KEGG   Sus scrofa (pig): 100525505Help
Entry
100525505         CDS       T01009                                 

Gene name
MAP2K2
Definition
mitogen-activated protein kinase kinase 2
Orthology
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
ssc  Sus scrofa (pig)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100525505 (MAP2K2)
   04015 Rap1 signaling pathway
    100525505 (MAP2K2)
   04010 MAPK signaling pathway
    100525505 (MAP2K2)
   04012 ErbB signaling pathway
    100525505 (MAP2K2)
   04370 VEGF signaling pathway
    100525505 (MAP2K2)
   04066 HIF-1 signaling pathway
    100525505 (MAP2K2)
   04068 FoxO signaling pathway
    100525505 (MAP2K2)
   04024 cAMP signaling pathway
    100525505 (MAP2K2)
   04022 cGMP - PKG signaling pathway
    100525505 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    100525505 (MAP2K2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100525505 (MAP2K2)
  Cellular commiunity
   04540 Gap junction
    100525505 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100525505 (MAP2K2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    100525505 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    100525505 (MAP2K2)
   04660 T cell receptor signaling pathway
    100525505 (MAP2K2)
   04662 B cell receptor signaling pathway
    100525505 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    100525505 (MAP2K2)
  Endocrine system
   04910 Insulin signaling pathway
    100525505 (MAP2K2)
   04912 GnRH signaling pathway
    100525505 (MAP2K2)
   04915 Estrogen signaling pathway
    100525505 (MAP2K2)
   04917 Prolactin signaling pathway
    100525505 (MAP2K2)
   04921 Oxytocin signaling pathway
    100525505 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    100525505 (MAP2K2)
   04916 Melanogenesis
    100525505 (MAP2K2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    100525505 (MAP2K2)
  Nervous system
   04720 Long-term potentiation
    100525505 (MAP2K2)
   04730 Long-term depression
    100525505 (MAP2K2)
   04722 Neurotrophin signaling pathway
    100525505 (MAP2K2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100525505 (MAP2K2)
   05206 MicroRNAs in cancer
    100525505 (MAP2K2)
   05205 Proteoglycans in cancer
    100525505 (MAP2K2)
   05214 Glioma
    100525505 (MAP2K2)
   05216 Thyroid cancer
    100525505 (MAP2K2)
   05221 Acute myeloid leukemia
    100525505 (MAP2K2)
   05220 Chronic myeloid leukemia
    100525505 (MAP2K2)
   05218 Melanoma
    100525505 (MAP2K2)
   05211 Renal cell carcinoma
    100525505 (MAP2K2)
   05219 Bladder cancer
    100525505 (MAP2K2)
   05215 Prostate cancer
    100525505 (MAP2K2)
   05213 Endometrial cancer
    100525505 (MAP2K2)
   05223 Non-small cell lung cancer
    100525505 (MAP2K2)
  Neurodegenerative diseases
   05020 Prion diseases
    100525505 (MAP2K2)
  Infectious diseases
   05164 Influenza A
    100525505 (MAP2K2)
   05161 Hepatitis B
    100525505 (MAP2K2)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100525505 (MAP2K2)
Protein kinases [BR:ssc01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   100525505 (MAP2K2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Vega: 
UniProt: 
Position
2
AA seq 400 aa AA seqDB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGGDGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggatctccagaagaag
ctagaggagctagaactcgacgagcagcagaagaagcggctagaagcctttctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaaaggatctcggagctgggagcc
gggaacggcggagtggtcaccaaggtccagcacagaccctcaggcctcatcatggcaaga
aagctgatccacttggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtactgcacgagtgtaactccccctacatcgtgggcttctatggggccttctacagtgac
ggggagatcagtatctgcatggagcacatggatggcggctccctggaccaggtgttgaaa
gaagccaagagaattcctgaggaaatcctggggaaggtcagcatcgcggttctgcggggc
ctggcatatctccgggaaaagcaccagatcatgcaccgagatgtgaagccatccaacatc
cttgtcaactcccgaggggagatcaagttgtgcgactttggggtgagcgggcagctcatc
gattccatggccaactccttcgtgggaacacggtcctacatgtctccggagcggctgcag
ggcactcactactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccatcggaaggtaccccatccccccaccggatgccaaggagctggaggccatatttggc
cggcccatggttgatggaggggacggagagcctcacagcatctcgccacggccgagaccc
cctggacgccccatcagcggtcacgggatggacagccggccggccatggctatcttcgag
ctgctggactacatcgtgaatgagccacctcccaagctgcccaatggcgtcttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagcagagcgagcggatctg
aagatgctcatgaaccacaccttcatcaaacggtccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaacgctgcggctgaaccagcccagcacgcccacgcgcaccgccgtg
tga

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