ID A0A0K1JTS1_9BURK Unreviewed; 4306 AA.
AC A0A0K1JTS1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AKU20507.1};
GN ORFNames=ACZ75_02210 {ECO:0000313|EMBL:AKU20507.1};
OS Massilia sp. NR 4-1.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1678028 {ECO:0000313|EMBL:AKU20507.1, ECO:0000313|Proteomes:UP000056897};
RN [1] {ECO:0000313|EMBL:AKU20507.1, ECO:0000313|Proteomes:UP000056897}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NR 4-1 {ECO:0000313|EMBL:AKU20507.1,
RC ECO:0000313|Proteomes:UP000056897};
RA Sul W.J.;
RT "Massilia sp. NR 4-1 isolated from rhizosphere of Torreya nucifera in
RT national heritage Bijarim forest, volcanic Jeju Island, Korea.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; CP012201; AKU20507.1; -; Genomic_DNA.
DR RefSeq; WP_050407227.1; NZ_CP012201.1.
DR STRING; 1678028.ACZ75_02210; -.
DR KEGG; mnr:ACZ75_02210; -.
DR PATRIC; fig|1678028.3.peg.437; -.
DR OrthoDB; 6297021at2; -.
DR Proteomes; UP000056897; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd19535; Cyc_NRPS; 2.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000056897};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 656..731
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 796..1215
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2175..2252
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3638..3713
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4195..4270
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 597..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3620..3640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4272..4306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4306 AA; 461619 MW; 70C44379A4988266 CRC64;
MTAFPAISLS QHPTLVDWIE YHARTQPEAE ALCFVAHQGE GQAELRLSYG ALSQRVRQAA
AALQRCSRPG DSALILFPSG IDYVVALLAC FYAGVTGVPV NLPGAARVRR VLPKLGGIAA
DCRPALVLSS AAIAAASGDA LQAFATEHRL ELLQLDRLQA DAGAWQRPAL DGATLAFLQY
TSGSTGQPKG VVNRHGALLR NLEFLGRLTA VDRRARSATV VASWLPLFHD LGLIMGILLP
LAYGSRAVYM APMAFAADPL RWLEVASAEQ ATALPCPSFA LRLCAEEAAA APQRLAQIAL
ERVGCLMPAA EPVLPEQIER FHAVFGARGL RRTAIKPAYG LAEATLLVSA HVADREPYYI
DVDKTLLERG RAVAQPASGA LPPPGMRRYT SNGNEFDGQE VRIVDADKHV PLSADTVGEI
