ID A0A0H2WXE4_STAAC Unreviewed; 1243 AA.
AC A0A0H2WXE4;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Cell wall surface anchor family protein {ECO:0000313|EMBL:AAW37284.1};
GN Name=sasG {ECO:0000313|EMBL:AAW37284.1};
GN OrderedLocusNames=SACOL2505 {ECO:0000313|EMBL:AAW37284.1};
OS Staphylococcus aureus (strain COL).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93062 {ECO:0000313|EMBL:AAW37284.1, ECO:0000313|Proteomes:UP000000530};
RN [1] {ECO:0000313|EMBL:AAW37284.1, ECO:0000313|Proteomes:UP000000530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL {ECO:0000313|EMBL:AAW37284.1,
RC ECO:0000313|Proteomes:UP000000530};
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J., Khouri H., Utterback T., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
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DR EMBL; CP000046; AAW37284.1; -; Genomic_DNA.
DR RefSeq; WP_001205093.1; NC_002951.2.
DR AlphaFoldDB; A0A0H2WXE4; -.
DR SMR; A0A0H2WXE4; -.
DR KEGG; sac:SACOL2505; -.
DR HOGENOM; CLU_000977_1_0_9; -.
DR Proteomes; UP000000530; Chromosome.
DR Gene3D; 2.20.230.30; -; 3.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.20.230.10; Resuscitation-promoting factor rpfb; 1.
DR InterPro; IPR011098; G5_dom.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR031477; SasG_E.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR01168; YSIRK_signal; 1.
DR PANTHER; PTHR37824; IRON-REGULATED SURFACE DETERMINANT PROTEIN C; 1.
DR PANTHER; PTHR37824:SF1; IRON-REGULATED SURFACE DETERMINANT PROTEIN C; 1.
DR Pfam; PF18483; Bact_lectin; 1.
DR Pfam; PF07501; G5; 6.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17041; SasG_E; 5.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SMART; SM01208; G5; 6.
DR PROSITE; PS51109; G5; 6.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 419..501
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 547..629
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 675..757
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 803..885
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 931..1013
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 1059..1141
FT /note="G5"
FT /evidence="ECO:0000259|PROSITE:PS51109"
FT DOMAIN 1211..1243
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 74..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 136345 MW; 77610477B2623BB6 CRC64;
MRDKKGPVNK RVDFLSNKLN KYSIRKFTVG TASILIGSLM YLGTQQEAEA AENNIENPTT
LKDNVQSKEV KIEEVTNKDT APQGVEAKSE VTSNKDTIEH EPSVKAEDIS KKEDTPKEVA
DVAEVQPKSS VTHNAETPKV RKARSVDEGS FDITRDSKNV VESTPITIQG KEHFEGYGSV
DIQKKPTDLG VSEVTRFNVG NESNGLIGAL QLKNKIDFSK DFNFKVRVAN NHQSNTTGAD
GWGFLFSKGN AEEYLTNGGI LGDKGLVNSG GFKIDTGYIY TSSMDKTEKQ AGQGYRGYGA
FVKNDSSGNS QMVGENIDKS KTNFLNYADN STNTSDGKFH GQRLNDVILT YVASTGKMRA
EYAGKTWETS ITDLGLSKNQ AYNFLITSSQ RWGLNQGINA NGWMRTDLKG SEFTFTPEAP
KTITELEKKV EEIPFKKERK FNPDLAPGTE KVTREGQKGE KTITTPTLKN PLTGVIISKG
EPKEEITKDP INELTEYGPE TIAPGHRDEF DPKLPTGEKE EVPGKPGIKN PETGDVVRPP
VDSVTKYGPV KGDSIVEKEE IPFEKERKFN PDLAPGTEKV TREGQKGEKT ITTPTLKNPL
TGVIISKGEP KEEITKDPIN ELTEYGPETI TPGHRDEFDP KLPTGEKEEV PGKPGIKNPE
TGDVVRPPVD SVTKYGPVKG DSIVEKEEIP FKKERKFNPD LAPGTEKVTR EGQKGEKTIT
TPTLKNPLTG EIISKGESKE EITKDPINEL TEYGPETITP GHRDEFDPKL PTGEKEEVPG
KPGIKNPETG DVVRPPVDSV TKYGPVKGDS IVEKEEIPFK KERKFNPDLA PGTEKVTREG
QKGEKTITTP TLKNPLTGEI ISKGESKEEI TKDPINELTE YGPETITPGH RDEFDPKLPT
GEKEEVPGKP GIKNPETGDV VRPPVDSVTK YGPVKGDSIV EKEEIPFEKE RKFNPDLAPG
TEKVTREGQK GEKTITTPTL KNPLTGEIIS KGESKEEITK DPVNELTEFG GEKIPQGHKD
IFDPNLPTDQ TEKVPGKPGI KNPDTGKVIE EPVDDVIKHG PKTGTPETKT VEIPFETKRE
FNPKLQPGEE RVKQEGQPGS KTITTPITVN PLTGEKVGEG QPTEEITKQP VDKIVEFGGE
KPKDPKGPEN PEKPSRPTHP SGPVNPNNPG LSKDRAKPNG PVHSMDKNDK VKKSKIAKES
VANQEKKRAE LPKTGLESTQ KGLIFSSIIG IAGLMLLARR RKN
//
