KEGG   Trachypithecus francoisi (Francois's langur): 117066917
Entry
117066917         CDS       T07225                                 
Symbol
BRCA1
Name
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
tfn  Trachypithecus francoisi (Francois's langur)
Pathway
tfn01524  Platinum drug resistance
tfn03440  Homologous recombination
tfn03460  Fanconi anemia pathway
tfn04120  Ubiquitin mediated proteolysis
tfn04151  PI3K-Akt signaling pathway
tfn05206  MicroRNAs in cancer
tfn05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:tfn00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    117066917 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    117066917 (BRCA1)
   03460 Fanconi anemia pathway
    117066917 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    117066917 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    117066917 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    117066917 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    117066917 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:tfn01009]
    117066917 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:tfn04121]
    117066917 (BRCA1)
   03036 Chromosome and associated proteins [BR:tfn03036]
    117066917 (BRCA1)
   03400 DNA repair and recombination proteins [BR:tfn03400]
    117066917 (BRCA1)
Enzymes [BR:tfn01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     117066917 (BRCA1)
Protein phosphatases and associated proteins [BR:tfn01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     117066917 (BRCA1)
Ubiquitin system [BR:tfn04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    117066917 (BRCA1)
  Multi subunit Ring-finger type E3
   BRCC complex
    117066917 (BRCA1)
Chromosome and associated proteins [BR:tfn03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     117066917 (BRCA1)
DNA repair and recombination proteins [BR:tfn03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     117066917 (BRCA1)
    BRCA1-A complex
     117066917 (BRCA1)
    BRCA1-B complex
     117066917 (BRCA1)
    BRCA1-C complex
     117066917 (BRCA1)
    BRCA complex
     117066917 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     117066917 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-C3HC4_4 zf-RING_UBOX zf-C3HC4_3 zf-RING_2 zf-RING_5 zf-Nse BRCT_2 zf-RING_6 zf-RING_10 zf-ANAPC11 zf-rbx1 RTT107_BRCT_5 Prok-RING_4 zf-RING_4
Other DBs
NCBI-GeneID: 117066917
NCBI-ProteinID: XP_033038742
Position
Unknown
AA seq 1758 aa
MDLSAVRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCRFCMLKLLNQKKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLKIIHAFQLDTGLQFANSYNFAKKENNSPEHLKD
EVSLIQSMGYRNRAKRLLQSEPENPSLQETSLSVPLSNFGIVRTLRTKQRIQPQKKSVCI
ELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDETSLDSAKKAACEFSEKDITNTEHHQ
SSNNDLNTTEKHATERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVE
KAEFCNKSKQPGLARSQHNRWTGSKETCNDRQTPSTEKKVDLNADTLYERKERNKQKLPC
SENPRDTEDVPWITLNSSIQKVNEWFSRSDELLSSDDSHDGGSESNAKVADVLDVLNEVD
EYSGSSEKIDLLASDPHEALICKSERVHSSSVESNIEDKIFGKTYRRKAKLPDLSHVTEN
LIIGALVTESQIMQERPLTNKLKRKRRTTSGLHPEDFIKKADLAVQKTPEMINQGTNQME
QNGQVMNITNSVHENKTKGDSIQNEKNPDPIESLEEESAFKTKSEPISSSINNMELELNI
HSSKAPKKNRLRRKSSTRHIHALELVVSRNLRPPNCTELQIDSCSSSEEIKKKNYNQMPV
RHSRNLQLMEDKESATGAKKSNKPNEQTSKRHASDTFPELKLTKVPRSFTNCSNTSELKE
FVNPSLSREEKEEKLETVKVSNNAKDPKDLMLSGERVLQTEKSVESSSISLVPGTDYGTQ
