ID A0A076N2G8_AMYME Unreviewed; 341 AA.
AC A0A076N2G8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Alcohol dehydrogenase GroES domain-containing protein {ECO:0000313|EMBL:AIJ24097.1};
GN Name=adh {ECO:0000313|EMBL:AIJ24097.1};
GN ORFNames=AMETH_4005 {ECO:0000313|EMBL:AIJ24097.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ24097.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ24097.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ24097.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009110; AIJ24097.1; -; Genomic_DNA.
DR RefSeq; WP_026153189.1; NZ_CP009110.1.
DR AlphaFoldDB; A0A076N2G8; -.
DR STRING; 1068978.AMETH_4005; -.
DR KEGG; amq:AMETH_4005; -.
DR PATRIC; fig|1068978.7.peg.4293; -.
DR eggNOG; COG1064; Bacteria.
DR HOGENOM; CLU_026673_11_2_11; -.
DR OrthoDB; 334894at2; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd05284; arabinose_DH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43401:SF5; ALCOHOL DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000062973};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..339
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 341 AA; 35788 MW; 88EE272C2F8FDA9E CRC64;
MRAVQVVGYH ENLRMTEVPE PEVTGPWDVV VKIGGAGVCR TDIHILEGQW AEKSGVTLPY
TIGHENAGWV HAVGSAVTNV AEGDKVIVHP LITCGLCAAC RAGDDVHCVS SAFPGIDTHG
GYAEYLKTSA RSVVHIDDSL EPADVAALAD AGLTAYHAAA KAARRLRPGD RCVVIGAGGL
GHIGIQVLKA LTAAELIVVD RNPDAVKLAV SIGADHGVVA EGRQVEEVLD LTGGAGAEVV
LDFVGEGGAT RDGVGMLRRA GDYHVVGYGE NIDVPTIDII STEINFIGNL VGSYTDLCEL
MVLAAQGKVR LHTTKYPLER FQDAIDDLDA GRIRGRAILT P
//