WISGRCVADG YWNKEELNRA LFLARAAGSE AAYLRTGDMG FVHEGHLFVT GRLKDMLLFR
GECHYPNDIE NSGGRAHAAC VPESGAAFSL PAEDESTELL VVVQEVAKQS SNDYTAIADA
VRVAVAEEHQ LAAHAVVLIR KGTLPRTTSG KVRRSAVRAA WLAGELAVLH EQRLDGPDAV
PAPAAQSTPA GQDAGRDSAM AGANTATPAG GDAHGAAPDG ALLAALRPLG AAQRGEHLCG
WLAQQTAAIL GTVAARAIRP EASLFGYGMD SMSAARLGAA AAKACALPVP DKLLFDQPTL
LQLSAWLLDG MAAAGVLPAA AATPAMAAGS AAREGAALAA NGAAAVSGSA AAYGAATAHG
TAATDGTAGQ PGPHSPEAIA IIGMAYRLPG ANGQDADSDA AFWSMLESGG CAIRPAPSER
FRTRDDIPGF GAYLNHVDRF DAAFFGMSPR EAMNTDPQQR LLLEVGWHAL EDAGLAPSRL
RGSDTGVFVG IGTGDYGHIP FISGTPAHFD AYWGTGTSFA AACGRLSFSF GWEGPSMAID
TACSASHSAL HLAVQSLRAR ESGLALAAGV KLQLLPEVDL VLHKAGMLAA DGRCKTLDAR
ADGYVRGEGC VVLVLKRLNE ALADGDPVRA VIRDSLVRQD GAGSSLSAPN GAAQQRLLEL
SLRRAGLRPA DIDYVELHGT GTRLGDPIEY QSVADVFRGR AAEDPLWLGS VKTNIGHLES
AAGAAGLAKT ILALEHGRLP PAVGLREVNP LIDLDAIPAR VPTACVDWPA RQALRRAGVT
SYGFAGTIAH VLLEQAPPAL PAAKAAPGTT LPLYLLSARS AESLRMLAAA YRQSLDSQAD
LAALARGMAR QRDHHPLRAA ISAASRAELG EALQRLAAGA QEAVETSGAP RIGFVFTGQG
SQYSGMARGL YACQPGFRAA LDAADAALAP HLGASIIALM HDEAQAPRLQ QTAIAQPALF
AVGYALAAMW QAWGLRPAVV LGHSIGEFAA MVVAGALTLE QAARLIVRRG ALMQALPAGG
AMLAARATPQ QAEAALAALP PALASQAALA ALNGPQDVVL SGSAAAIEAL RATLEAQDCH
ARPLTVSHAF HSPLLDPMLD AWEEACHGLA AQTPALPLCS TLSGEVLQQA PDAAYWRRHA
RQPVRFADAL QLAAGRCDVL LEIGAHAVLS AVAQRNQLAQ QWPQAVACVA SLRRGGDDLQ
AVADAAAALY QAGQDFDWQH MYAGTLPPPR SLPRYPFERH SYWLEYDEDA ARHPLQLQPQ
PERAAARPVD LYAVEWEAFA LPDAATAGRC WLLGGAAVEA EHFGAALQAQ GWSVQRASAV
EWPALAATLE DGDVVVYLDG WRARIEQLEG ARPAAGSAAG WPLTEFVKVL QSCRKTPRIL
LPTAGAHGMQ SGGGDPVQAA LWGAARALAL EYPGPRWLMA DSDAGLTPLA SALAALLPLF
GAEEGVALHQ QQWHRPRLAA VSEPQAFTAR ASSEGMYLVA GAYGALGRHA SDWLAARGAR
HLVLLARRTA PAGWQARLAL LRDQGIRIDH IDADVADRTS MEQAFQRIAA LEQDSGHRLL
GVFHCAGSSR FNDLAGITAE DYDAVSRSKV DGAWLLHEHT RNRALNWFVC FTSISGIWGS
RLQIPYGAAN AFQDALIRLR RAQGLPGLAA AWGPWGGGAG MSEVDEELLQ LLRAAGIRRL
APARYLATLD LLLGESAAPA LRCCVAAEVD WRQFVPLYGL YNPANTFERC LAASQASDAG
ARADTSALQG LDGDARAATV RNFVVAELAR TLRVPPAQLT PGIELLKLGM DSILVMDFAR
RCETGLGVKC ELKTIFQCNT PQRLADYLLE QLAQQTTPSA PAVAEHITAD PAGAHLPFPL
TELQHAYWIG RQSHYGLGGV ACHAYLEADA AQGLDLELLE RCWNVLVQRH GALRLVIGED