ESISLLEVSTLGKAKTEQNKCVSQCAAFENPKELIHGCSEDTRNDTEGFKYPLGREVNHS
QETSIEIEESELDTQYLQNTFKVSKRQSFALFSNAGNPEEECATFSAHSKSLKKQSPKVT
SECEQKEENQGKKESNIKPVQTVNITAGFPVVCQKDKPVDNAKCSIKGGSMFCLSSQFRG
NETVLITPNKHGLLQNPYHIPPLFPVRSFVKTKCKKNLLEENSEEHSVSPERTVGNENII
PSTVSTISHNNIRENAFKEGSSSNINEVGSSTNEVGSSINEVGSSDENIQAELGRNRGPQ
LNAVLRLGLLQPEICKQSLPISNCKHPEIKKQEHEEVVQTVNTDFSPCLISDNLEQPMGS
SHVSEVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQRGELSRSPSPFTHTHLA
QGYQRGAKKLESSEENLSSEDEELPCFQHLLFGKVSNIPSQTTRHSTVATECLSKNTEEN
LLSLKNSLTDCSNQVILAKASQEHHLSEETKGSGSLFSSQCSELEDLTANTNTQDPFLIG
SSKRMRHQSESQGVGLSDKELVSDDEERGTGLEEDNPEEQSVDSNLGEAASGYESETSVS
EDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAELEAVLEQHGSQPSNSYRSIVTDSSAL
EDLRNPEQSTSEKEGTPYLESGISLFSDDPESDPSEDRALESAHVGSIPSSTSALKVPQW
QVAESAQSPAAAHNTNTAEYNAMEESVSREKPKLTASTERVNKRMSLVVSGLTPEEFMLV
YKFARRYHIALTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKE
RKMLNEHDFEVRGDVVNGRNHQGPKRARESPDRKIFRGLEICCYGPFTNMPTDQLEWMVQ
LCGASVVKELSSFTLGTGFHPVVVVQPDAWTEDNGFHAIGRMCEAPVVTREWVLDSVALY
QCQELDTYLIPQIPHNHY
NT seq 5277 nt   +upstreamnt  +downstreamnt
atggatttatctgctgttcgcgttgaagaagtacaaaatgtcattaatgctatgcagaaa
atcttagagtgtccaatctgtctggagttgatcaaggaacctgtctccacaaagtgtgac
cacatattttgcagattttgcatgctgaaacttctcaaccagaagaaagggccttcacag
tgtcctttgtgtaagaatgatataaccaaaagaagcctacaagaaagtacaagatttagt
caacttgttgaagagctattgaaaatcattcatgcttttcagcttgacacaggtttgcag
tttgcaaacagttataattttgcaaaaaaggaaaataactctcctgaacatctaaaggat
gaagtttctctcatccaaagtatgggctacagaaaccgtgccaaaagacttctacagagt
gaacccgaaaatccttccttgcaggaaaccagtctcagtgtcccactctctaactttgga
attgtgagaactctgaggacaaagcagcggatacaacctcaaaagaagtctgtctgcatt
gaactgggatctgattcttctgaagatacggttaataaagcaacttattgcagtgtggga
gatcaagaattgttacaaatcacccctcaaggaaccagggatgaaaccagtttggattct
gcaaaaaaggctgcttgtgaattttctgagaaggatataacaaatactgaacatcatcag
tccagtaataatgatttgaataccactgagaagcatgcaactgagaggcatccagaaaag
tatcagggtagttctgtttcaaacttgcatgtggagccatgtggcacaaatactcatgcc
agctcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaa
aaggctgaattctgtaataaaagcaaacagcctggcttagcaaggagccaacataataga
tggactggaagtaaggaaacatgtaatgataggcagactcccagcacagagaaaaaggta
gatctgaatgctgataccctgtatgagagaaaagaaaggaataagcagaaactgccatgc
tctgagaatcctagagacactgaagatgttccttggataacactaaatagcagcattcag
aaagttaatgagtggttttccagaagtgatgaactgttaagttctgatgactcacatgat
gggggttctgaatcaaatgccaaagtagctgatgtattggatgttcttaatgaggtagat
gaatattctggttcttcagagaaaatagacttactggccagtgatcctcatgaggcttta
atatgtaaaagtgaaagagttcactccagttcagtagagagtaacattgaagataaaata
tttgggaaaacctatcggaggaaggcaaagcttcccgatttaagccatgtaactgaaaat
ctaattataggagcacttgttactgagtcacagataatgcaagagcgtcccctcacaaat
aaattaaagcgtaaaaggagaactacatcaggtcttcatcctgaggattttataaagaaa
gcagatttggcagttcaaaagactcctgaaatgataaatcagggaactaaccaaatggag
cagaatggtcaagtgatgaatattactaatagtgttcatgagaataaaacaaaaggtgat
tctattcagaatgagaaaaatcctgacccaatagaatcactggaagaagaatctgctttc
aaaactaaatctgaacctataagcagcagtataaacaatatggaactagaattaaatatc
cacagttcaaaagcacctaaaaagaataggctgaggaggaagtcttctaccaggcatatt
catgcgcttgaactagtagtcagtagaaatctaaggccacctaattgtactgaactacaa
attgatagttgttctagcagtgaagagataaagaaaaaaaattacaaccaaatgccagtc
aggcacagcagaaacctacaactcatggaagataaagaatctgcaactggagccaagaag
agtaacaagccaaatgaacagacaagtaaaagacatgccagtgatactttcccagaactg
aagttaacaaaggtacctcgttcttttactaactgttcaaatactagtgaacttaaagaa
tttgtcaatcctagcctttcaagagaagaaaaagaagagaaactagaaacagttaaagta
tctaataatgccaaagaccccaaagatctcatgttaagtggagaaagggttttacaaact
