ID A0A031WDI8_CLODI Unreviewed; 348 AA.
AC A0A031WDI8;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Acetoin dehydrogenase E2 component (Dihydrolipoamide acetyltransferase) {ECO:0000313|EMBL:CDT02327.1};
DE EC=2.3.1.12 {ECO:0000313|EMBL:CDT02327.1};
GN Name=acoC {ECO:0000313|EMBL:CDT02327.1};
GN ORFNames=BN1095_240019 {ECO:0000313|EMBL:CDT02327.1}, BN1096_80018
GN {ECO:0000313|EMBL:CDS90297.1}, BN1097_70019
GN {ECO:0000313|EMBL:CDS88933.1};
OS Clostridioides difficile (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=1496 {ECO:0000313|EMBL:CDT02327.1};
RN [1] {ECO:0000313|EMBL:CDT02327.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7032989 {ECO:0000313|EMBL:CDT02327.1}, and 7032994
RC {ECO:0000313|EMBL:CDS88933.1};
RA Monot Marc;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
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DR EMBL; LK932409; CDS88933.1; -; Genomic_DNA.
DR EMBL; LK932535; CDS90297.1; -; Genomic_DNA.
DR EMBL; LK932894; CDT02327.1; -; Genomic_DNA.
DR RefSeq; WP_004453963.1; NZ_VINA01000018.1.
DR GeneID; 66352534; -.
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 2.
DR PROSITE; PS51826; PSBD; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CDT02327.1};
KW Transferase {ECO:0000313|EMBL:CDT02327.1}.
FT DOMAIN 7..44
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT DOMAIN 50..87
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 348 AA; 38215 MW; 85DAD1C898527A7E CRC64;
MVANKIKATP AARSQARKDN IKLDRLIGSG ENGRIHLVDV LNYLKDNKAN TTPLARRIAE
DLNIDLETIV GTGYNGKIRK CDVEKLTAKE TIVSTNTSKS SEKKELKIEN ENSSMFNTVE
GIFEKPNPMR ATVAKRMSES YFSAPVFTFN IEVDATELKV LRAKLIDTVK ESTGVKLTMT
DLIVMAVSKI LPNHQALNSA WTDEGIFRYK DVNIAIAVGL DEGLYVPVVK NANKKSLKEI
AKESKELAEK VKTGKLMPAD QEGNTFTISN VGMYGITTFT PIINMPSSAI LGVGATQDKF
VPVNGEAKIK PIMNLSLTSD HRVIDGTVAA KFLKDLKELL ENPLSMLV
//