GRQRVLPEVP SYRLRVAQLE TAAPQEVERH CAEWRSAMSH QVMDASQWPL FDVRASRLQG
GAVRLHIGID MLINDATSGQ IIWQELADLY QAGGDQQAAG LQPFAISFRD YVLAKYEHSA
QRRAERAAAR EFWLQRIPTL PPAPQLPLRA EALRQNSPAF SRRQQRLDAA QWQSLRDQAM
QAGCTPASLL IAVFAEVLAA WSGEPRFTLN LTIFDRLPWH ADVPRLLGDF TAVTLLPLDC
ADALPFGQRA AAVNGAVLEH LQHRAFSAVD VMREWNRGRE RQDAIAMPVV FTSQLGMNDP
TKGAAPDSPL GVVGYGISQT PQVWLDHQAC ELDGALIYNW DAVDTLFQPG VLDAMFEAYH
ALLLRLAQQP QAWQQPVPAL LPPSQQEVRR QVNASAGPLP ERCLDQLFFD QAERTPGACA
LIAQEQQWSY GQLAAWSRRL ANALLAQQVR GGERIAVVMR KGPEQVAACL GILAAGAVYV
PVDADVPAAR LHAILEGSRI RLILSQPDCL PIVQEMCAGR AVQVLDAAQE AAAAWPDRAP
QPGARSLADH AYVIYTSGST GTPKGVTIDH RGAANTVLDI NRRFSVGAQD RVLGLSSLYF
DLSVYDMFGI FATGAALVLP LAAGTRDPGH WLSLVRRHGV TVWNTVPALL ELLLEEAEAS
GAALDGLCHV FLSGDWIPLP LPARLRKAAP KARLIAMGGA TEASIWSNWF AVPDSLPPHW
RSIPYGYPLA NQHYRVLDGQ LRDCPDHVTG DLYIGGIGLA LGYENDAEKT GASFITHPVH
GERLYRTGDL ARYWSDATLE FLGRRDFQVK IAGNRIELGE IESALLAHPG VREAVADAIG
PAQGQRRLAA WVIPQAGDDS LFDVLEGDAA QHARHWNAIG DSVQTLIQRQ DAASGALEEF
WRLMDHMGQC MMRDTLQEAG IGAGLAQAQD GAGRETVLQQ LAPGAELAAL ARRWLAVLPS
LPGYDSNAAW EELSPAALKF GLPRGVLQRL RAGAGQRLAV LRGQASALEL FYGADDTLAP
EQMTRLNPLS TLCTRALAAA IRRHAQQLGR APRILEVGGR SGAAARELLQ LLPDCALDYT
LCDPARTLIE QAEQAFAAQP KEKLHELRCR VFEHERPAPQ QGLAEGDYDL VLASNALHRS
ASVPALLQRL RALLAPGGLL LAPEITRNSD FQLATVALLE GGYSRLADRR QASGDALLGS
AAWQEELQAA GFAAAAAFGP GEQAGMHLLA ARQADRTLRF APRRLVEHLA ALLSAYMVPQ
TIMALDAMPL SPTGKVMRQQ LPRPEQGGER RARRQSGTAA PPVAQDLLQI WQELLGIGDL
HADDSFFDLG GDSLIAVRLI ERVRHGLNAH VSLSDLFDAP RLGDFAERVA RAAPYEDKLP
PLLPAPEQRH TPFPMTDVQQ AYWIGRDESF ELGGVSTHLY AEIEVDQLSH AALEQAWRRV
IGRHDMLRAV IDADGMQRVL PEVPPYSIVC HDLRGAGDAA VAECLELVRM ELSHEVFDTT
SWPLFTVRAA RMSEDTLRLF VSLDNLVCDG RSMRTLLAEW SLLARQPQTE LKPLTASFRD
YVMLSQQIEL LPSYQRSLAY WHGKLATLPP APALPLADYS REEVSPPHFS RREAVLEREQ
LAALQQQAAA HGVTLNAVLL AAYGAVLANW SAVPRFTLNL TLFNRPPVHE EIDALVGDFT
SLVLLEFNGA DGGFSNLALS MQRQIWADLE HMQVSAVRVL REAARRNRRL QQVAMPVVFT
SGLGVAGDGD GGMDWLGRFV YGISQTPQVW IDQQVVERDG ALVFNWDSVD ALFPPGLLDQ
MFAAYHALLQ RLAAQADSWT QPPSGAMPPN RWPARQRGTR AASATGTVAG DAAPVIEDSL
LHAVRSRLGA LLGQETPALQ QNFFELGASS LDLIRLRQQL QADTGLALGV TDVFQHTSIA
ALAAHLRSLQ RPAEADDSSA LNASQTRRRQ RQNNERRMKR SQQSGS
//
