcaaaaccaa
gacgttgtggctgaaaatccatctgactggcaagtggtgacagaccgccaaccaacagaa
caagaggcgactgcccttgagtttgcctggaaggctatcaagtatgttaagtctaacggg
attattattactaacgatcacatgacgcttggactcggtgcaggtcaaaccaaccgtgtc
ggctcagtcaagattgctatcgagcaggctaaagaccaccttgacggtgccgttctagca
tcagatgccttcttcccatttgcggacaacattgaagaaatcgctgccgcagggatcaaa
gcaatcatccaaccaggtggttcagttcgtgaccaagactctattgacgccgcaaacaaa
catggcttgaccatgatcttcacaggtgtgagacattttaggcattaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (2)   
   Pfam (2)   
All databases (25)   

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