gaaaaatctgtagagagtagcagtatttcattggtacctggtactgattatggcactcag
gaaagtatctcattactggaagttagcactctagggaaagcaaaaacagaacaaaataaa
tgtgtgagtcagtgtgcagcatttgaaaaccccaaggaactaattcatggttgttctgaa
gatactagaaatgacacagaaggctttaagtatccattgggacgtgaagttaaccacagt
caggaaacaagcatagaaatagaagaaagtgaacttgatactcagtatttgcagaataca
ttcaaggtttcaaagcgccagtcctttgctctgttttcaaatgcaggaaatccagaagag
gaatgtgcaacattctctgcccactctaagtccttaaagaaacaaagtccaaaagttact
tctgaatgtgaacaaaaggaagaaaatcaaggaaagaaagagtctaatatcaagcctgta
cagacagttaatatcactgcaggctttcctgtggtttgtcagaaagataagccagttgat
aatgccaaatgtagtatcaaaggaggctctatgttttgtctatcatctcagttcagaggc
aacgaaactgtactcattactccaaataaacatggacttttacaaaacccataccatata
ccaccactttttcctgtcaggtcatttgttaaaactaaatgtaagaaaaacctgctagag
gaaaactctgaggaacattcagtgtcacctgaaagaacagtgggaaatgagaacatcatt
ccaagtacagtgagcacaattagccataataacattagagaaaatgcttttaaagaaggc
agctcgagcaatattaatgaagtaggttccagtactaatgaagtgggctccagtattaat
gaagtaggttccagtgatgaaaacattcaggcagaactaggtagaaacagagggccacaa
ttgaatgctgtgcttagattagggcttttgcaacctgagatctgtaaacaaagtcttcct
ataagtaattgtaagcatcctgaaataaaaaagcaagaacatgaagaagtagttcagact
gttaatacagacttctctccatgtctgatttcagataacctagaacagcctatgggaagt
agtcatgtgtctgaggtttgttctgagactcctgatgacctgttagatgatggtgaaata
aaggaagatactagttttgctgaaaatgacattaaggagagttctgctgtttttagcaaa
agcgtccagagaggagagctcagcaggagccctagtcctttcacccatacacatttggct
cagggttaccaaagaggggccaagaaattagagtcctcggaagagaacttatctagtgag
gatgaagagcttccctgcttccaacacttgttatttggtaaagtaagcaatataccttct
cagactactaggcatagcactgttgctaccgagtgtctgtctaagaacacagaggagaat
ttattatcattgaagaatagcttaactgactgtagtaaccaggtaatattggcaaaggca
tcccaggaacatcaccttagtgaggaaacaaaaggttctggtagcttgttttcttcacag
tgcagtgaactggaagacttgactgcaaatacaaacacccaggatcctttcttgattggt
tcttccaaacgaatgaggcatcagtctgaaagccagggagttggtctgagtgacaaggaa
ttggtttcagatgatgaagaaaggggaacgggcttggaagaagataatccagaagagcaa
agtgtggattcaaacttaggtgaagcagcatccgggtatgagagtgaaacaagcgtctct
gaagactgctcaaggctctcctctcagagcgaaattttaaccactcagcagagggatacc
atgcaagataacctaataaagctccagcaggaaatggctgaactagaagctgtgttagaa
cagcatggaagccagccttctaacagctaccgttccatcgtaactgactcttctgccctt
gaggaccttcgaaatccagaacaaagcacatcagaaaaagagggaacaccttacctggaa
tctggaatcagtctcttctctgatgaccctgaatctgatccttctgaagacagagcccta
gagtcagctcatgttggcagcataccatcttcaacctctgcattgaaagtaccccagtgg
caagttgcagaatctgcccagagtccagctgctgctcataatactaatactgctgagtat
aatgcaatggaagaaagtgtgagcagggagaagccaaaattgacagcttcaacagaaagg
gtcaacaaaagaatgtccttggtggtgtctggcctgaccccagaagaatttatgctcgtg
tacaagtttgccagaagataccacatcgctttaactaatctaattactgaagagactact
catgttgttatgaaaacagatgctgagtttgtgtgtgaacggacgctgaaatattttctg
ggaattgcgggaggaaaatgggtagttagctatttctgggtgacccagtctattaaagaa
agaaaaatgctgaatgagcatgattttgaagtcagaggagatgtggtcaatggaagaaac
caccaaggtccaaagcgagcaagagaatccccggacagaaagatcttcagggggctagaa
atctgttgctatgggcccttcaccaacatgcccacagatcaactggaatggatggtacag
ctgtgtggtgcttctgtggtgaaggagctttcatcattcacccttggcacaggtttccac
ccagttgtggttgtgcagccagatgcctggacagaggacaatggcttccatgcaatcggg
cggatgtgtgaggcacctgtggtgacccgagagtgggtgttggacagtgtagcactctac
cagtgccaggagctggacacctacctgataccccagatcccccacaaccactactga

  All links  
Ontology (6)   
   KEGG BRITE (6)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (9)   
   RefSeq(pep) (9)   
DNA sequence (11)   
   RefSeq(nuc) (9)   
   GenBank (1)   
   EMBL (1)   
Protein domain (18)   
   Pfam (18)   
All databases (56)   

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