UniProt/TrEMBL: A0A0D6GJB8

Database: UniProt/TrEMBL
Entry: A0A0D6GJB8_STAAU

LinkDB:  A0A0D6GJB8_STAAU 
Original site:  A0A0D6GJB8_STAAU

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (6)   
   EMBL (6)   
Protein domain (9)   
   InterPro (6)   
   Pfam (1)   
   PROSITE (2)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   A0A0D6GJB8_STAAU        Unreviewed;       495 AA.
AC   A0A0D6GJB8; A0A1E8XBK4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Putative aldehyde dehydrogenase AldA {ECO:0000256|ARBA:ARBA00039869};
DE            EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN   Name=aldA {ECO:0000313|EMBL:AXP70046.1};
GN   ORFNames=DD547_00160 {ECO:0000313|EMBL:AXP70046.1}, EP54_05950
GN   {ECO:0000313|EMBL:KMR57375.1}, EQ90_11770
GN   {ECO:0000313|EMBL:KMR35590.1}, GO814_11610
GN   {ECO:0000313|EMBL:MVK35785.1}, GO942_10310
GN   {ECO:0000313|EMBL:MVM11085.1}, HMPREF3211_02701
GN   {ECO:0000313|EMBL:KXA32230.1};
OS   Staphylococcus aureus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:KXA32230.1, ECO:0000313|Proteomes:UP000070177};
RN   [1] {ECO:0000313|EMBL:KMR35590.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA15 {ECO:0000313|EMBL:KMR35590.1}, and M121
RC   {ECO:0000313|EMBL:KMR57375.1};
RX   PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA   Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G.,
RA   Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J.,
RA   Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M.,
RA   Robinson D.A., Arias C.A.;
RT   "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus USA300 Infection in North and South America.";
RL   J. Infect. Dis. 212:1874-1882(2015).
RN   [2] {ECO:0000313|EMBL:KXA32230.1, ECO:0000313|Proteomes:UP000070177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PSS7673 {ECO:0000313|EMBL:KXA32230.1,
RC   ECO:0000313|Proteomes:UP000070177};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AXP70046.1, ECO:0000313|Proteomes:UP000259766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=64 {ECO:0000313|EMBL:AXP70046.1,
RC   ECO:0000313|Proteomes:UP000259766};
RA   Chako K., Divya B., Pak T., Sause W., Kumar K., Sebra R., Deikus G.,
RA   Attie O., Rose H., Lewis M., Li Y., Bashir A., Kasarskis A., Schadt E.,
RA   Richardson A.R., Torres V., Shopsin B.;
RT   "Colonizing and infecting subclones diverge during Staphylococcus aureus
RT   infection.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AXP70046.1, ECO:0000313|Proteomes:UP000259766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=64 {ECO:0000313|EMBL:AXP70046.1,
RC   ECO:0000313|Proteomes:UP000259766};
RA   Chako K.I., Sullivan M.J., van Bakel H.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000471199, ECO:0000313|Proteomes:UP000478867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM11085.1,
RC   ECO:0000313|Proteomes:UP000478867}, and S_2062.LAUP.DI
RC   {ECO:0000313|EMBL:MVK35785.1, ECO:0000313|Proteomes:UP000471199};
RA   Stine O.C.;
RT   "Implementation of targeted gown and glove precautions to prevent
RT   Staphylococcus aureus acquisition in community-based nursing homes.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP031670; AXP70046.1; -; Genomic_DNA.
DR   EMBL; LALJ01000031; KMR35590.1; -; Genomic_DNA.
DR   EMBL; LALQ01000021; KMR57375.1; -; Genomic_DNA.
DR   EMBL; LRQH01000202; KXA32230.1; -; Genomic_DNA.
DR   EMBL; WPTS01000035; MVK35785.1; -; Genomic_DNA.
DR   EMBL; WPXC01000017; MVM11085.1; -; Genomic_DNA.
DR   RefSeq; WP_000290400.1; NZ_WOFG01000001.1.
DR   PATRIC; fig|1280.3350.peg.150; -.
DR   OMA; PMPIAAW; -.
DR   Proteomes; UP000070177; Unassembled WGS sequence.
DR   Proteomes; UP000259766; Chromosome.
DR   Proteomes; UP000471199; Unassembled WGS sequence.
DR   Proteomes; UP000478867; Unassembled WGS sequence.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   CDD; cd07117; ALDH_StaphAldA1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          21..483
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        256
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   495 AA;  53659 MW;  DCBE4F433645A52A CRC64;
     MAVNVRDYIA ENYGLFINGE FVKGSSDETI EVTNPATGET LSHITRAKDK DVDHAVKVAQ
     EAFESWSLTS KSERAQMLRD IGDKLMAQKD KIAMIETLNN GKPIRETTAI DIPFAARHFH
     YFASVIETEE GTVNDIDKDT MSIVRHEPIG VVGAVVAWNF PMLLAAWKIA PAIAAGNTIV
     IQPSSSTPLS LLEVAKIFQE VLPKGVVNIL TGKGSESGNA IFNHDGVDKL SFTGSTDVGY
     QVAEAAAKHL VPATLELGGK SANIILDDAN LDLAVEGIQL GILFNQGEVC SAGSRLLVHE
     KIYDQLVPRL QEAFSNIKVG NPQDEATQMG SQTGKDQLDK IQSYIDAAKE SDAQILAGGH
     RLTENGLDKG FFFEPTLIAV PDNHHKLAQE EIFGPVLTVI KVKDDQEAID IANDSEYGLA
     GGVFSQNITR ALNIAKAVRT GRIWINTYNQ VPEGAPFGGY KKSGIGRETY KGALSNYQQV
     KNIYIDTSNA LKGLY
//

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